M. Hollstein, ) p53 mutations in human cancers, Science, vol.253, pp.49-53, 1991.

A. J. Levine, The p53 tumour suppressor gene, Nature, vol.351, pp.453-456, 1991.

A. J. Levine, ) p53, the cellular gatekeeper for growth and division, Cell, vol.88, pp.323-331, 1997.

S. M. Purandare and P. I. Patel, Recombination hot spots and human disease, Genome Res, vol.7, pp.773-786, 1997.
DOI : 10.1101/gr.7.8.773
URL : http://genome.cshlp.org/content/7/8/773.full.pdf

K. M. Haigis and W. F. Dove, A Robertsonian translocation suppresses a somatic recombination pathway to loss of heterozygosity, Nat. Genet, vol.33, pp.33-39, 2003.

M. Amor, Mutation in the CYP21B gene (Ile-172-Asn) causes steroid 21-hydroxylase deficiency, Proc. Natl. Acad. Sci. U. S. A, vol.85, pp.1600-1604, 1988.

S. Gangloff, Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases, Nat. Genet, vol.25, pp.192-194, 2000.

Y. Saintigny, Homologous recombination resolution defect in Werner syndrome, Mol. Cell. Biol, vol.22, pp.6971-6978, 2002.
URL : https://hal.archives-ouvertes.fr/cea-01938137

J. Dominguez-bendala, Elevated expression of exogenous Rad51 leads to identical increases in gene-targeting frequency in murine embryonic stem (ES) cells with both functional and dysfunctional p53 genes, Exp. Cell Res, vol.286, pp.298-307, 2003.

M. I. Aladjem, ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage, Curr. Biol, vol.8, pp.145-155, 1998.

L. Wiesmuller, In vivo assay of p53 function in homologous recombination between simian virus 40 chromosomes, J. Virol, vol.70, pp.737-744, 1996.

M. S. Meyn, Testing the role of p53 in the expression of genetic instability and apoptosis in ataxia-telangiectasia, Int. J. Radiat. Biol, vol.66, pp.141-149, 1994.

P. Bertrand, Increase of spontaneous intrachromosomal homologous recombination in mammalian cells expressing a mutant p53 protein, Oncogene, vol.14, pp.1117-1122, 1997.

K. L. Mekeel, Inactivation of p53 results in high rates of homologous recombination, Oncogene, vol.14, pp.1847-1857, 1997.

D. Gebow, Homologous and nonhomologous recombination resulting in deletion: effects of p53 status, microhomology, and repetitive DNA length and orientation, Mol. Cell. Biol, vol.20, pp.4028-4035, 2000.

X. Lu, Activities of wildtype and mutant p53 in suppression of homologous recombination as measured by a retroviral vector system, Mutat. Res, vol.522, pp.69-83, 2003.

A. J. Bishop, Atm-, p53-, and Gadd45a-deficient mice show an increased frequency of homologous recombination at different stages during development, Cancer Res, vol.63, pp.5335-5343, 2003.

Y. Saintigny, Mutant p53 proteins stimulate spontaneous and radiation-induced intrachromosomal homologous recombination independently of the alteration of the transactivation activity and of the G1 checkpoint, Oncogene, vol.18, pp.3553-3563, 1999.
URL : https://hal.archives-ouvertes.fr/cea-01938157

F. Paques and J. E. Haber, Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae. Microbiol, Mol. Biol. Rev, vol.63, pp.349-404, 1999.

S. Lambert and B. S. Lopez, Characterization of mammalian RAD51 double strand break repair using non lethal dominant negative forms, EMBO J, vol.19, pp.3090-3099, 2000.

F. Liang, Homology-directed repair is a major doublestrand break repair pathway in mammalian cells, Proc. Natl. Acad. Sci. U. S. A, vol.95, pp.5172-5177, 1998.

Y. Y. Wang, Carcinogens can induce homologous recombination between duplicated chromosomal sequences in mouse L cells, Mol. Cell. Biol, vol.8, pp.196-202, 1988.

