Comparable Senescence Induction in Three-dimensional Human Cartilage Model by Exposure to Therapeutic Doses of X-rays or C-ions

Dounia Hamdi (1) , François Chevalier (1) , Jean-Emmanuel Groetz (2) , Florent Durantel (3) , Jean-Yves Thuret (4) , Carl Mann (5) , Yannick Saintigny (1)

1 LARIA - Laboratoire d'Accueil et de Recherche avec les Ions Accélérés
2 LCE - Laboratoire Chrono-environnement (UMR 6249)
3 CIMAP - UMR 6252 - Centre de recherche sur les Ions, les MAtériaux et la Photonique
4 FRE 3377 - Génétique moléculaire et destin cellulaire
5 SEN - Sénescence et stabilité génomique

The relative biological effectiveness of carbon ions compared with X-rays scored 2.6 in primary human artic-ular chondrocytes in Purpose: Particle therapy using carbon ions (C-ions) has been successfully used in the treatment of tumors resistant to conventional radiation therapy. However, the potential side effects to healthy cartilage exposed to lower linear energy transfer (LET) ions in the beam track before the tumor have not been evaluated. The aim of the present study was to assess the extent of damage after C-ion irradiation in a 3-dimensional (3D) cartilage model close to human homeostasis.

Domains: Life Sciences [q-bio]; Cancer; Physics [physics]; Physics [physics]; Medical Physics [physics.med-ph]

Dounia Hamdi, François Chevalier, Jean-Emmanuel Groetz, Florent Durantel, Jean-Yves Thuret, et al.. Comparable Senescence Induction in Three-dimensional Human Cartilage Model by Exposure to Therapeutic Doses of X-rays or C-ions. International Journal of Radiation Oncology, Biology, Physics, 2016, 95 (1), pp.139 - 146. ⟨10.1016/j.ijrobp.2016.02.014⟩. ⟨cea-01938049⟩