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Imaging probes and modalities for the study of Solute Carrier O (SLCO)-transport function in vivo

Abstract : Transporters of the Solute Carrier O (SLCO) family, former organic anion-transporting polypeptides (OATP), are now recognized as key players in pharmacokinetics. Imaging is increasingly regarded as a relevant method to elucidate and decipher the intrinsic role of SLCO in controlling drug disposition in plasma and tissues. Current research in this representative field of translational research is based on different imaging modalities including nuclear imaging, such as Single Photon Emission Computed Tomography (SPECT) or Positron Emission Tomography (PET), as well as Magnetic Resonance Imaging (MRI). Imaging modalities can be compared in terms of sensitivity, quantitative properties, spatial resolution, variety of ligands and radiation exposure. All of these approaches rely on the use of SLCO-substrates that are detected using corresponding modalities. The present review aims at reporting and comparing the imaging probes that have been proposed to study SLCO-transport function, in terms of $in\ vitro$ specificity, $in\ vivo$ behavior and clinical validation.
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Submitted on : Wednesday, December 19, 2018 - 3:33:29 PM
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Marie et al. Accepted version....
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Solène Marie, Salvatore Cisternino, Irene Buvat, Xavier Declèves, Nicolas Tournier. Imaging probes and modalities for the study of Solute Carrier O (SLCO)-transport function in vivo. Journal of Pharmaceutical Sciences, 2017, 106 (9), pp.2335-2344. ⟨10.1016/j.xphs.2017.04.031⟩. ⟨cea-01960787⟩



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