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Physiological Roles of Plant Methionine Sulfoxide Reductases in Redox Homeostasis and Signaling

Pascal Rey 1, 2, * Lionel Tarrago 3, *
* Corresponding author
2 LEMP - Laboratoire d'Ecophysiologie Moléculaire des Plantes
DRF (CEA) - Direction de Recherche Fondamentale (CEA) : DRF/BIAM, AMU - Aix Marseille Université, CNRS - Centre National de la Recherche Scientifique
3 MEM - Microbiologie Environnementale et Moléculaire
BIAM - Institut de Biosciences et Biotechnologies d'Aix-Marseille (ex-IBEB) : DRF/BIAM
Abstract : Oxidation of methionine (Met) leads to the formation of two S- and R-diastereoisomers of Met sulfoxide (MetO) that are reduced back to Met by methionine sulfoxide reductases (MSRs), A and B, respectively. Here, we review the current knowledge about the physiological functions of plant MSRs in relation with subcellular and tissue distribution, expression patterns, mutant phenotypes, and possible targets. The data gained from modified lines of plant models and crop species indicate that MSRs play protective roles upon abiotic and biotic environmental constraints. They also participate in the control of the ageing process, as shown in seeds subjected to adverse conditions. Significant advances were achieved towards understanding how MSRs could fulfil these functions via the identification of partners among Met-rich or MetO-containing proteins, notably by using redox proteomic approaches. In addition to a global protective role against oxidative damage in proteins, plant MSRs could specifically preserve the activity of stress responsive effectors such as glutathione-S-transferases and chaperones. Moreover, several lines of evidence indicate that MSRs fulfil key signaling roles via interplays with Ca$^{2+}$- and phosphorylation-dependent cascades, thus transmitting ROS-related information in transduction pathways.
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Submitted on : Monday, December 3, 2018 - 3:30:58 PM
Last modification on : Tuesday, October 19, 2021 - 10:59:05 PM


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Pascal Rey, Lionel Tarrago. Physiological Roles of Plant Methionine Sulfoxide Reductases in Redox Homeostasis and Signaling. Antioxidants , MDPI, 2018, 7, pp.114. ⟨10.3390/antiox7090114⟩. ⟨cea-01939384⟩



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