Current strategies for brain drug delivery, Theranostics, vol.8, pp.1481-1493, 2018. ,
Apical ABC transporters and cancer chemotherapeutic drug disposition, Adv. Cancer Res, vol.125, pp.1-41, 2015. ,
The blood-brain barrier and cancer: transporters, treatment, and Trojan horses, Clin. Cancer Res, vol.13, pp.1663-1674, 2007. ,
From blood-brain barrier to blood-brain interface: new opportunities for CNS drug delivery, Nat. Rev. Drug Discov, vol.15, pp.275-292, 2016. ,
Structure and function of the blood-brain barrier, Neurobiol. Dis, vol.37, pp.13-25, 2010. ,
Into rather unexplored terrain-transcellular transport across the blood-brain barrier, Glia, vol.64, pp.1097-1123, 2016. ,
Astrocyte-endothelial interactions at the blood-brain barrier, Nat. Rev. Neurosci, vol.7, pp.41-53, 2006. ,
Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels, Mol. Pharm, vol.8, pp.1332-1341, 2011. ,
Preclinical comparison of osimertinib with other EGFR-TKIs in EGFR-mutant NSCLC brain metastases models, and early evidence of clinical brain metastases activity, Clin. Cancer Res, vol.22, pp.5130-5140, 2016. ,
Brain and testis accumulation of regorafenib is restricted by breast cancer resistance protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1), Pharm. Res, vol.32, pp.2205-2216, 2015. ,
Kinetic analysis of the cooperation of P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp/Abcg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone, J. Pharmacol. Exp. Ther, vol.333, pp.788-796, 2010. ,
,
, Journal of Controlled Release, vol.292, pp.210-220, 2018.
, New Drugs, vol.30, pp.443-449, 2012.
Function of the blood-brain barrier and restriction of drug delivery to invasive glioma cells: findings in an orthotopic rat xenograft model of glioma, Drug Metab. Dispos, vol.41, pp.33-39, 2013. ,
Acquired resistance to TKIs in solid tumours: learning from lung cancer, Nat. Rev. Clin. Oncol, vol.11, pp.473-481, 2014. ,
Targeting EGFR for treatment of glioblastoma: molecular basis to overcome resistance, Curr. Cancer Drug Targets, vol.12, pp.197-209, 2012. ,
Delivery of molecularly targeted therapy to malignant glioma, a disease of the whole brain, Expert Rev. Mol. Med, vol.13, 2011. ,
Pulsatile erlotinib in EGFR-positive non-small-cell lung cancer patients with leptomeningeal and brain metastases: review of the literature, Clin. Lung Cancer, vol.18, pp.354-363, 2017. ,
Review of ultrasound mediated drug delivery for cancer treatment: updates from pre-clinical studies, Transl. Cancer Res, vol.3, pp.494-511, 2014. ,
Combining microbubbles and ultrasound for drug delivery to brain tumors: current progress and overview, Theranostics, vol.4, pp.432-444, 2014. ,
Noninvasive MR imagingguided focal opening of the blood-brain barrier in rabbits, Radiology, vol.220, pp.640-646, 2001. ,
Targeted drug delivery across the blood-brain barrier using ultrasound technique, Ther. Deliv, vol.1, pp.819-848, 2010. ,
The threshold for brain damage in rabbits induced by bursts of ultrasound in the presence of an ultrasound contrast agent (Optison), Ultrasound Med. Biol, vol.29, pp.473-481, 2003. ,
Clinical trial of blood-brain barrier disruption by pulsed ultrasound, Sci. Transl. Med, vol.8, pp.343-345, 2016. ,
Complex interplay between the P-glycoprotein multidrug efflux pump and the membrane: its role in modulating protein function, Front. Oncol, vol.4, 2014. ,
Overcoming the blood-brain tumor barrier for effective glioblastoma treatment, Drug Resist. Updat, vol.19, pp.1-12, 2015. ,
Acute effects of focused ultrasound-induced increases in blood-brain barrier permeability on rat microvascular transcriptome, Sci. Rep, vol.7, 2017. ,
Effects on Pglycoprotein expression after blood-brain barrier disruption using focused ultrasound and microbubbles, PLoS One, vol.12, p.166061, 2017. ,
Localized down-regulation of P-glycoprotein by focused ultrasound and microbubbles induced blood-brain barrier disruption in rat brain, Sci. Rep, vol.6, p.31201, 2016. ,
Imaging techniques to study drug transporter function in vivo, Pharmacol. Ther, vol.189, pp.104-122, 2018. ,
URL : https://hal.archives-ouvertes.fr/cea-01943448
Imaging the function of P-glycoprotein with radiotracers: pharmacokinetics and in vivo applications, Clin. Pharmacol. Ther, vol.86, pp.368-377, 2009. ,
