Abstract : This article reports an efficient CH activation process for regioselective halogenation of 1,4-benzodiazepinones. Direct halogenation with NXS (X = Br, I) affords halogenated benzodiazepinones on the central aromatic ring whereas catalyst (Pd(OAc) 2) controlled CH activation furnishes regioselectively ortho halogenated benzodiazepinones on the phenyl side chain.
https://hal-cea.archives-ouvertes.fr/cea-02075732 Contributor : Marianne LericheConnect in order to contact the contributor Submitted on : Thursday, March 21, 2019 - 3:37:22 PM Last modification on : Monday, December 13, 2021 - 9:15:17 AM