Selective layer-free blood serum ionogram based on ion-specific interactions with a nanotransistor - Archive ouverte HAL Access content directly
Journal Articles Nature Materials Year : 2018

Selective layer-free blood serum ionogram based on ion-specific interactions with a nanotransistor

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Abstract

Despite being ubiquitous in the fields of chemistry and biology, the ion-specific effects of electrolytes pose major challenges for researchers. A lack of understanding about ion-specific surface interactions has hampered the development and application of materials for (bio-)chemical sensor applications. Here, we show that scaling a silicon nanotransistor sensor down to ~25 nm provides a unique opportunity to understand and exploit ion-specific surface interactions, yielding a surface that is highly sensitive to cations and inert to pH. The unprecedented sensitivity of these devices to Na$^+$ and divalent ions can be attributed to an overscreening effect via molecular dynamics. The surface potential of multi-ion solutions is well described by the sum of the electrochemical potentials of each cation, enabling selective measurements of a target ion concentration without requiring a selective organic layer. We use these features to construct a blood serum ionogram for Na$^+$, K$^+$, Ca$^{2+}$ and Mg$^{2+}$, in an important step towards the development of a versatile, durable and mobile chemical or blood diagnostic tool.

Dates and versions

cea-01883606 , version 1 (28-09-2018)

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Cite

R. Sivakumarasamy, R. Hartkamp, Bertrand Siboulet, Jean-François Dufrêche, K. Nishiguchi, et al.. Selective layer-free blood serum ionogram based on ion-specific interactions with a nanotransistor. Nature Materials, 2018, 17 (5), pp.464 - 470. ⟨10.1038/s41563-017-0016-y⟩. ⟨cea-01883606⟩
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