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Journal articles
TOR Signaling and Nutrient Sensing
Abstract : All living organisms rely on nutrients to sustain cell metabolism and energy production, which in turn need to be adjusted based on available resources. The evolutionarily conserved target of rapamycin (TOR) protein kinase is a central regulatory hub that connects environmental information about the quantity and quality of nutrients to developmental and metabolic processes in order to maintain cellular homeostasis. TOR is activated by both nitrogen and carbon metabolites and promotes energy-consuming processes such as cell division, mRNA translation, and anabolism in times of abundance while repressing nutrient remobilization through autophagy. In animals and yeasts, TOR acts antagonistically to the starvation-induced AMP-activated kinase (AMPK)/sucrose nonfermenting 1 (Snf1) kinase, called Snf1-related kinase 1 (SnRK1) in plants. This review summarizes the immense knowledge on the relationship betweenTORsignaling and nutrients in nonphotosynthetic organisms and presents recent findings in plants that illuminate the crucial role of this pathway in conveying nutrient-derived signals and regulating many aspects of metabolism and growth.
https://hal-cea.archives-ouvertes.fr/cea-02025859
Contributor : Alexandra Maraval Connect in order to contact the contributor
Submitted on : Tuesday, February 19, 2019 - 9:20:20 PM
Last modification on : Tuesday, November 16, 2021 - 8:42:01 AM
Contributor : Alexandra Maraval Connect in order to contact the contributor
Submitted on : Tuesday, February 19, 2019 - 9:20:20 PM
Last modification on : Tuesday, November 16, 2021 - 8:42:01 AM