O. Abe, Temporal changes of the apparent diffusion coefficients of water and metabolites in rats with hemispheric infarction: experimental study of transhemispheric diaschisis in the contralateral hemisphere at 7 tesla, J. Cereb. Blood Flow. Metab, vol.20, issue.4, pp.726-735, 2000.

V. Adalid, Fitting interrelated datasets: metabolite diffusion and general lineshapes, MAGMA, vol.1, issue.20, 2017.
DOI : 10.1007/s10334-017-0618-z

S. Allison, C. Y. Chen, and D. Stigter, The length dependence of translational diffusion, free solution electrophoretic mobility, and electrophoretic tether force of rigid rodlike model duplex DNA, Biophys. J, vol.81, issue.5, pp.2558-2568, 2001.

Y. Assaf and P. J. Basser, Composite hindered and restricted model of diffusion (CHARMED) MR imaging of the human brain, Neuroimage, vol.27, issue.1, pp.48-58, 2005.

Y. Assaf and Y. Cohen, In vivo and in vitro bi-exponential diffusion of N-acetyl aspartate (NAA) in rat brain: a potential structural probe?, Nmr Biomed, vol.11, issue.2, pp.67-74, 1998.

Y. Assaf and Y. Cohen, Non-mono-exponential attenuation of water and N-acetyl aspartate signals due to diffusion in brain tissue, J. Magn. Reson, vol.131, issue.1, pp.69-85, 1998.

Y. Assaf and Y. Cohen, Structural information in neuronal tissue as revealed by qspace diffusion NMR spectroscopy of metabolites in bovine optic nerve, Nmr Biomed, vol.12, issue.6, pp.335-344, 1999.

L. Avram, Y. Assaf, and Y. Cohen, The effect of rotational angle and experimental parameters on the diffraction patterns and micro-structural information obtained from q-space diffusion NMR: implication for diffusion in white matter fibers, J. Magn. Reson, vol.169, issue.1, pp.30-38, 2004.

B. Balinov, B. Jonsson, P. Linse, and O. S?-oderman, The NMR self-diffusion method applied to restricted diffusion. Simulation of echo attenuation from molecules in spheres and between planes, J. Magn. Reson Ser. A, vol.104, pp.17-25, 1993.

C. Ballatore, V. M. Lee, and J. Q. Trojanowski, Tau-mediated neurodegeneration in Alzheimer's disease and related disorders, Nat. Rev. Neurosci, vol.8, issue.9, pp.663-672, 2007.

A. Bar-shir, L. Avram, E. Ozarslan, P. J. Basser, and Y. Cohen, The effect of the diffusion time and pulse gradient duration ratio on the diffraction pattern and the structural information estimated from q-space diffusion MR: experiments and simulations, J. Magn. Reson, vol.194, issue.2, pp.230-236, 2008.

P. J. Basser, Inferring microstructural features and the physiological state of tissues from diffusion-weighted images, Nmr Biomed, vol.8, issue.7-8, pp.333-344, 1995.

P. J. Basser and D. K. Jones, Diffusion-tensor MRI: theory, experimental design and data analysis -a technical review, Nmr Biomed, vol.15, issue.7-8, pp.456-467, 2002.

E. Beard and O. Braissant, Synthesis and transport of creatine in the CNS: importance for cerebral functions, J. Neurochem, vol.115, issue.2, pp.297-313, 2010.

K. L. Behar and T. Ogino, Characterization of macromolecule resonances in the 1H NMR spectrum of rat brain, Magn. Reson Med, vol.30, issue.1, pp.38-44, 1993.

K. L. Behar, D. L. Rothman, D. D. Spencer, and O. A. Petroff, Analysis of macromolecule resonances in 1H NMR spectra of human brain, Magn. Reson Med, vol.32, issue.3, pp.294-302, 1994.

T. E. Behrens, Characterization and propagation of uncertainty in diffusionweighted MR imaging, Magn. Reson Med, vol.50, issue.5, pp.1077-1088, 2003.

L. Belle and J. E. , A comparison of cell and tissue extraction techniques using high-resolution 1H-NMR spectroscopy, NMR Biomed, vol.15, issue.1, pp.37-44, 2002.

Y. A. Bhagat and C. Beaulieu, Diffusion anisotropy in subcortical white matter and cortical gray matter: changes with aging and the role of CSF-suppression, J. Magn. Reson Imaging, vol.20, issue.2, pp.216-227, 2004.

L. Bihan and D. , Diffusion tensor imaging: concepts and applications, J. Magn. Reson Imaging, vol.13, issue.4, pp.534-546, 2001.
URL : https://hal.archives-ouvertes.fr/hal-00349820

Y. Bito, S. Hirata, T. Nabeshima, and E. Yamamoto, Echo-planar diffusion spectroscopic imaging, Magn. Reson Med, vol.33, issue.1, pp.69-73, 1995.
DOI : 10.1002/mrm.1910330110

Y. Bito, Diffusion-weighted line-scan echo-planar spectroscopic imaging technique to reduce motion artifacts in metabolite diffusion imaging, Magn. Reson Med. Sci, vol.14, issue.1, pp.43-50, 2015.

