Carbonylation of C-N Bonds in Tertiary Amines Catalyzed by Low Valent Iron Catalysts

Tawfiq Nasr Allah; Solène Savourey; Jean-Claude Berthet; Emmanuel Nicolas; Thibault Cantat

doi:10.1002/anie.201903740

Journal articles

Carbonylation of C-N Bonds in Tertiary Amines Catalyzed by Low Valent Iron Catalysts

Tawfiq Nasr Allah ¹ Solène Savourey ¹ Jean-Claude Berthet ¹ Emmanuel Nicolas ¹ Thibault Cantat ^{1, *}

* Corresponding author

1 LCMCE - Laboratoire de Chimie Moléculaire et de Catalyse pour l'Energie (ex LCCEF)

NIMBE UMR 3685 - Nanosciences et Innovation pour les Matériaux, la Biomédecine et l'Energie (ex SIS2M)

Abstract : The first iron catalysts able to promote the formal insertion of CO into the C-N bond of amines are reported. Using low valent iron complexes, including K2[Fe(CO)4], amides are formed from aromatic and aliphatic amines, in the presence of an iodoalkane promoter. Inorganic Lewis acids, such as AlCl3 and Nd(OTf)3, have a positive influence on the catalytic activity of the iron salts, enabling the carbonylation at a low pressure of CO (6 to 8 bars).

Keywords : Amides Lewis Acids Catalysis Carbon Monoxide Iron

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Journal articles

Domain :

Chemical Sciences / Organic chemistry

Chemical Sciences / Catalysis

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