Convergent genomic signatures of domestication in sheep and goats

Florian Alberto 1 Frédéric Boyer 1 Pablo Orozco-Terwengel 2 Ian Streeter 3 Bertrand Servin 4 Pierre de Villemereuil 1 Badr Benjelloun 1 Pablo Librado 5 Filippo Biscarini 6 Licia Colli 7 Mario Barbato 2, 7 Wahid Zamani 8, 1 Adriana Alberti 9, 10 Stefan Engelen 10, 9 Alessandra Stella 6 Stéphane Joost 11 Paolo Ajmone-Marsan 7, 12 Riccardo Negrini 12 Ludovic Orlando 13 Hamid Reza Rezaei 14 Saeid Naderi 1 Laura Clarke 3 Paul Flicek 3 Patrick Wincker 9, 10, 15 Eric Coissac 1 James Kijas 16 Gwenola Tosser-Klopp 4 Abdelkader Chikhi 17 Michael Bruford 2 Pierre Taberlet 1 François Pompanon 1
Abstract : The evolutionary basis of domestication has been a longstanding question and its genetic architecture is becoming more tractable as more domestic species become genome-enabled. Before becoming established worldwide, sheep and goats were domesticated in the fertile crescent 10,500 years before present (YBP) where their wild relatives remain. Here we sequence the genomes of wild Asiatic mouflon and Bezoar ibex in the sheep and goat domestication center and compare their genomes with that of domestics from local, traditional, and improved breeds. Among the genomic regions carrying selective sweeps differentiating domestic breeds from wild populations, which are associated among others to genes involved in nervous system, immunity and productivity traits, 20 are common to Capra and Ovis. The patterns of selection vary between species, suggesting that while common targets of selection related to domestication and improvement exist, different solutions have arisen to achieve similar phenotypic end-points within these closely related livestock species.
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Submitted on : Monday, September 17, 2018 - 4:31:56 PM
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Florian Alberto, Frédéric Boyer, Pablo Orozco-Terwengel, Ian Streeter, Bertrand Servin, et al.. Convergent genomic signatures of domestication in sheep and goats. Nature Communications, Nature Publishing Group, 2018, 9, pp.813. ⟨10.1038/s41467-018-03206-y⟩. ⟨cea-01875703⟩



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