Skip to Main content Skip to Navigation
Journal articles

Regioselective Halogenation of 1,4-Benzodiazepinones via CH Activation

Abstract : This article reports an efficient CH activation process for regioselective halogenation of 1,4-benzodiazepinones. Direct halogenation with NXS (X = Br, I) affords halogenated benzodiazepinones on the central aromatic ring whereas catalyst (Pd(OAc) 2) controlled CH activation furnishes regioselectively ortho halogenated benzodiazepinones on the phenyl side chain.
Document type :
Journal articles
Complete list of metadatas

Cited literature [39 references]  Display  Hide  Download

https://hal-cea.archives-ouvertes.fr/cea-02075732
Contributor : Marianne Leriche <>
Submitted on : Thursday, March 21, 2019 - 3:37:22 PM
Last modification on : Wednesday, July 8, 2020 - 3:37:15 AM

File

srep12131.pdf
Files produced by the author(s)

Identifiers

Citation

Hajer Abdelkafi, Jean-Christophe Cintrat. Regioselective Halogenation of 1,4-Benzodiazepinones via CH Activation. Scientific Reports, Nature Publishing Group, 2015, 5 (1), ⟨10.1038/srep12131⟩. ⟨cea-02075732⟩

Share

Metrics

Record views

123

Files downloads

184