Breast cancer resistance protein and P-glycoprotein influence in vivo disposition of 11C-erlotinib, J. Nucl. Med, vol.56, pp.1930-1936, 2015. ,
Strategies to inhibit ABCB1-and ABCG2mediated efflux transport of erlotinib at the blood-brain barrier: a PET study on nonhuman primates, J. Nucl. Med, vol.58, pp.117-122, 2017. ,
Molecular imaging of ABCB1/ABCG2 inhibition at the human blood brain barrier using elacridar and 11C-erlotinib PET, J. Nucl. Med, vol.59, pp.973-975, 2018. ,
Intravenous infusion for the controlled exposure to the dual ABCB1 and ABCG2 inhibitor elacridar in nonhuman primates, Drug Deliv. Transl. Res, vol.8, pp.536-542, 2018. ,
Imaging the impact of the P-glycoprotein (ABCB1) function on the brain kinetics of metoclopramide, J. Nucl. Med, vol.57, pp.309-314, 2016. ,
Development of [(11)C]erlotinib positron emission tomography for in vivo evaluation of EGF receptor mutational status, Clin. Cancer Res, vol.19, pp.183-193, 2013. ,
Imaging the impact of cyclosporin A and dipyridamole on P-glycoprotein (ABCB1) function at the blood-brain barrier: a [(11)C]-N-desmethyl-loperamide PET study in nonhuman primates, Eur. J. Pharm. Sci, vol.91, pp.98-104, 2016. ,
Acoustic transmission factor through the rat skull as a function of body mass, frequency and position, Ultrasound Med. Biol, 2018. ,
URL : https://hal.archives-ouvertes.fr/cea-02043267
Magnetic resonance-guided motorized transcranial ultrasound system for blood-brain barrier permeabilization along arbitrary trajectories in rodents, J. Ther. Ultrasound, vol.3, 2015. ,
URL : https://hal.archives-ouvertes.fr/cea-02043280
Dynamic study of blood-brain barrier closure after its disruption using ultrasound: a quantitative analysis, J. Cereb. Blood Flow Metab, vol.32, pp.1948-1958, 2012. ,
URL : https://hal.archives-ouvertes.fr/cea-00739117
A simple method for quantifying ultrasound-triggered microbubble destruction, Ultrasound Med. Biol, vol.37, pp.949-957, 2011. ,
The "specific" P-glycoprotein inhibitor Tariquidar is also a substrate and an inhibitor for breast cancer resistance protein (BCRP/ABCG2), ACS Chem. Neurosci, vol.2, pp.82-89, 2011. ,
Safety validation of repeated blood-brain barrier disruption using focused ultrasound, Ultrasound Med. Biol, vol.42, pp.481-492, 2016. ,
Impact of rifampicin-inhibitable transport on the liver distribution and tissue kinetics of erlotinib assessed with PET imaging in rats, EJNMMI Res, vol.8, 2018. ,
N-desmethyl-loperamide is selective for P-glycoprotein among three ATP-binding cassette transporters at the blood-brain barrier, Drug Metab. Dispos, vol.38, pp.917-922, 2010. ,
Spatial resolution and sensitivity of the Inveon small-animal PET scanner, J. Nucl. Med, vol.50, pp.139-147, 2009. ,
Erlotinib accumulation in brain metastases from non-small cell lung cancer: visualization by positron emission tomography in a patient harboring a mutation in the epidermal growth factor receptor, J. Thorac. Oncol, vol.6, pp.1287-1289, 2011. ,
Imaging P-glycoprotein function in rats using, Ann. Nucl. Med, vol.27, issue.11, pp.618-624, 2013. ,
Blood-brain barrier, cytotoxic chemotherapies and glioblastoma, Expert. Rev. Neurother, vol.16, pp.1285-1300, 2016. ,
Effect of the ATPbinding cassette drug transporters ABCB1, ABCG2, and ABCC2 on erlotinib hydrochloride (Tarceva) disposition in in vitro and in vivo pharmacokinetic studies employing Bcrp1?/?/Mdr1a/1b?/? (triple-knockout) and wild-type mice, Mol. Cancer Ther, vol.7, pp.2280-2287, 2008. ,
Clinical pharmacokinetics of an amorphous solid dispersion tablet of elacridar, Drug Deliv. Transl. Res, vol.7, pp.125-131, 2017. ,
Increased permeability-glycoprotein inhibition at the human blood-brain barrier can be safely achieved by performing PET during peak plasma concentrations of tariquidar, J. Nucl. Med, vol.56, pp.82-87, 2015. ,
P-glycoprotein function at the blood-brain barrier imaged using 11C-N-desmethyl-loperamide in monkeys, J. Nucl. Med, vol.50, pp.108-115, 2009. ,
Factors governing P-glycoprotein-mediated drug-drug interactions at the blood-brain barrier measured with positron emission tomography, Mol. Pharm, vol.12, pp.3214-3225, 2015. ,
, Journal of Controlled Release, vol.292, pp.210-220, 2018.