B. Bodini, Dysregulation of energy metabolism in multiple sclerosis measured in vivo with diffusion-weighted spectroscopy, Mult. Scler, p.1352458517698249, 2017.

V. O. Boer, D. W. Klomp, J. Laterra, and P. B. Barker, Parallel reconstruction in accelerated multivoxel MR spectroscopy, Magn. Reson Med, vol.74, issue.3, pp.599-606, 2015.
DOI : 10.1002/mrm.25718
URL : http://europepmc.org/articles/pmc4545732?pdf=render

D. Bonekamp, M. A. Smith, H. Zhu, and P. B. Barker, Quantitative SENSE-MRSI of the human brain, Magn. Reson Imaging, vol.28, issue.3, pp.305-313, 2010.

P. A. Bottomley, Spatial localization in NMR spectroscopy in vivo, Ann. N. Y. Acad. Sci, vol.508, pp.333-348, 1987.

A. Brand, C. Richter-landsberg, and D. Leibfritz, Multinuclear NMR studies on the energy metabolism of glial and neuronal cells, Dev. Neurosci, vol.15, issue.3-5, pp.289-298, 1993.

F. Branzoli, A. Techawiboonwong, H. Kan, A. Webb, and I. Ronen, Functional diffusion-weighted magnetic resonance spectroscopy of the human primary visual cortex at 7 T, Magn. Reson Med, vol.69, issue.2, pp.303-309, 2013.

F. Branzoli, E. Ercan, A. Webb, and I. Ronen, The interaction between apparent diffusion coefficients and transverse relaxation rates of human brain metabolites and water studied by diffusion-weighted spectroscopy at 7 T, Nmr Biomed, vol.27, issue.5, pp.495-506, 2014.

F. Branzoli, Differentiating between axonal damage and demyelination in healthy aging by combining diffusion-tensor imaging and diffusion-weighted spectroscopy in the human corpus callosum at 7 T, Neurobiol. Aging, vol.47, pp.210-217, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01376793

M. D. Budde and J. A. Frank, Neurite beading is sufficient to decrease the apparent diffusion coefficient after ischemic stroke, Proc. Natl. Acad. Sci. U. S. A, vol.107, issue.32, pp.14472-14477, 2010.

P. T. Callaghan, Principles of Nuclear Magnetic Resonance Microscopy, 1991.

P. T. Callaghan, Pulsed-gradient spin-echo Nmr for planar, cylindrical, and spherical pores under conditions of wall relaxation, J. Magn. Reson Ser. A, vol.113, issue.1, pp.53-59, 1995.

P. T. Callaghan, A. Coy, D. Macgowan, K. J. Packer, and F. O. Zelaya, Diffraction-like effects in Nmr diffusion studies of fluids in porous solids, Nature, vol.351, issue.6326, pp.467-469, 1991.

P. Cao and E. X. Wu, Accelerating phase-encoded proton MR spectroscopic imaging by compressed sensing, J. Magn. Reson Imaging, vol.41, issue.2, pp.487-495, 2015.
DOI : 10.1002/jmri.24553

P. Cao and E. X. Wu, In vivo diffusion MRS investigation of non-water molecules in biological tissues, Nmr Biomed, vol.30, issue.3, 2017.

P. Cao, Accelerated high-bandwidth MR spectroscopic imaging using compressed sensing, Magn. Reson Med, vol.76, issue.2, pp.369-379, 2016.
DOI : 10.1002/mrm.26272
URL : http://europepmc.org/articles/pmc4945498?pdf=render

S. Cerdan, B. Kunnecke, and J. Seelig, Cerebral metabolism of [1,2-13C2]acetate as detected by in vivo and in vitro 13C NMR, J. Biol. Chem, vol.265, issue.22, pp.12916-12926, 1990.

L. C. Chang, C. G. Koay, C. Pierpaoli, and P. J. Basser, Variance of estimated DTIderived parameters via first-order perturbation methods, Magn. Reson Med, vol.57, issue.1, pp.141-149, 2007.

J. K. Choi, A. Dedeoglu, and B. G. Jenkins, Application of MRS to mouse models of neurodegenerative illness, Nmr Biomed, vol.20, issue.3, pp.216-237, 2007.

A. Chvatal, M. Anderova, and F. Kirchhoff, Three-dimensional confocal morphometry -a new approach for studying dynamic changes in cell morphology in brain slices, J. Anat, vol.210, issue.6, pp.671-683, 2007.

Y. Cohen and Y. Assaf, High b-value q-space analyzed diffusion-weighted MRS and MRI in neuronal tissues -a technical review, Nmr Biomed, vol.15, issue.7-8, pp.516-542, 2002.

