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Journal articles
Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents
Christian Büchel
1
Jan Peters
2
Tobias Banaschewski
3
Arun Bokde
4
Uli Bromberg
5
Patricia Conrod
6
Herta Flor
7
Dimitri Papadopoulos
8
Hugh Garavan
9
Penny Gowland
10
Andreas Heinz
11
Henrik Walter
11
Bernd Ittermann
11
Karl Mann
7
Jean-Luc Martinot
12
Luise Poustka
7
Marcella Rietschel
13
Trevor Robbins
14
Michael Smolka
Juergen Gallinat
11
Gunter Schumann
15
Brian Knutson
Christian Büchel 1
Author
Jan Peters 2
Author
Tobias Banaschewski 3
Author Employer institution : Central Institute of Mental Health Mannheim
Arun Bokde 4
Author
Uli Bromberg 5
Author
Patricia J Conrod 6
Author
Herta Flor 7
Author
Dimitri Papadopoulos 8
Author IdHAL : dimitri-papadopoulos-orfanos ORCID : https://orcid.org/0000-0002-1242-8990
Bernd Ittermann 11
Author
Karl Mann 7
Author
Jean-Luc Martinot 12
Author Employer institution : Institut National de la Santé et de la Recherche Médicale
Luise Poustka 7
Author
Marcella Rietschel 13
Author Employer institution : Central Institute of Mental Health Mannheim
Trevor W. Robbins 14
Author
Michael N Smolka
Author
Juergen Gallinat 11
Author
Gunter Schumann 15
Author
Brian Knutson
Author
2
IAS - Intelligent Autonomous Systems (France)
- TU Darmstadt - Technische Universität Darmstadt (Karolinenplatz 5, 64289 Darmstadt - Germany)
3
Department of Child and Adolescent Psychiatry and Psychotherapy [Mannheim] (Square J5 - 68159 Mannheim - Germany)
- Universität Heidelberg [Heidelberg] ( Seminarstraße 2, 69117 Heidelberg - Germany)
4
Trinity College Dublin (College Green, Dublin 2, Ireland - Ireland)
5
UKE - Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (Martinistraße 52
20251 Hamburg - Germany)
6
Institute of Psychiatry, Psychology & Neuroscience, King's College London (Institute of Psychiatry, Psychology & Neuroscience King's College London 16 De Crespigny Park London SE5 8AF - United Kingdom)
- King‘s College London (Strand Campus, London WC2R 2LS - United Kingdom)
7
Universität Mannheim [Mannheim] (Schloss, 68131 Mannheim - Germany)
8
NEUROSPIN - Service NEUROSPIN (France)
- DRF (CEA) - Direction de Recherche Fondamentale (CEA) : DRF/JOLIOT (Direction de Recherche Fondamentale
Fundamental Research Division
CEA Saclay
91191 Gif-sur-Yvette
- France)
- CEA - Commissariat à l'énergie atomique et aux énergies alternatives (Centre de Saclay Centre de Grenoble Centre de Cadarache etc - France)
- Université Paris-Saclay (Espace Technologique, Bat. Discovery - RD 128 - 2e ét., 91190 Saint-Aubin - France)
9
University of Vermont [Burlington] (Burlington, VT 05405 - United States)
10
Sir Peter Mansfield Magnetic Resonance Centre [Nottingham] (Nottingham
NG7 2RD - United Kingdom)
- UON - University of Nottingham, UK (University of Nottingham University Park Nottingham NG7 2RD - United Kingdom)
11
Charité - Universitätsmedizin Berlin / Charite - University Medicine Berlin (Charitéplatz, 10117 Berlin - Germany)
12
U1000 - Neuroimagerie en psychiatrie (CEA - Service Hospitalier Frédéric Joliot 4, place du Général Leclerc 91401 Orsay Cedex - France)
- UP11 - Université Paris-Sud - Paris 11 : UMR_S 1000 (Bâtiment 300 - 91405 Orsay cedex - France)
- CEA - Commissariat à l'énergie atomique et aux énergies alternatives : UMR_S 1000 (Centre de Saclay Centre de Grenoble Centre de Cadarache etc - France)
- UPD5 - Université Paris Descartes - Paris 5 : UMR_S 1000 (12, rue de l'École de Médecine - 75270 Paris cedex 06 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1000 (101, rue de Tolbiac, 75013 Paris - France)
13
Department of Genetic Epidemiology in Psychiatry [Mannhein] (Mannheim - Germany)
- Universität Heidelberg [Heidelberg] ( Seminarstraße 2, 69117 Heidelberg - Germany)
- Central Institute of Mental Health Mannheim (Germany)
14
Department of Experimental Psychology (United Kingdom)
- CAM - University of Cambridge [UK] (The Old Schools, Trinity Lane, Cambridge CB2 1TN - United Kingdom)
15
Göttingen Zentrum Geowissenschaften (Abteilung Geobiologie, Goldschmidtstrasse 3, D-37077 Göttingen - Germany)
- Georg-August-Universität Göttingen = University of Göttingen (Wilhelmsplatz 1 (Aula) 37073 Göttingen - Germany)
Abstract : Novelty-seeking tendencies in adolescents may promote innovation as well as problematic impulsive
behaviour, including drug abuse. Previous research has not clarified whether neural hyper- or hyporesponsiveness to anticipated rewards promotes vulnerability in these individuals. Here we use a
longitudinal design to track 144 novelty-seeking adolescents at age 14 and 16 to determine whether
neural activity in response to anticipated rewards predicts problematic drug use. We find that
diminished BOLD activity in mesolimbic (ventral striatal and midbrain) and prefrontal cortical
(dorsolateral prefrontal cortex) regions during reward anticipation at age 14 predicts problematic
drug use at age 16. Lower psychometric conscientiousness and steeper discounting of future rewards
at age 14 also predicts problematic drug use at age 16, but the neural responses independently
predict more variance than psychometric measures. Together, these findings suggest that diminished
neural responses to anticipated rewards in novelty-seeking adolescents may increase vulnerability to
future problematic drug use.
Document type :
Journal articles
Domain :
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https://hal-cea.archives-ouvertes.fr/cea-02138905
Contributor : Bruno Savelli <>
Submitted on : Friday, May 24, 2019 - 11:31:47 AM
Last modification on : Wednesday, October 14, 2020 - 3:40:09 AM
Contributor : Bruno Savelli <>
Submitted on : Friday, May 24, 2019 - 11:31:47 AM
Last modification on : Wednesday, October 14, 2020 - 3:40:09 AM
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Distributed under a Creative Commons Attribution 4.0 International License
Identifiers
- HAL Id : cea-02138905, version 1
- DOI : 10.1038/ncomms14140
Collections
CEA | UNIV-PARIS5 | JOLIOT | CEA-DRF | NEUROSPIN | USPC | UNIV-PARIS-SACLAY | CEA-UPSAY | UNIV-PARIS
Citation
Christian Büchel, Jan Peters, Tobias Banaschewski, Arun Bokde, Uli Bromberg, et al.. Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents. Nature Communications, Nature Publishing Group, 2017, 8, pp.14140. ⟨10.1038/ncomms14140⟩. ⟨cea-02138905⟩
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