Selective layer-free blood serum ionogram based on ion-specific interactions with a nanotransistor

Abstract : Despite being ubiquitous in the fields of chemistry and biology, the ion-specific effects of electrolytes pose major challenges for researchers. A lack of understanding about ion-specific surface interactions has hampered the development and application of materials for (bio-)chemical sensor applications. Here, we show that scaling a silicon nanotransistor sensor down to ~25 nm provides a unique opportunity to understand and exploit ion-specific surface interactions, yielding a surface that is highly sensitive to cations and inert to pH. The unprecedented sensitivity of these devices to Na$^+$ and divalent ions can be attributed to an overscreening effect via molecular dynamics. The surface potential of multi-ion solutions is well described by the sum of the electrochemical potentials of each cation, enabling selective measurements of a target ion concentration without requiring a selective organic layer. We use these features to construct a blood serum ionogram for Na$^+$, K$^+$, Ca$^{2+}$ and Mg$^{2+}$, in an important step towards the development of a versatile, durable and mobile chemical or blood diagnostic tool.
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https://hal-cea.archives-ouvertes.fr/cea-01883606
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Submitted on : Friday, September 28, 2018 - 1:55:33 PM
Last modification on : Tuesday, November 19, 2019 - 2:08:10 PM

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R. Sivakumarasamy, R. Hartkamp, B. Siboulet, Jean-François Dufrêche, K. Nishiguchi, et al.. Selective layer-free blood serum ionogram based on ion-specific interactions with a nanotransistor. Nature Materials, Nature Publishing Group, 2018, 17 (5), pp.464 - 470. ⟨10.1038/s41563-017-0016-y⟩. ⟨cea-01883606⟩

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