D. G. Cory, A. N. Garroway, and J. B. Miller, Applications of spin transport as a probe of local geometry, Abstr. Pap. Am. Chem. S, vol.199, p.105, 1990.

A. Delacourte and L. Buee, Tau pathology: a marker of neurodegenerative disorders, Curr. Opin. Neurol, vol.13, issue.4, pp.371-376, 2000.

R. M. Dijkhuizen, R. A. De-graaf, K. A. Tulleken, and K. Nicolay, Changes in the diffusion of water and intracellular metabolites after excitotoxic injury and global ischemia in neonatal rat brain, J. Cereb. Blood Flow. Metab, vol.19, issue.3, pp.341-349, 1999.

W. Dreher, E. Busch, and D. Leibfritz, Changes in apparent diffusion coefficients of metabolites in rat brain after middle cerebral artery occlusion measured by proton magnetic resonance spectroscopy, Magn. Reson Med, vol.45, issue.3, pp.383-389, 2001.

I. Drobnjak, H. Zhang, M. G. Hall, and D. C. Alexander, The matrix formalism for generalised gradients with time-varying orientation in diffusion NMR, J. Magn. Reson, vol.210, issue.1, pp.151-157, 2011.

F. Du, Myelin and axon abnormalities in schizophrenia measured with magnetic resonance imaging techniques, Biol. Psychiatry, vol.74, issue.6, pp.451-457, 2013.

J. M. Duarte, H. Lei, V. Mlynarik, and R. Gruetter, The neurochemical profile quantified by in vivo 1H NMR spectroscopy, Neuroimage, vol.61, issue.2, pp.342-362, 2012.

J. Ellegood, C. C. Hanstock, and C. Beaulieu, Trace apparent diffusion coefficients of metabolites in human brain using diffusion weighted magnetic resonance spectroscopy, Magn. Reson Med, vol.53, issue.5, pp.1025-1032, 2005.

J. Ellegood, C. C. Hanstock, and C. Beaulieu, Diffusion tensor spectroscopy (DTS) of human brain, Magn. Reson Med, vol.55, issue.1, pp.1-8, 2006.

J. Ellegood, R. T. Mckay, C. C. Hanstock, and C. Beaulieu, Anisotropic diffusion of metabolites in peripheral nerve using diffusion weighted magnetic resonance spectroscopy at ultra-high field, J. Magn. Reson, vol.184, issue.1, pp.20-28, 2007.

J. Ellegood, C. C. Hanstock, and C. Beaulieu, Considerations for measuring the fractional anisotropy of metabolites with diffusion tensor spectroscopy, Nmr Biomed, vol.24, issue.3, pp.270-280, 2011.

A. E. Ercan, A. Techawiboonwong, M. J. Versluis, A. G. Webb, and I. Ronen, Diffusionweighted chemical shift imaging of human brain metabolites at 7T, Magn. Reson Med, vol.73, issue.6, pp.2053-2061, 2015.

E. Ercan, Glial and axonal changes in systemic lupus erythematosus measured with diffusion of intracellular metabolites, Brain, vol.139, pp.1447-1457, 2016.

D. A. Feinberg and K. Setsompop, Ultra-fast MRI of the human brain with simultaneous multi-slice imaging, J. Magn. Reson, vol.229, pp.90-100, 2013.

J. Finsterbusch, Multiple-Wave-Vector diffusion-weighted NMR, Annu. Rep. Nmr Spectro, vol.72, pp.225-299, 2010.
DOI : 10.1016/b978-0-12-385857-3.00006-2

K. Fotso, Diffusion tensor spectroscopic imaging of the human brain in children and adults, Magn. Reson Med, vol.78, issue.4, pp.1246-1256, 2017.

J. Frahm, K. D. Merboldt, and W. Hanicke, Localized proton spectroscopy using stimulated echoes, J. Magn. Reson, vol.72, pp.502-508, 1987.
DOI : 10.1016/0022-2364(87)90154-5

M. Garwood and L. Delabarre, The return of the frequency sweep: designing adiabatic pulses for contemporary NMR, J. Magn. Reson, vol.153, issue.2, pp.155-177, 2001.

S. S. Gill, Brain metabolites as 1H NMR markers of neuronal and glial disorders, Nmr Biomed, vol.2, issue.5-6, pp.196-200, 1989.

R. A. De-graaf, K. P. Braun, and K. Nicolay, Single-shot diffusion trace (1)H NMR spectroscopy, Magn. Reson Med, vol.45, issue.5, pp.741-748, 2001.

R. A. De-graaf, High magnetic field water and metabolite proton T1 and T2 relaxation in rat brain in vivo, Magn. Reson Med, vol.56, issue.2, pp.386-394, 2006.

D. S. Grebenkov, NMR survey of reflected Brownian motion, Rev. Mod. Phys, vol.79, issue.3, pp.1077-1137, 2007.

I. Grundke-iqbal, Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology, Proc. Natl. Acad. Sci. U. S. A, vol.83, issue.13, pp.4913-4917, 1986.

