Abstract : This article reports an efficient CH activation process for regioselective halogenation of 1,4-benzodiazepinones. Direct halogenation with NXS (X = Br, I) affords halogenated benzodiazepinones on the central aromatic ring whereas catalyst (Pd(OAc) 2) controlled CH activation furnishes regioselectively ortho halogenated benzodiazepinones on the phenyl side chain.
https://hal-cea.archives-ouvertes.fr/cea-02075732
Contributor : Marianne Leriche
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Submitted on : Thursday, March 21, 2019 - 3:37:22 PM
Last modification on : Saturday, March 23, 2019 - 1:23:09 AM
