Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents - Archive ouverte HAL Access content directly
Journal Articles Nature Communications Year : 2017

Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents

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Michael N Smolka
  • Function : Author
Brian Knutson
  • Function : Author

Abstract

Novelty-seeking tendencies in adolescents may promote innovation as well as problematic impulsive behaviour, including drug abuse. Previous research has not clarified whether neural hyper- or hyporesponsiveness to anticipated rewards promotes vulnerability in these individuals. Here we use a longitudinal design to track 144 novelty-seeking adolescents at age 14 and 16 to determine whether neural activity in response to anticipated rewards predicts problematic drug use. We find that diminished BOLD activity in mesolimbic (ventral striatal and midbrain) and prefrontal cortical (dorsolateral prefrontal cortex) regions during reward anticipation at age 14 predicts problematic drug use at age 16. Lower psychometric conscientiousness and steeper discounting of future rewards at age 14 also predicts problematic drug use at age 16, but the neural responses independently predict more variance than psychometric measures. Together, these findings suggest that diminished neural responses to anticipated rewards in novelty-seeking adolescents may increase vulnerability to future problematic drug use.
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Dates and versions

cea-02138905 , version 1 (24-05-2019)

Licence

Attribution - CC BY 4.0

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Cite

Christian Büchel, Jan Peters, Tobias Banaschewski, Arun Bokde, Uli Bromberg, et al.. Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents. Nature Communications, 2017, 8, pp.14140. ⟨10.1038/ncomms14140⟩. ⟨cea-02138905⟩
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