E. L. Hahn, Spin echoes, Phys. Rev, vol.77, issue.5, pp.746-746, 1950.

J. M. Hakumaki, T. R. Pirttila, and R. A. Kauppinen, Reduction in water and metabolite apparent diffusion coefficients during energy failure involves cation-dependent mechanisms. A proton nuclear magnetic resonance study of rat cortical brain slices, J. Cereb. Blood Flow. Metab, vol.20, issue.2, pp.405-411, 2000.

M. Harada, Diffusion-weighted in vivo localized proton MR spectroscopy of human cerebral ischemia and tumor, Nmr Biomed, vol.15, issue.1, pp.69-74, 2002.

A. Ianus, D. C. Alexander, and I. Drobnjak, Microstructure imaging sequence simulation toolbox, Lect. Notes Comput. Sc, vol.9968, pp.34-44, 2016.

H. Jara and F. W. Wehrli, Determination of background gradients with diffusion MR imaging, J. Magn. Reson Imaging, vol.4, issue.6, pp.787-797, 1994.

S. N. Jespersen, C. D. Kroenke, L. Ostergaard, J. J. Ackerman, and D. A. Yablonskiy, Modeling dendrite density from magnetic resonance diffusion measurements, Neuroimage, vol.34, issue.4, pp.1473-1486, 2007.

S. N. Jespersen, H. Lundell, C. K. Sonderby, and T. B. Dyrby, Orientationally invariant metrics of apparent compartment eccentricity from double pulsed field gradient diffusion experiments, Nmr Biomed, vol.26, issue.12, pp.1647-1662, 2013.

H. E. Kan, Differences in apparent diffusion coefficients of brain metabolites between grey and white matter in the human brain measured at 7 T, Magn. Reson Med, vol.67, issue.5, pp.1203-1209, 2012.

J. Keeler, Understanding NMR Spectroscopy, 2011.

V. G. Kiselev, Fundamentals of diffusion MRI physics, Nmr Biomed, vol.30, issue.3, 2017.

M. A. Koch and J. Finsterbusch, Towards compartment size estimation in vivo based on double wave vector diffusion weighting, Nmr Biomed, vol.24, issue.10, pp.1422-1432, 2011.

C. D. Kroenke, J. J. Ackerman, and J. J. Neil, Magnetic resonance measurement of tetramethylammonium diffusion in rat brain: comparison of magnetic resonance and ionophoresis in vivo diffusion measurements, Magn. Reson Med, vol.50, issue.4, pp.717-726, 2003.

C. D. Kroenke, J. J. Ackerman, and D. A. Yablonskiy, On the nature of the NAA diffusion attenuated MR signal in the central nervous system, Magn. Reson Med, vol.52, issue.5, pp.1052-1059, 2004.

B. Kunnecke, S. Cerdan, and J. Seelig, Cerebral metabolism of [1,2-13C2]glucose and [U-13C4]3-hydroxybutyrate in rat brain as detected by 13C NMR spectroscopy, Nmr Biomed, vol.6, issue.4, pp.264-277, 1993.

B. Lampinen, Neurite density imaging versus imaging of microscopic anisotropy in diffusion MRI: a model comparison using spherical tensor encoding, Neuroimage, vol.147, pp.517-531, 2017.

L. L. Latour, K. Svoboda, P. P. Mitra, and C. H. Sotak, Time-dependent diffusion of water in a biological model system, P Natl. Acad. Sci. U. S. A, vol.91, issue.4, pp.1229-1233, 1994.

M. Lawrenz and J. Finsterbusch, Double-wave-vector diffusion-weighted imaging reveals microscopic diffusion anisotropy in the living human brain, Magn. Reson Med, vol.69, issue.4, pp.1072-1082, 2013.

M. Lawrenz, S. Brassen, and J. Finsterbusch, Microscopic diffusion anisotropy in the human brain: reproducibility, normal values, and comparison with the fractional anisotropy, Neuroimage, vol.109, pp.283-297, 2015.

P. L. Lee and R. G. Gonzalez, Magnetic resonance spectroscopy of brain tumors, Curr. Opin. Oncol, vol.12, issue.3, pp.199-204, 2000.

C. Ligneul and J. Valette, Probing metabolite diffusion at ultra-short time scales in the mouse brain using optimized oscillating gradients and "short"-echo-time diffusionweighted MRS, Nmr Biomed, vol.30, issue.1, 2017.
URL : https://hal.archives-ouvertes.fr/cea-01752157

C. Ligneul, M. Palombo, and J. Valette, Metabolite diffusion up to very high b in the mouse brain in vivo: revisiting the potential correlation between relaxation and diffusion properties, Magn. Reson Med, vol.77, issue.4, pp.1390-1398, 2017.
URL : https://hal.archives-ouvertes.fr/cea-02155304

P. Linse and O. Soderman, The validity of the short-gradient-pulse approximation in Nmr-studies of restricted diffusion -simulations of molecules diffusing between planes, in cylinders and spheres, J. Magn. Reson Ser. A, vol.116, issue.1, pp.77-86, 1995.