N. Akyuz, DNA substrate dependence of p53-mediated regulation of double-strand break repair, Mol. Cell. Biol, vol.22, pp.6306-6317, 2002.

V. Gottifredi, accumulates but is functionally impaired when DNA synthesis is blocked, Proc. Natl. Acad. Sci. U. S. A, vol.98, pp.1036-1041, 2001.

C. Dudenhoffer, Dissociation of the recombination control and the sequence-specific transactivation function of P53, Oncogene, vol.18, pp.5773-5784, 1999.

H. Willers, Dissociation of p53-mediated suppression of homologous recombination from G1/S cell cycle checkpoint control, Oncogene, vol.19, pp.632-639, 2000.

G. S. Boehden, mutated in the transactivation domain retains regulatory functions in homology-directed double-strand break repair, Oncogene, vol.22, pp.4111-4117, 2003.

S. Sengupta, BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination, EMBO J, vol.22, pp.1210-1222, 2003.

S. P. Linke, interacts with hRAD51 and hRAD54, and directly modulates homologous recombination, Cancer Res, vol.63, pp.2596-2605, 2003.

M. M. Cox, The importance of repairing stalled replication forks, Nature, vol.404, pp.37-41, 2000.

B. Michel, Rescue of arrested replication forks by homologous recombination, Proc. Natl. Acad. Sci. U. S. A, vol.98, pp.8181-8188, 2001.

Y. Saintigny, Characterization of homologous recombination induced by replication inhibition in mammalian cells, EMBO J, vol.20, pp.3861-3870, 2001.

Y. Saintigny and B. S. Lopez, Homologous recombination induced by replication inhibition, is stimulated by expression of mutant p53, Oncogene, vol.21, pp.488-492, 2002.
URL : https://hal.archives-ouvertes.fr/cea-01938162

C. Janz and L. Wiesmuller, Wild-type p53 inhibits replicationassociated homologous recombination, Oncogene, vol.21, pp.5929-5933, 2002.

N. Albrechtsen, Maintenance of genomic integrity by p53: complementary roles for activated and non-activated p53, Oncogene, vol.18, pp.7706-7717, 1999.

S. Lee, Human p53 binds Holliday junctions strongly and facilitates their cleavage, J. Biol. Chem, vol.272, pp.7532-7539, 1997.

H. W. Sturzbecher, is linked directly to homologous recombination processes via RAD51/RecA protein interaction, EMBO J, vol.15, p.53, 1992.

S. Buchhop, Interaction of p53 with the human Rad51 protein, Nucleic Acids Res, vol.25, pp.3868-3874, 1997.

D. Yoon, inhibits strand exchange and replication fork regression promoted by human RAD51, J. Mol. Biol, vol.336, pp.639-654, 2004.

H. Willers, Homologous recombination in extrachromosomal plasmid substrates is not suppressed by p53, Carcinogenesis, vol.22, pp.1757-1763, 2001.

J. Jiricny and M. Nystrom-lahti, Mismatch repair defects in cancer, Curr. Opin. Genet. Dev, vol.10, pp.157-161, 2000.

D. Zink, Association of p53 and MSH2 with recombinative repair complexes during S phase, Oncogene, vol.21, pp.4788-4800, 2002.

S. Lee, and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches, Cell, vol.81, pp.1013-1020, 1995.

N. Degtyareva, Analysis of the binding of p53 to DNAs containing mismatched and bulged bases, J. Biol. Chem, vol.276, pp.8778-8784, 2001.

D. Subramanian and J. D. Griffith, Interactions between p53, hMSH2 -hMSH6 and HMG I(Y) on Holliday junctions and bulged bases, Nucleic Acids Res, vol.30, pp.2427-2434, 2002.

C. Dudenhoffer, Specific mismatch recognition in heteroduplex intermediates by p53 suggests a role in fidelity control of homologous recombination, Mol. Cell. Biol, vol.18, pp.5332-5342, 1998.

