Dosimetry for radiobiology experiments at GANIL

Florent Durantel 1, * Emmanuel Balanzat 1 Amine Cassimi 1 François Chevalier 2 Yvette Ngono-Ravache 1 Toiammou Madi 1 Jean-Christophe Poully 1 Jean-Marc Ramillon 1 Hermann Rothard 1 Frédéric Ropars 1 Lucas Schwob 1 Isabelle Testard 3 Yannick Saintigny 2
* Corresponding author
1 CIMAP - UMR 6252 - Centre de recherche sur les Ions, les MAtériaux et la Photonique
2 LARIA - Laboratoire d'Accueil et de Recherche avec les Ions Accélérés
DRF (CEA) - Direction de Recherche Fondamentale (CEA) : DRF/JACOB/IRCM
3 LCBM - UMR 5249 - Laboratoire de Chimie et Biologie des Métaux
Abstract : Mainly encouraged by the increasing application of ion beams for cancer treatment (hadron-therapy) including carbon beams, the use of heavy ion facilities for radiobiology is expanding rapidly today. As an alternative to dedicated centers for treatment and medical research, accelerators like GANIL offer the possibility to undertake such experiments. Since 20 years, CIMAP, reinforced 15 years ago by the biological host laboratory LARIA, has been receiving researchers in radiobiology and assisted them in performing experiments in different fields such as hadron-therapy, space radioprotection and fundamental biological and physico-chemical mechanisms. We present here a short description of the beam line and the on-line equipments that allow the automatic irradiation of up to 24 biological samples at once. We also developed an original on-line beam monitoring procedure for low ion flux (low dose rates) based on the measurement of the K-shell X-rays emitted from a thin iron foil. This detector is calibrated on an absolute scale before each experiment by counting etched tracks on an irradiated CR39 polymer plate. We present the performances and limits of this method and finally give typical fluence (dose) uncertainties for a standard irradiation in radiobiology.
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CEA | DSM-IRAMIS | IRTSV-CBM | IRAMIS-CIMAP | INC-CNRS | COMUE-NORMANDIE | CEA-DRF | ENSICAEN | UNICAEN | BIG | UGA | UNIV-PARIS-SACLAY | IRIG | CEA-GRE

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Florent Durantel, Emmanuel Balanzat, Amine Cassimi, François Chevalier, Yvette Ngono-Ravache, et al.. Dosimetry for radiobiology experiments at GANIL. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Elsevier, 2016, 816, pp.70 - 77. ⟨10.1016/j.nima.2016.01.052⟩. ⟨cea-01938057⟩

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