Regioselective Halogenation of 1,4-Benzodiazepinones via CH Activation

Abstract : This article reports an efficient CH activation process for regioselective halogenation of 1,4-benzodiazepinones. Direct halogenation with NXS (X = Br, I) affords halogenated benzodiazepinones on the central aromatic ring whereas catalyst (Pd(OAc) 2) controlled CH activation furnishes regioselectively ortho halogenated benzodiazepinones on the phenyl side chain.
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Hajer Abdelkafi, Jean-Christophe Cintrat. Regioselective Halogenation of 1,4-Benzodiazepinones via CH Activation. Scientific Reports, Nature Publishing Group, 2015, 5 (1), ⟨10.1038/srep12131⟩. ⟨cea-02075732⟩

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