 |
Journal articles
Efficient Access to Deuterated and Tritiated Nucleobase Pharmaceuticals and Oligonucleotides using Hydrogen-Isotope Exchange
Abstract : A general approach for the efficient hydrogen-isotope exchange of nucleobase derivatives is described. Catalyzed by ruthenium nanoparticles, using mild reaction conditions, and involving either D2 or T2 as isotopic sources, this reaction possesses a wide substrate scope and a high solvent tolerability. This novel method facilitates the access to essential diagnostic tools in drug discovery and development: tritiated pharmaceuticals with high specific activities and deuterated oligonucleotides suitable for use as internal standards during LC-MS quantification.
Cited literature [28 references]
https://hal-cea.archives-ouvertes.fr/cea-02075752
Contributor : Marianne Leriche Connect in order to contact the contributor
Submitted on : Thursday, March 21, 2019 - 3:44:49 PM
Last modification on : Tuesday, October 19, 2021 - 11:17:40 PM
Long-term archiving on: : Saturday, June 22, 2019 - 3:20:02 PM
Contributor : Marianne Leriche Connect in order to contact the contributor
Submitted on : Thursday, March 21, 2019 - 3:44:49 PM
Last modification on : Tuesday, October 19, 2021 - 11:17:40 PM
Long-term archiving on: : Saturday, June 22, 2019 - 3:20:02 PM
File
Final manuscript ACIE 20181394...
Files produced by the author(s)
Licence
Distributed under a Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International License