The complex STATes of astrocyte reactivity: How are they controlled by the JAK–STAT3 pathway?

Kelly Ceyzériat 1 Laurene Abjean 1 Maria-Angeles Carrillo-de Sauvage 1 Lucile Ben Haim 1, 2 Carole Escartin 1, *
* Corresponding author
1 LMN - Laboratoire des Maladies Neurodégénératives - UMR 9199
MIRCEN - Service MIRCEN : DRF/JACOB, UP11 - Université Paris-Sud - Paris 11, CNRS - Centre National de la Recherche Scientifique : UMR 9199
Abstract : Astrocytes play multiple important roles in brain physiology. In pathological conditions, they become reac-tive, which is characterized by morphological changes and upregulation of intermediate filament proteins. Besides these descriptive hallmarks, astrocyte reactivity involves significant transcriptional and functional changes that are far from being fully understood. Most importantly, astrocyte reactivity seems to encompass multiple states, each having a specific influence on surrounding cells and disease progression. These diverse functional states of reactivity must be regulated by subtle signaling networks. Many signaling cascades have been associated with astrocyte reactivity, but among them, the JAK-STAT3 pathway is emerging as a central regulator. In this review, we aim (i) to show that the JAK-STAT3 pathway plays a key role in the control of astrocyte reactivity, (ii) to illustrate that STAT3 is a pleiotropic molecule operating multiple functions in reactive astrocytes, and (iii) to suggest that each specific functional state of reactivity is governed by complex molecular interactions within astrocytes, which converge on STAT3. More research is needed to precisely identify the signaling networks controlling the diverse states of astro-cyte reactivity. Only then, we will be able to precisely delin-eate the therapeutic potential of reactive astrocytes in each neurological disease context. Ó
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Kelly Ceyzériat, Laurene Abjean, Maria-Angeles Carrillo-de Sauvage, Lucile Ben Haim, Carole Escartin. The complex STATes of astrocyte reactivity: How are they controlled by the JAK–STAT3 pathway?. Neuroscience, Elsevier - International Brain Research Organization, 2016, 330, pp.205-218. ⟨10.1016/j.neuroscience.2016.05.043⟩. ⟨cea-02142559⟩

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