Inductive Coupling and Flow for Increased NMR Sensitivity

Guillaume Carret (1) , Thomas Berthelot (2) , Patrick Berthault (1)

1 LSDRM - Laboratoire Structure et Dynamique par Résonance Magnétique (LCF)
2 LICSEN - Laboratoire Innovation en Chimie des Surfaces et NanoSciences

A device is proposed to enhance the NMR sensitivity of slowly-relaxing nuclei, taking advantage of a controlled solution flow within a microfluidic circuit and micro-sized NMR detection. At the difference of our previous work (Carret at al., Anal. Chem. 2017, 89 (5), 2995–3000), this set-up can be easily installed on any commercial NMR probehead as it uses induction between the commercial antenna and the micro-coil. Such a system leads to a significant gain in sensitivity per time unit for slowly relaxing nuclei while preserving the capabilities of the host probehead.

Keywords: NMR; relaxation; sensitivity; 3D printing; micro-detection

Domains: Material chemistry; Analytical chemistry

Guillaume Carret, Thomas Berthelot, Patrick Berthault. Inductive Coupling and Flow for Increased NMR Sensitivity. Analytical Chemistry, 2018, 90, pp.11169-11173. ⟨10.1021/acs.analchem.8b01775⟩. ⟨cea-01872249⟩