N. F. Lori, Diffusion tensor fiber tracking of human brain connectivity: acquisition methods, reliability analysis and biological results, Nmr Biomed, vol.15, issue.7-8, pp.494-515, 2002.

H. Lundell, C. Ingo, T. B. Dyrby, and I. Ronen, Accurate estimation of intra-axonal diffusivity and anisotropy of NAA in humans at 7T, Proc. Intl. Soc. Mag. Reson. Med, vol.25, 2017.

I. Lundgaard, M. J. Osorio, B. T. Kress, S. Sanggaard, and M. Nedergaard, White matter astrocytes in health and disease, Neuroscience, vol.276, pp.161-173, 2014.

A. Mackay, In vivo visualization of myelin water in brain by magnetic resonance, Magn. Reson Med, vol.31, issue.6, pp.673-677, 1994.

S. Mangia, Metabolic and hemodynamic events after changes in neuronal activity: current hypotheses, theoretical predictions and in vivo NMR experimental findings, J. Cereb. Blood Flow. Metab, vol.29, issue.3, pp.441-463, 2009.

C. Marchadour, E. Brouillet, P. Hantraye, V. Lebon, and J. Valette, Anomalous diffusion of brain metabolites evidenced by diffusion-weighted magnetic resonance spectroscopy in vivo, J. Cereb. Blood Flow. Metab, vol.32, issue.12, pp.2153-2160, 2012.

K. D. Merboldt, D. Horstermann, W. Hanicke, H. Bruhn, and J. Frahm, Molecular selfdiffusion of intracellular metabolites in rat brain in vivo investigated by localized proton NMR diffusion spectroscopy, Magn. Reson Med, vol.29, issue.1, pp.125-129, 1993.

S. Mierisova, New approach for quantitation of short echo time in vivo 1H MR spectra of brain using AMARES, Nmr Biomed, vol.11, issue.1, pp.32-39, 1998.

P. P. Mitra, Multiple wave-vector extensions of the Nmr pulsed-field-gradient spinecho diffusion measurement, Phys. Rev. B, vol.51, issue.21, pp.15074-15078, 1995.

P. P. Mitra, P. N. Sen, and L. M. Schwartz, Short-time behavior of the diffusioncoefficient as a geometrical probe of porous-media, Phys. Rev. B, vol.47, issue.14, pp.8565-8574, 1993.

G. R. Molloy, C. D. Wilson, P. Benfield, J. De-vellis, and S. Kumar, Rat brain creatine kinase messenger RNA levels are high in primary cultures of brain astrocytes and oligodendrocytes and low in neurons, J. Neurochem, vol.59, issue.5, pp.1925-1932, 1992.

C. T. Moonen, P. C. Van-zijl, D. Le-bihan, and D. Despres, In vivo NMR diffusion spectroscopy: 31P application to phosphorus metabolites in muscle, Magn. Reson Med, vol.13, issue.3, pp.467-477, 1990.
URL : https://hal.archives-ouvertes.fr/hal-00350078

S. Mori and P. C. Van-zijl, Fiber tracking: principles and strategies -a technical review, Nmr Biomed, vol.15, issue.7-8, pp.468-480, 2002.
DOI : 10.1002/nbm.781

K. F. Morris and C. S. Johnson, Resolution of discrete and continuous molecular-size distributions by means of diffusion-ordered 2d Nmr-spectroscopy, J. Am. Chem. Soc, vol.115, issue.10, pp.4291-4299, 1993.

M. E. Moseley, Diffusion-weighted MR imaging of acute stroke: correlation with T2-weighted and magnetic susceptibility-enhanced MR imaging in cats, AJNR Am. J. Neuroradiol, vol.11, issue.3, pp.423-429, 1990.

C. Najac, Intracellular metabolites in the primate brain are primarily localized in long fibers rather than in cell bodies, as shown by diffusion-weighted magnetic resonance spectroscopy, Neuroimage, vol.90, pp.374-380, 2014.

C. Najac, F. Branzoli, I. Ronen, and J. Valette, Brain intracellular metabolites are freely diffusing along cell fibers in grey and white matter, as measured by diffusionweighted MR spectroscopy in the human brain at 7 T, Brain Struct. Funct, vol.221, issue.3, pp.1245-1254, 2016.

M. Neeman, J. P. Freyer, and L. O. Sillerud, A simple method for obtaining cross-termfree images for diffusion anisotropy studies in NMR microimaging, Magn. Reson Med, vol.21, issue.1, pp.138-143, 1991.

K. Nicolay, A. Van-der-toorn, and R. M. Dijkhuizen, In vivo diffusion spectroscopy. An overview, Nmr Biomed, vol.8, issue.7-8, pp.365-374, 1995.

