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, Christoph Schüller and Thomas Nyström are acknowledged for comments on the manuscript and we thank Anders Blomberg and Gustav Ammerer for support throughout this study. We are also grateful to Dorothea Anrather and David Hollenstein for help with MS analyses

F. Eisele, T. Tatsuta, and T. Langer, Joseph Heitman and Joakim Norbeck for providing reagents, and the Centre of Cellular Imaging, Sahlgrenska Academy, for the use of imaging equipment and support from the staff. The Olympus Cell^R microscope was purchased with support from Ingabritt och Arne Lundbergs stiftelse, This work was supported by grants from the Swedish Research Council (to M.M.), by the foundations of Olle Engkvist Byggmästare and Carl Trygger (to M.M.), by the Knut and Alice Wallenberg foundation (to M.K.) and by ANR ERRed and PLBIO INCA_5869