Sydnone-based Approach to Hetero-helicenes Through 1,3-Dipolar-Cycloadditions
Abstract
The first approach to pyrazole containing helicenes via sydnone-aryne [3+2]-cycloaddition is described. An unprecedented regioselectivity in the cycloaddition step towards the more sterically constrained product was observed in presence of extended aromatic scaffolds. DFT calculations enabled to understand the origin of this unexpected selectivity.
Domains
Organic chemistry
Origin : Files produced by the author(s)
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