Clinical safety of SonoVue, a new contrast agent for ultrasound imaging, in healthy volunteers and in patients with chronic obstructive pulmonary disease, Investig. Radiol, vol.36, pp.104-109, 2001. ,
Hemorrhage detection during focused-ultrasound induced blood-brain-barrier opening by using susceptibility-weighted magnetic resonance imaging, Ultrasound Med. Biol, vol.34, pp.598-606, 2008. ,
Ultrasound-induced mild hyperthermia improves the anticancer efficacy of both Taxol® and paclitaxel-loaded nanocapsules, J. Control. Release, vol.264, pp.219-227, 2017. ,
URL : https://hal.archives-ouvertes.fr/cea-02043274
Medicinal chemical properties of successful central nervous system drugs, NeuroRx, vol.2, pp.541-553, 2005. ,
Current status and future perspectives of sonodynamic therapy in glioma treatment, Ultrason. Sonochem, vol.37, pp.592-599, 2017. ,
Differences in gadolinium retention after repeated injections of macrocyclic MR contrast agents to rats, J. Magn. Reson. Imaging, vol.47, pp.746-752, 2018. ,
Interactions of tyrosine kinase inhibitors with organic cation transporters and multidrug and toxic compound extrusion proteins, Mol. Cancer Ther, vol.10, pp.531-539, 2011. ,
Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function, J. Med. Chem, vol.51, pp.6034-6043, 2008. ,
Evaluation of permeability, doxorubicin delivery, and drug retention in a rat brain tumor model after ultrasound-induced blood-tumor barrier disruption, J. Control. Release, vol.250, pp.77-85, 2017. ,
Experimental study on targeted methotrexate delivery to the rabbit brain via magnetic resonance imagingguided focused ultrasound, J. Ultrasound Med, vol.28, pp.871-880, 2009. ,
Focused ultrasound-induced bloodbrain barrier disruption enhances the delivery of cytarabine to the rat brain, J. Chemother, vol.24, pp.358-363, 2012. ,
Enhanced brain distribution of carboplatin in a primate model after blood-brain barrier disruption using an implantable ultrasound device, Cancer Chemother. Pharmacol, vol.77, pp.211-216, 2016. ,
Ultrasound-induced opening of the blood-brain barrier to enhance temozolomide and irinotecan delivery: an experimental study in rabbits, J. Neurosurg, vol.124, pp.1602-1610, 2016. ,
Revisiting the role of ABC transporters in multidrug-resistant cancer, Nat. Rev. Cancer, vol.1, 2018. ,
Localized doxorubicin chemotherapy with a biopolymeric nanocarrier improves survival and reduces toxicity in xenografts of human breast cancer, J. Control. Release, vol.146, pp.212-218, 2010. ,
Brainstem blood brain barrier disruption using focused ultrasound: a demonstration of feasibility and enhanced doxorubicin delivery, J. Control. Release, vol.281, pp.29-41, 2018. ,
Screening of multidrugresistance sensitive drugs by in situ brain perfusion in P-glycoprotein-deficient mice, Pharm. Res, vol.18, pp.183-190, 2001. ,
Tariquidar and elacridar are dose-dependently transported by P-glycoprotein and Bcrp at the blood-brain barrier: a small-animal positron emission tomography and in vitro study, Drug Metab, vol.41, pp.754-762, 2013. ,
Brain distribution and bioavailability of elacridar after different routes of administration in the mouse, Drug Metab. Dispos, vol.40, pp.1612-1619, 2012. ,
Regulation of ABC transporters at the blood-brain barrier, Clin. Pharmacol. Ther, vol.97, pp.395-403, 2015. ,
Alterations in pericyte subpopulations are associated with elevated blood-tumor barrier permeability in experimental brain metastasis of breast cancer, Clin. Cancer Res, vol.22, pp.5287-5299, 2016. ,
Weak base permeability characteristics influence the intracellular sequestration site in the multidrug-resistant human leukemic cell line HL-60, J. Biol. Chem, vol.279, pp.32367-32372, 2004. ,
Quantitative fluorescence microscopy provides high resolution imaging of passive diffusion and P-gp mediated efflux at the in vivo blood-brain barrier, J. Neurosci. Methods, vol.219, pp.188-195, 2013. ,
Pglycoprotein mediated efflux limits substrate and drug uptake in a preclinical brain metastases of breast cancer model, Front. Pharmacol, vol.4, 2013. ,
Ultrasound-triggered drug delivery for cancer treatment using drug delivery systems: from theoretical considerations to practical applications, J. Control. Release, vol.241, pp.144-163, 2016. ,
Recent progress of drug nanoformulations targeting to brain, J. Control. Release, 2018. ,
Nanodrug delivery systems for targeting the endogenous tumor microenvironment and simultaneously overcoming multidrug resistance properties, J. Control. Release, vol.251, pp.49-67, 2017. ,
P-glycoprotein (ABCB1) inhibits the influx and increases the efflux of 11C-metoclopramide across the blood-brain barrier: a PET study on non-human primates, J. Nucl. Med, vol.59, pp.1609-1615, 2018. ,
URL : https://hal.archives-ouvertes.fr/cea-01818347
Insight into the cooperation of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) at the blood-brain barrier: a case study examining sorafenib efflux clearance, Mol. Pharm, vol.9, pp.678-684, 2012. ,