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Copper-Catalyzed Aza-Iminosydnone-Alkyne Cycloaddition Reaction Discovered by Screening

Elodie Decuypere 1 Sabrina Bernard 1 Minghao Feng 1 Karine Porte 1 Margaux Riomet 1 Pierre Thuéry 2 Davide Audisio 1 Frédéric Taran 1, * 
* Corresponding author
2 LCMCE - Laboratoire de Chimie Moléculaire et de Catalyse pour l'Energie (ex LCCEF)
NIMBE UMR 3685 - Nanosciences et Innovation pour les Matériaux, la Biomédecine et l'Energie (ex SIS2M)
Abstract : The chemistry and reactivity of mesoionic compounds represent a chemical space largely unexploited. Using a MS-based screening approach, the reactivity of mesoionics toward terminal alkynes under copper catalysis has been explored. This approach led to the discovery of new reactions allowing chemoselective ligation of the two reaction partners and, simultaneously, the release of a fragment molecule. The reactivity of aza-iminosydnones allowing the selective formation of 1,2,3 triazoles or hydrazineylidene-propanal derivatives from alkynes was revealed. This copper-catalyzed reaction was found to be under the control of copper-ligand and alkyne structures. The scope of the reactions and mechanistic investigations are presented.
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Submitted on : Friday, December 7, 2018 - 8:49:50 AM
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Elodie Decuypere, Sabrina Bernard, Minghao Feng, Karine Porte, Margaux Riomet, et al.. Copper-Catalyzed Aza-Iminosydnone-Alkyne Cycloaddition Reaction Discovered by Screening. ACS Catalysis, American Chemical Society, 2018, 8, pp.11882-11888. ⟨10.1021/acscatal.8b03492⟩. ⟨cea-01944398⟩



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