Heritability of surface area and cortical thickness: a comparison between the Human Connectome Project and the UK Biobank dataset

Yann Le Guen 1 Slim Karkar 1 Antoine Grigis 1 Cathy Philippe 1 Jean-François Mangin 1 Vincent Frouin 1, *
* Corresponding author
1 UNATI - Unité Analyse et Traitement de l'Information
Abstract : Heritability of the regional thickness/surface in human cortex is established. Yet the estimates vary substantially depending on cohorts or the information they are derived from: pedigree or genotyping. Here we present three heritability studies of the cortex phenotype in two cohorts showing: i) both pedigree and genotyping or ii) genotyping only. We obtained clearly correlated heritability values between studies with a shift appearing between cohorts. Spatial pattern of heritability remains highly consistent across cohorts
Keywords : imaging-genetic heritability cortical thickness surface area
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Conference papers
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Yann Le Guen, Slim Karkar, Antoine Grigis, Cathy Philippe, Jean-François Mangin, et al.. Heritability of surface area and cortical thickness: a comparison between the Human Connectome Project and the UK Biobank dataset. ISBI 2019 - Proceedings of the IEEE International Symposium on Biomedical Imaging, 2019, Venice, Italy. ⟨cea-02016831⟩

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