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Journal Articles Science of aging knowledge environment [electronic resource] : SAGE KE Year : 2004

Werner Syndrome Protein - Unwinding Function to Explain Disease

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Abstract

Werner syndrome (WS) is one of three heritable human genetic instability/cancer predisposition syndromes that result from mutations in a member of the gene family encoding human RecQ helicases. Cellular defects are a prominent part of the WS phenotype. Here we review recent work to identify in vi-vo functions of the WS protein and discuss how loss of function leads to cellular defects. These new results provide clues to the origin of cell lineage-specific defects in WS patients and suggest a broader role for Werner protein function in determining disease risk in the general population.
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cea-01938173 , version 1 (28-11-2018)

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  • HAL Id : cea-01938173 , version 1

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Raymond J. Monnat Jr., Yannick Saintigny. Werner Syndrome Protein - Unwinding Function to Explain Disease. Science of aging knowledge environment [electronic resource] : SAGE KE, 2004, 13, pp.re3. ⟨cea-01938173⟩

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