K. Nicolay, K. P. Braun, R. A. Graaf, R. M. Dijkhuizen, and M. J. Kruiskamp, Diffusion NMR spectroscopy, Nmr Biomed, vol.14, issue.2, pp.94-111, 2001.

F. Nicoli, Metabolic counterpart of decreased apparent diffusion coefficient during hyperacute ischemic stroke -a brain proton magnetic resonance spectroscopic imaging study, Stroke, vol.34, issue.7, pp.82-87, 2003.

M. Nilsson, Noninvasive mapping of water diffusional exchange in the human brain using filter-exchange imaging, Magn. Reson Med, vol.69, issue.6, pp.1573-1581, 2013.

M. Nilsson, S. Lasic, I. Drobnjak, D. Topgaard, and C. F. Westin, Resolution limit of cylinder diameter estimation by diffusion MRI: the impact of gradient waveform and orientation dispersion, Nmr Biomed, vol.30, issue.7, p.3711, 2017.

K. Nordengen, C. Heuser, J. E. Rinholm, R. Matalon, and V. Gundersen, Localisation of N-acetylaspartate in oligodendrocytes/myelin, Brain Struct. Funct, vol.220, issue.2, pp.899-917, 2015.

D. S. Novikov and V. G. Kiselev, Surface-to-volume ratio with oscillating gradients, J. Magn. Reson, vol.210, issue.1, pp.141-145, 2011.
DOI : 10.1016/j.jmr.2011.02.011
URL : http://arxiv.org/pdf/1101.2669

D. S. Novikov, J. H. Jensen, J. A. Helpern, and E. Fieremans, Revealing mesoscopic structural universality with diffusion, P Natl. Acad. Sci. U. S. A, vol.111, issue.14, pp.5088-5093, 2014.
DOI : 10.1073/pnas.1316944111
URL : https://www.pnas.org/content/pnas/111/14/5088.full.pdf

N. A. Oberheim, Uniquely hominid features of adult human astrocytes, J. Neurosci, vol.29, issue.10, pp.3276-3287, 2009.
DOI : 10.1523/jneurosci.4707-08.2009
URL : http://www.jneurosci.org/content/29/10/3276.full.pdf

G. Oeltzschner, Dual-volume excitation and parallel reconstruction for Jdifference-edited MR spectroscopy, Magn. Reson Med, vol.77, issue.1, pp.16-22, 2017.
DOI : 10.1002/mrm.26536
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422131

R. J. Ordidge, A. Connelly, and J. A. Lohman, Image-selected invivo spectroscopy (isis) -a new technique for spatially selective Nmr-spectroscopy, J. Magn. Reson, vol.66, issue.2, pp.283-294, 1986.

E. Ozarslan, N. Shemesh, and P. J. Basser, A general framework to quantify the effect of restricted diffusion on the NMR signal with applications to double pulsed field gradient NMR experiments, J. Chem. Phys, vol.130, issue.10, 2009.

M. Palombo, New paradigm to assess brain cell morphology by diffusionweighted MR spectroscopy in vivo, Proc. Natl. Acad. Sci. U. S. A, vol.113, issue.24, pp.6671-6676, 2016.
DOI : 10.1073/pnas.1504327113
URL : https://hal.archives-ouvertes.fr/cea-02155309

M. Palombo, C. Ligneul, and J. Valette, Modeling diffusion of intracellular metabolites in the mouse brain up to very high diffusion-weighting: diffusion in long fibers (almost) accounts for non-monoexponential attenuation, Magn. Reson Med, vol.77, issue.1, pp.343-350, 2017.
URL : https://hal.archives-ouvertes.fr/cea-01751423

O. A. Petroff, L. Pleban, and J. W. Prichard, Metabolic assessment of a neuron-enriched fraction of rat cerebrum using high-resolution 1H and 13C NMR spectroscopy, Magn. Reson Med, vol.30, issue.5, pp.559-567, 1993.

J. Pfeuffer, I. Tkac, and R. Gruetter, Extracellular-intracellular distribution of glucose and lactate in the rat brain assessed noninvasively by diffusion-weighted 1H nuclear magnetic resonance spectroscopy in vivo, J. Cereb. Blood Flow. Metab, vol.20, issue.4, pp.736-746, 2000.

S. Posse, C. A. Cuenod, and D. Le-bihan, Human brain: proton diffusion MR spectroscopy, Radiology, vol.188, issue.3, pp.719-725, 1993.
DOI : 10.1148/radiology.188.3.8351339
URL : https://hal.archives-ouvertes.fr/hal-00350007

W. S. Price, NMR Studies of Translational Motion: Principles and Applications, 2009.

W. S. Price, B. E. Chapman, B. A. Cornell, and P. W. Kuchel, Translational diffusion of Glycine in erythrocytes measured at high-resolution with pulsed field gradients, J. Magn. Reson, vol.83, issue.1, pp.160-166, 1989.

