TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons

Layal Maatouk (1) , Anne-Claire Compagnion (1) , Maria-Angeles Carrillo-De Sauvage (2, 3) , Alexis-Pierre Bemelmans (2, 3) , Sabrina Leclere-Turbant (4, 5) , Vincent Cirotteau (1) , Mira Tohmé (6) , Allen Beke (1) , Michael Trichet (7) , Virginie Bazin (7) , Bobby Trawick (8) , Richard Ransohoff (9) , Francois Tronche (1) , Bénédicte Manoury (6) , Sheela Vyas (1)

1 NPS - Neuroscience Paris Seine
2 JACOB - Institut de Biologie François JACOB
3 MIRCEN - Service MIRCEN
4 CHU Pitié-Salpêtrière [AP-HP]
5 NeurATRIS - IHU-A-ICM - Institut de neurosciences translationnelles de Paris
6 INEM - UM 111 (UMR 8253 / U1151) - Institut Necker Enfants-Malades
7 IBPS-ME - Microscopie Electronique [IBPS]
8 Mallinckrodt Pharmaceuticals
9 Third Rock Ventures

Domains: Life Sciences [q-bio]; Bioengineering

Layal Maatouk, Anne-Claire Compagnion, Maria-Angeles Carrillo-De Sauvage, Alexis-Pierre Bemelmans, Sabrina Leclere-Turbant, et al.. TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons. Nature Communications, 2018, 9, pp.2450. ⟨10.1038/s41467-018-04569-y⟩. ⟨cea-01881325⟩