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Comparable Senescence Induction in Three-dimensional Human Cartilage Model by Exposure to Therapeutic Doses of X-rays or C-ions

Abstract : The relative biological effectiveness of carbon ions compared with X-rays scored 2.6 in primary human artic-ular chondrocytes in Purpose: Particle therapy using carbon ions (C-ions) has been successfully used in the treatment of tumors resistant to conventional radiation therapy. However, the potential side effects to healthy cartilage exposed to lower linear energy transfer (LET) ions in the beam track before the tumor have not been evaluated. The aim of the present study was to assess the extent of damage after C-ion irradiation in a 3-dimensional (3D) cartilage model close to human homeostasis.
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Dounia Hamdi, François Chevalier, Jean-Emmanuel Groetz, Florent Durantel, Jean-Yves Thuret, et al.. Comparable Senescence Induction in Three-dimensional Human Cartilage Model by Exposure to Therapeutic Doses of X-rays or C-ions. International Journal of Radiation Oncology - Biology - Physics, Elsevier, 2016, 95 (1), pp.139 - 146. ⟨10.1016/j.ijrobp.2016.02.014⟩. ⟨cea-01938049⟩

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