S. W. Provencher, Estimation of metabolite concentrations from localized in vivo proton NMR spectra, Magn. Reson Med, vol.30, issue.6, pp.672-679, 1993.

I. Ronen and J. Valette, Diffusion-weighted magnetic resonance spectroscopy, vol.4, pp.733-750, 2015.

I. Ronen, E. Ercan, and A. Webb, Axonal and glial microstructural information obtained with diffusion-weighted magnetic resonance spectroscopy at 7T, Front. Integr. Neurosci, vol.7, p.13, 2013.

I. Ronen, Microstructural organization of axons in the human corpus callosum quantified by diffusion-weighted magnetic resonance spectroscopy of Nacetylaspartate and post-mortem histology, Brain Struct. Funct, vol.219, issue.5, pp.1773-1785, 2014.

D. L. Rothman, In vivo nuclear magnetic resonance spectroscopy studies of the relationship between the glutamate-glutamine neurotransmitter cycle and functional neuroenergetics, Philos. Trans. R. Soc. Lond B Biol. Sci, vol.354, pp.1165-1177, 1387.

G. Schlaug, B. Siewert, A. Benfield, R. R. Edelman, and S. Warach, Time course of the apparent diffusion coefficient (ADC) abnormality in human stroke, Neurology, vol.49, issue.1, pp.113-119, 1997.

P. N. Sen, Time-dependent diffusion coefficient as a probe of geometry, Concept Magn. Reson A, vol.23, issue.1, pp.1-21, 2004.

N. Shemesh and Y. Cohen, The effect of experimental parameters on the signal decay in double-PGSE experiments: negative diffractions and enhancement of structural information, J. Magn. Reson, vol.195, issue.2, pp.153-161, 2008.

M. Palombo, NeuroImage, pp.1-20, 2017.

N. Shemesh and Y. Cohen, Overcoming apparent Susceptibility-Induced Anisotropy (aSIA) by bipolar double-Pulsed-Field-Gradient NMR, J. Magn. Reson, vol.212, issue.2, pp.362-369, 2011.
DOI : 10.1016/j.jmr.2011.07.015

N. Shemesh, E. Ozarslan, T. Adiri, P. J. Basser, and Y. Cohen, Noninvasive bipolar double-pulsed-field-gradient NMR reveals signatures for pore size and shape in polydisperse, randomly oriented, inhomogeneous porous media, J. Chem. Phys, vol.133, issue.4, 2010.

N. Shemesh, T. Adiri, and Y. Cohen, Probing microscopic architecture of opaque heterogeneous systems using double-pulsed-field-gradient NMR, J. Am. Chem. Soc, vol.133, issue.15, pp.6028-6035, 2011.

N. Shemesh, E. Ozarslan, P. J. Basser, and Y. Cohen, Accurate noninvasive measurement of cell size and compartment shape anisotropy in yeast cells using double-pulsed field gradient MR, Nmr Biomed, vol.25, issue.2, pp.236-246, 2012.

N. Shemesh, J. T. Rosenberg, J. N. Dumez, S. C. Grant, and L. Frydman, Metabolic T1 dynamics and longitudinal relaxation enhancement in vivo at ultrahigh magnetic fields on ischemia, J. Cereb. Blood Flow. Metab, vol.34, issue.11, pp.1810-1817, 2014.

N. Shemesh, Metabolic properties in stroked rats revealed by relaxationenhanced magnetic resonance spectroscopy at ultrahigh fields, Nat. Commun, vol.5, 2014.

N. Shemesh, J. T. Rosenberg, J. Dumez, L. Frydman, and S. C. Grant, Resolving cellular specific microarchitectures using double pulsed field gradient weighted, relaxation-enhanced magnetic resonance spectroscopy, Proc. Intl. Soc. Mag. Reson. Med, vol.23, 2015.

N. Shemesh, Conventions and nomenclature for double diffusion encoding NMR and MRI, Magn. Reson Med, vol.75, issue.1, pp.82-87, 2016.
DOI : 10.1002/mrm.25901
URL : https://onlinelibrary.wiley.com/doi/pdf/10.1002/mrm.25901

M. L. Simmons, C. G. Frondoza, and J. T. Coyle, Immunocytochemical localization of Nacetyl-aspartate with monoclonal antibodies, Neuroscience, vol.45, issue.1, pp.37-45, 1991.

O. Soderman and B. Jonsson, Restricted diffusion in cylindrical geometry, J. Magn. Reson Ser. A, vol.117, issue.1, pp.94-97, 1995.

E. O. Stejskal and J. E. Tanner, Spin diffusion measurements: spin echoes in the presence of a time-dependent field gradient, J. Chem. Phys, vol.42, issue.1, p.288, 1965.

J. Stepisnik, Time-dependent self-diffusion by Nmr spin-echo, Phys. B-Condensed Matter, vol.183, issue.4, pp.343-350, 1993.

