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Heritability of surface area and cortical thickness: a comparison between the Human Connectome Project and the UK Biobank dataset

Abstract : Heritability of the regional thickness/surface in human cortex is established. Yet the estimates vary substantially depending on cohorts or the information they are derived from: pedigree or genotyping. Here we present three heritability studies of the cortex phenotype in two cohorts showing: i) both pedigree and genotyping or ii) genotyping only. We obtained clearly correlated heritability values between studies with a shift appearing between cohorts. Spatial pattern of heritability remains highly consistent across cohorts
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https://hal-cea.archives-ouvertes.fr/cea-02016831
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Submitted on : Tuesday, February 12, 2019 - 10:44:09 PM
Last modification on : Tuesday, March 24, 2020 - 2:46:12 PM
Long-term archiving on: : Monday, May 13, 2019 - 6:29:46 PM

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  • HAL Id : cea-02016831, version 1

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Yann Le Guen, Slim Karkar, Antoine Grigis, Cathy Philippe, Jean-François Mangin, et al.. Heritability of surface area and cortical thickness: a comparison between the Human Connectome Project and the UK Biobank dataset. ISBI 2019 - Proceedings of the IEEE International Symposium on Biomedical Imaging, 2019, Venice, Italy. ⟨cea-02016831⟩

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