Mechanisms of immunomodulation by mammalian and viral decoy receptors: insights from structures

Abstract : Immune responses are regulated by effector cytokines and chemokines that signal through cell surface receptors. Mammalian decoy receptors — which are typically soluble or inactive versions of cell surface receptors or soluble protein modules termed binding proteins — modulate and antagonize signalling by canonical effector–receptor complexes. Viruses have developed a diverse array of molecular decoys to evade host immune responses; these include viral homologues of host cytokines, chemokines and chemokine receptors; variants of host receptors with new functions; and novel decoy receptors that do not have host counterparts. Over the past decade, the number of known mammalian and viral decoy receptors has increased considerably, yet a comprehensive curation of the corresponding structure–mechanism relationships has not been carried out. In this Review, we provide a comprehensive resource on this topic with a view to better understanding the roles and evolutionary relationships of mammalian and viral decoy receptors, and the opportunities for leveraging their therapeutic potential.
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Submitted on : Thursday, October 4, 2018 - 10:14:31 AM
Last modification on : Tuesday, August 13, 2019 - 10:56:18 AM

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Jan Felix, Savvas Savvides. Mechanisms of immunomodulation by mammalian and viral decoy receptors: insights from structures. Nature Reviews Immunology, Nature Publishing Group, 2017, 17 (2), pp.112 - 129. ⟨10.1038/nri.2016.134⟩. ⟨cea-01887432⟩

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