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Journal articles

Werner Syndrome Protein - Unwinding Function to Explain Disease

Abstract : Werner syndrome (WS) is one of three heritable human genetic instability/cancer predisposition syndromes that result from mutations in a member of the gene family encoding human RecQ helicases. Cellular defects are a prominent part of the WS phenotype. Here we review recent work to identify in vi-vo functions of the WS protein and discuss how loss of function leads to cellular defects. These new results provide clues to the origin of cell lineage-specific defects in WS patients and suggest a broader role for Werner protein function in determining disease risk in the general population.
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Contributor : Yannick Saintigny Connect in order to contact the contributor
Submitted on : Wednesday, November 28, 2018 - 2:53:18 PM
Last modification on : Friday, November 30, 2018 - 1:00:22 AM


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  • HAL Id : cea-01938173, version 1




Raymond J. Monnat Jr., yannick Saintigny. Werner Syndrome Protein - Unwinding Function to Explain Disease. Science of aging knowledge environment [electronic resource] : SAGE KE, 2004, 13, pp.re3. ⟨cea-01938173⟩



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