, Rajaram Swaminathan asked: Is it possible to observe DNA-protein interactions and enzyme catalysis in deep eutectic solvents? Have such studies been reported? Bern Kohler answered: A variety of enzymes have been shown to retain activity in deep eutectic solvents and catalyze synthetically valuable reactions, pp.1-6
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, Reji Varghese asked: Is the cationic component of the eutectic mixture bound to the phosphate backbone of DNA? Could this be a possible way to dissolve DNA in organic solvents? Bern Kohler responded: One study has suggested that choline ions have a high affinity for the minor groove of AT-rich DNAs where they form hydrogen bonds. 1 In my opinion
, Conflicts of interest, vol.118, pp.379-389, 2014.
Schertler is a co-founder of the leadXpro and InterAx biotechnology companies ,