Soft 3D retinal implants with diamond electrode a way for focal stimulation

Lionel Rousseau (1) , Emmanuel Scorsone (2) , Abderrahmane Bendali (3) , Milan Djilas (4) , Hugues Girard (5) , Myline Cottance (6, 7) , Sébastien Joucla (8) , Elisabeth Dubus (3) , Julie Degardin (4) , Blaise Yvert (8) , Gaelle Bazin Lissorgues (1) , Philippe Bergonzo (2) , Serge Picaud (4)

1 ESYCOM - Electronique, Systèmes de communication et Microsystèmes
2 LCD-LIST - Laboratoire Capteurs Diamant
3 Institut de la Vision
4 Inserm U968/CNRS UMR7210/UPMC UM80 - Equipe 14 - Inflammation dans la dégénérescence neuronale et le remodelage vasculaire
5 LIST (CEA) - Laboratoire d'Intégration des Systèmes et des Technologies
6 ESIEE Paris
7 ESIEE - Laboratoire IAAI
8 CNIC - Centre de neurosciences intégratives et cognitives

In neuroprostheses, the focal stimulation of the neuronal tissues is today a real challenge. These questions are particularly important in retinal prostheses to improve the quality of the images mapped onto an electrode array. It has been demonstrated that to achieve a normal vision the future generation of retinal implant must have 600 pixels with a pitch between electrodes around 50 μm. The long term in-vivo stability of electrodes in contact with the tissues remains a general and important challenge. After several days of implantation several histological studies show an inflammatory of the tissue at the interface between the electrode and tissues. Here we proposed a new approach based on retinal implants fabricated from 3D shaped diamond electrodes exhibiting both an improvement of the spatial resolution of the stimulation and a long term bio-inertness.

Keywords: biological tissues; biomedical electrodes; diamond; eye; retinal prostheses; mapped image quality improvement; electrode array; neuronal tissue; neuroprostheses; focal stimulation; 2D shape diamond electrode; soft 3D retinal implant fabrication; vision; prosthetics; bioinertness; spatial resolution; tissue inflammatory; in-vivo electrode stability; image resolution; medical image processing; neurophysiology; 3D structures; Diamond electrodes; Retinal implant

Domains: Engineering Sciences [physics]; Micro and nanotechnologies/Microelectronics; Life Sciences [q-bio]; Neurons and Cognition [q-bio.NC]; Life Sciences [q-bio]; Bioengineering; Biomaterials; Life Sciences [q-bio]; Biotechnology; Life Sciences [q-bio]; Bioengineering; Imaging; Engineering Sciences [physics]; Electromagnetism; Engineering Sciences [physics]; Electronics; Engineering Sciences [physics]; Materials

Lionel Rousseau, Emmanuel Scorsone, Abderrahmane Bendali, Milan Djilas, Hugues Girard, et al.. Soft 3D retinal implants with diamond electrode a way for focal stimulation. 2013 Transducers & Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS & EUROSENSORS XXVII), Jun 2013, Barcelona, Spain. pp.1227-1230, ⟨10.1109/Transducers.2013.6626996⟩. ⟨cea-01887750⟩