I. Tkac, G. Oz, G. Adriany, K. Ugurbil, and R. Gruetter, In vivo 1H NMR spectroscopy of the human brain at high magnetic fields: metabolite quantification at 4T vs. 7T, Magn. Reson Med, vol.62, issue.4, pp.868-879, 2009.

A. Van-der-toorn, R. M. Dijkhuizen, C. A. Tulleken, and K. Nicolay, Diffusion of metabolites in normal and ischemic rat brain measured by localized 1H MRS, Magn. Reson Med, vol.36, issue.6, pp.914-922, 1996.

J. Upadhyay, K. Hallock, K. Erb, D. S. Kim, and I. Ronen, Diffusion properties of NAA in human corpus callosum as studied with diffusion tensor spectroscopy, Magn. Reson Med, vol.58, issue.5, pp.1045-1053, 2007.

J. Upadhyay, K. Hallock, M. Ducros, D. S. Kim, and I. Ronen, Diffusion tensor spectroscopy and imaging of the arcuate fasciculus, Neuroimage, vol.39, issue.1, pp.1-9, 2008.

J. Valette, Optimized diffusion-weighted spectroscopy for measuring brain glutamate apparent diffusion coefficient on a whole-body MR system, Nmr Biomed, vol.18, issue.8, pp.527-533, 2005.

J. Valette, A new sequence for single-shot diffusion-weighted NMR spectroscopy by the trace of the diffusion tensor, Magn. Reson Med, vol.68, issue.6, pp.1705-1712, 2012.

P. Vangelderen, Water diffusion and acute stroke, Magn. Reson Med, vol.31, issue.2, pp.154-163, 1994.

L. Vanhamme, S. Van-huffel, P. Van-hecke, and D. Van-ormondt, Time-domain quantification of series of biomedical magnetic resonance spectroscopy signals, J. Magn. Reson, vol.140, issue.1, pp.120-130, 1999.

P. C. Vanzijl, Complete separation of intracellular and extracellular information in Nmr-spectra of perfused cells by diffusion-weighted spectroscopy, P Natl. Acad. Sci. U. S. A, vol.88, issue.8, pp.3228-3232, 1991.

A. Verkhratsky, V. Parpura, M. Pekna, M. Pekny, and M. Sofroniew, Glia in the pathogenesis of neurodegenerative diseases, Biochem. Soc. Trans, vol.42, issue.5, pp.1291-1301, 2014.

M. Wick, Y. Nagatomo, F. Prielmeier, and J. Frahm, Alteration of intracellular metabolite diffusion in rat brain in vivo during ischemia and reperfusion, Stroke, vol.26, issue.10, 1930.

J. P. Wijnen, 1D diffusion weighted magnetic resonance spectroscopy along the arcuate fasiculus in the human brain at 7T. Int. Soc. Magnetic Reson, p.694, 2014.

M. Wilson, G. Reynolds, R. A. Kauppinen, T. N. Arvanitis, and A. C. Peet, A constrained least-squares approach to the automated quantitation of in vivo (1)H magnetic resonance spectroscopy data, Magn. Reson Med, vol.65, issue.1, pp.1-12, 2011.

E. T. Wood, Investigating axonal damage in multiple sclerosis by diffusion tensor spectroscopy, J. Neurosci, vol.32, issue.19, pp.6665-6669, 2012.
DOI : 10.1523/jneurosci.0044-12.2012
URL : http://www.jneurosci.org/content/32/19/6665.full.pdf

E. T. Wood, Longitudinal MR spectroscopy of neurodegeneration in multiple sclerosis with diffusion of the intra-axonal constituent N-acetylaspartate, Neuroimage Clin, vol.15, pp.780-788, 2017.

D. A. Yablonskiy and A. L. Sukstanskii, Theoretical models of the diffusion weighted MR signal, Nmr Biomed, vol.23, issue.7, pp.661-681, 2010.

T. Yoshiura, O. Wu, A. Zaheer, T. G. Reese, and A. G. Sorensen, Highly diffusionsensitized MRI of brain: dissociation of gray and white matter, Magn. Reson Med, vol.45, issue.5, pp.734-740, 2001.

H. Zhang, T. Schneider, C. A. Wheeler-kingshott, and D. C. Alexander, NODDI: practical in vivo neurite orientation dispersion and density imaging of the human brain, Neuroimage, vol.61, issue.4, pp.1000-1016, 2012.

G. Zheng and W. S. Price, Suppression of background gradients in (B-0 gradient-based) NMR diffusion experiments, Concept Magn. Reson A, vol.30, issue.5, pp.261-277, 2007.

D. D. Zheng, Z. H. Liu, J. Fang, X. Y. Wang, and J. Zhang, The effect of age and cerebral ischemia on diffusion-weighted proton MR spectroscopy of the human brain, AJNR Am. J. Neuroradiol, vol.33, issue.3, pp.563-568, 2012.