T. Mummenbrauer, Protein exhibits 3 0 -to-5 0 exonuclease activity, Cell, vol.85, pp.1089-1099, 1996.

S. Susse, Role of heteroduplex joints in the functional interactions between human Rad51 and wild-type p53, Oncogene, vol.19, pp.4500-4512, 2000.

G. Blander, Physical and functional interaction between p53 and the Werner's syndrome protein, J. Biol. Chem, vol.274, pp.29463-29469, 1999.

E. A. Spillare, -mediated apoptosis is attenuated in Werner syndrome cells, Genes Dev, vol.13, pp.1355-1360, 1999.

X. W. Wang, Functional interaction of p53 and BLM DNA helicase in apoptosis, J. Biol. Chem, vol.276, pp.32948-32955, 2001.

R. M. Brosh, Modulates the exonuclease activity of Werner syndrome protein, J. Biol. Chem, vol.276, pp.35093-35102, 2001.

Q. Yang, The processing of Holliday junctions by BLM and WRN helicases is regulated by p53, J. Biol. Chem, vol.277, pp.31980-31987, 2002.

A. S. Waldman and R. M. Liskay, Dependence of intrachromosomal recombination in mammalian cells on uninterrupted homology, Mol. Cell. Biol, vol.8, pp.5350-5357, 1988.

C. Rayssiguier, The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatchrepair mutants, Nature, vol.342, pp.396-401, 1989.

M. Radman and R. Wagner, Mismatch recognition in chromosomal interactions and speciation, Chromosoma, vol.102, pp.369-373, 1993.

G. S. Jimenez, A transactivation-deficient mouse model provides insights into Trp53 regulation and function, Nat. Genet, vol.26, pp.37-43, 2000.

P. Bertrand, Overexpression of mammalian Rad51 does not stimulate tumorigenesis while a dominant-negative Rad51 affects centrosome fragmentation, ploidy and stimulates tumorigenesis, in p53-defective CHO cells, Oncogene, vol.22, pp.7587-7592, 2003.

P. G. Komarov, A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy, Science, vol.285, pp.1733-1737, 1999.

C. Deng, Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control, Cell, vol.82, pp.675-684, 1995.

C. Richardson, Rad51 overexpression promotes alternative double-strand break repair pathways and genome instability, Oncogene, vol.23, pp.546-553, 2004.

E. Raderschall, Elevated levels of Rad51 recombination protein in tumor cells, Cancer Res, vol.62, pp.219-225, 2002.

D. L. Schaffner, Retention of p53val135 wild-type function in transgenic mice, Lab. Invest, vol.74, pp.1005-1011, 1996.

P. E. Cohen and J. W. Pollard, Regulation of meiotic recombination and prophase I progression in mammals, BioEssays, vol.23, pp.996-1009, 2001.

E. C. Friedberg, DNA Repair and Mutagenesis, 1995.

S. C. Kowalczykowski and A. K. Eggleston, Homologous pairing and DNA strand-exchange proteins, Annu. Rev. Biochem, vol.63, pp.991-1043, 1994.
DOI : 10.1146/annurev.bi.63.070194.005015

P. Sung, Catalysis of ATP-dependent homologous DNA pairing and strand exchange by yeast RAD51 protein, Science, vol.265, pp.1241-1243, 1994.

P. Baumann, Human Rad51 protein promotes ATPdependent homologous pairing and strand transfer reactions in vitro, Cell, vol.87, pp.757-766, 1996.
DOI : 10.1016/s0092-8674(00)81394-x
URL : https://doi.org/10.1016/s0092-8674(00)81394-x

J. W. Szostak, The double-strand-break repair model for recombination, Cell, vol.33, pp.25-35, 1983.

P. Mohaghegh and I. D. Hickson, DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders, Hum. Mol. Genet, vol.10, pp.741-746, 2001.
DOI : 10.1093/hmg/10.7.741
URL : https://academic.oup.com/hmg/article-pdf/10/7/741/9813641/100741.pdf