Werner Syndrome Protein - Unwinding Function to Explain Disease

Raymond J. Monnat Jr. (1) , Yannick Saintigny (2)

1 University of Washington [Seattle]
2 LMR - Laboratoire d'étude des Mécanismes de la recombinaison

Werner syndrome (WS) is one of three heritable human genetic instability/cancer predisposition syndromes that result from mutations in a member of the gene family encoding human RecQ helicases. Cellular defects are a prominent part of the WS phenotype. Here we review recent work to identify in vi-vo functions of the WS protein and discuss how loss of function leads to cellular defects. These new results provide clues to the origin of cell lineage-specific defects in WS patients and suggest a broader role for Werner protein function in determining disease risk in the general population.

Domains: Cancer

Raymond J. Monnat Jr., Yannick Saintigny. Werner Syndrome Protein - Unwinding Function to Explain Disease. Science of aging knowledge environment [electronic resource] : SAGE KE, 2004, 13, pp.re3. ⟨cea-01938173⟩