Metabolite diffusion up to very high b in the mouse brain in vivo: Revisiting the potential correlation between relaxation and diffusion properties - Archive ouverte HAL Access content directly
Journal Articles Magnetic Resonance in Medicine Year : 2017

Metabolite diffusion up to very high b in the mouse brain in vivo: Revisiting the potential correlation between relaxation and diffusion properties

(1) , (1) , (1)
1

Abstract

Purpose: To assess the potential correlation between metabo-lites diffusion and relaxation in the mouse brain, which is of importance for interpreting and modeling metabolite diffusion based on pure geometry, irrespective of relaxation properties (multicompartmental relaxation or surface relaxivity). Methods: A new diffusion-weighted magnetic resonance spec-troscopy sequence is introduced, dubbed "STE-LASER," which presents several nice properties, in particular the absence of cross-terms with selection gradients and a very clean localiza-tion. Metabolite diffusion is then measured in a large voxel in the mouse brain at 11.7 Tesla using a cryoprobe, resulting in excellent signal-to-noise ratio, up to very high b-values under different echo time, mixing time, and diffusion time combinations. Results: Our results suggest that the correlation between relaxation and diffusion properties is extremely small or even nonexistent for metabolites in the mouse brain. Conclusion: The present work strongly supports the interpretation and modeling of metabolite diffusion primarily based on geometry, irrespective of relaxation properties, at least under current experimental conditions.
Fichier principal
Vignette du fichier
ligneul_MRM_2016.pdf (1.5 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

cea-02155304 , version 1 (13-06-2019)

Licence

Attribution - CC BY 4.0

Identifiers

Cite

Clémence Ligneul, Marco Palombo, Julien Valette. Metabolite diffusion up to very high b in the mouse brain in vivo: Revisiting the potential correlation between relaxation and diffusion properties. Magnetic Resonance in Medicine, 2017, 77 (4), pp.1390-1398. ⟨10.1002/mrm.26217⟩. ⟨cea-02155304⟩
56 View
78 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More