# Synthesis of Cryptophane-B. Crystal Structure and Study of its Complex with Xenon.

3 LSDRM - Laboratoire Structure et Dynamique par Résonance Magnétique (LCF)
NIMBE UMR 3685 - Nanosciences et Innovation pour les Matériaux, la Biomédecine et l'Energie (ex SIS2M)
Abstract : Whereas the synthesis of the $anti$-cryptophane-A (1) derivative is known for nearly 40 years, the preparation of its diastereomer (cryptophane-B according to Collet's nomenclature) has never been reported. Thus, the synthesis of the cryptophane-B derivative represents a real challenge for chemists interested in the preparation of these hollow molecules. Herein, we describe a synthetic route that allows us to prepare cryptophane-B (2), however in low yield. The X-ray crystallographic structure of this compound is described and it reveals the presence of an ethanol molecule inside the cavity of the host. Finally, the ability of cryptophane-B to bind xenon in 1,1,2,2-tetrachloroethane-$d_2$ is also studied via hyperpolarized $^{129}$Xe NMR
Document type :
Journal articles
Domain :

Cited literature [42 references]

https://hal-cea.archives-ouvertes.fr/cea-01922217
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Submitted on : Wednesday, November 14, 2018 - 1:33:04 PM
Last modification on : Friday, October 22, 2021 - 2:04:02 PM
Long-term archiving on: : Friday, February 15, 2019 - 2:23:45 PM

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### Citation

Thierry Brotin, Erwann Jeanneau, Patrick Berthault, Estelle Léonce, Delphine Pitrat, et al.. Synthesis of Cryptophane-B. Crystal Structure and Study of its Complex with Xenon.. Journal of Organic Chemistry, American Chemical Society, 2018, 83, pp.14465-14471. ⟨10.1021/acs.joc.8b02246⟩. ⟨cea-01922217⟩

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