In vitro engineering of human 3D chondrosarcoma: a preclinical model relevant for investigations of radiation quality impact

Abstract : Background: The benefit of better ballistic and higher efficiency of carbon ions for cancer treatment (hadron-therapy) is asserted since decades, especially for unresectable or resistant tumors like sarcomas. However, hadron-therapy with carbon ions stays underused and raises some concerns about potential side effects for patients. Chondrosarcoma is a cartilaginous tumor, chemo-and radiation-resistant, that lacks reference models for basic and pre-clinical studies in radiation-biology. Most studies about cellular effects of ionizing radiation, including hadrons, were performed under growth conditions dramatically different from human homeostasis. Tridimensional in vitro models are a fair alternative to animal models to approach tissue and tumors microenvironment.
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Dounia Hamdi, Sofia Barbieri, François Chevalier, Jean-Emmanuel Groetz, Florence Legendre, et al.. In vitro engineering of human 3D chondrosarcoma: a preclinical model relevant for investigations of radiation quality impact. BMC Cancer, BioMed Central, 2015, 15, pp.579. ⟨10.1186/s12885-015-1590-5⟩. ⟨cea-01938052⟩

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