, Matthias Riemenschneider, vol.77, p.83

, Veikko Salomaa 154, Michel D. Ferrari 129 , Andrea C. Belin 132 , Arn M. J. M. van den Maagdenberg, vol.153, p.242, 2011.

T. Ceresa and F. , , vol.435

, 438 Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital

, 441 Human Genetics Branch, National Institute of Mental Health, National Institutes of Health

, Advanced Interventions Service, NHS Tayside

, Neuroimaging, Cognition and Genomics, vol.452

, 460 Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, vol.469

, 559 Child and Adolescent Psychiatry Unit (UPIA), Youthdale Treatment Centers, vol.562, p.563

, 569 Reference center for Gilles de la Tourette syndrome, Pitie-Salpetriere Hospital, p.566

G. Essen, 578 Escuela de Ciencias de la Salud, 581 Brain Center Rudolf Magnus, vol.576

, 588 Departments of Medicine and Psychiatry, Boston Healthcare System, vol.586

, 600 Department of Molecular Bases of Human Genetics, Institute of Molecular Genetics, Latvian Biomedical Research and Study Centre, vol.601

C. Centre-for-neuroimaging and . Genomics,

J. B. Martin, The integration of neurology, psychiatry, and neuroscience in the 21st century, Am. J. Psychiatry, vol.159, pp.695-704, 2002.

J. W. Smoller, Disorders and borders: Psychiatric genetics and nosology, Am. J. Med. Genet. B. Neuropsychiatr. Genet, vol.162, pp.559-578, 2013.

T. R. Insel and P. S. Wang, Rethinking mental illness, JAMA, vol.303, pp.1970-1971, 2010.

T. J. Polderman, Meta-analysis of the heritability of human traits based on fifty years of twin studies, Nat. Genet, vol.47, pp.702-709, 2015.

K. S. Kendler, C. A. Prescott, J. Myers, and N. Mc, The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women, Arch. Gen. Psychiatry, vol.60, pp.929-937, 2003.

R. Jensen and L. J. Stovner, Epidemiology and comorbidity of headache, Lancet Neurol, vol.7, pp.354-361, 2008.

J. Nuyen, Comorbidity was associated with neurologic and psychiatric diseases: A general practice-based controlled study, J. Clin. Epidemiol, vol.59, pp.1274-1284, 2006.

R. M. Hirschfeld, Screening for bipolar disorder in the community, J. Clin. Psychiatry, vol.64, pp.53-59, 2003.

A. Pan, Q. Sun, O. I. Okereke, K. M. Rexrode, and F. B. Hu, Depression and risk of stroke morbidity and mortality: A meta-analysis and systematic review, JAMA, vol.306, pp.1241-1249, 2011.

A. Lo-castro and P. Curatolo, Epilepsy associated with autism and attention deficit hyperactivity disorder: Is there a genetic link, Brain Dev, vol.36, pp.185-193, 2014.

E. N. Bertelsen, J. T. Larsen, L. Petersen, J. Christensen, S. Dalsgaard et al., Febrile Seizures, and Subsequent Risk of ADHD, Pediatrics, vol.138, p.20154654, 2016.

C. G. De-kovel, Recurrent microdeletions at 15q11.2 and 16p13.11 predispose to idiopathic generalized epilepsies, Brain, vol.133, pp.23-32, 2010.

T. D. Graves and M. G. Hanna, Neurological channelopathies, Postgrad. Med. J, vol.81, pp.20-32, 2005.

J. Haan, G. M. Terwindt, A. M. Van-den-maagdenberg, A. H. Stam, and M. D. Ferrari, A review of the genetic relation between migraine and epilepsy, Cephalalgia, vol.28, pp.105-113, 2008.

S. Debette, Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection, Nat. Genet, vol.47, pp.78-83, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01253336

S. M. Purcell, Common polygenic variation contributes to risk of schizophrenia and bipolar disorder, Nature, vol.460, pp.748-752, 2009.

, Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs, Nat. Genet, vol.45, pp.984-994, 2013.

J. C. Lambert, Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease, Nat. Genet, vol.45, pp.1452-1458, 2013.

T. W. Mühleisen, Genome-wide association study reveals two new risk loci for bipolar disorder, Nat. Commun, vol.5, p.3339, 2014.

V. Anttila, Genome-wide meta-analysis identifies new susceptibility loci for migraine, Nat. Genet, vol.45, pp.912-917, 2013.

M. A. Nalls, Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease, Nat. Genet, vol.46, pp.989-993, 2014.

, Biological insights from 108 schizophrenia-associated genetic loci, Nature, vol.511, pp.421-427, 2014.

N. Solovieff, C. Cotsapas, P. H. Lee, S. M. Purcell, and J. W. Smoller, Pleiotropy in complex traits: Challenges and strategies, Nat. Rev. Genet, vol.14, pp.483-495, 2013.

B. Bulik-sullivan, An atlas of genetic correlations across human diseases and traits, Nat. Genet, vol.47, pp.1236-1241, 2015.

, See materials and methods and other supplementary materials

H. K. Finucane, Partitioning heritability by functional annotation using genome-wide association summary statistics, Nat. Genet, vol.47, pp.1228-1235, 2015.

M. H. De-moor, Meta-analysis of genome-wide association studies for personality, Mol. Psychiatry, vol.17, pp.337-349, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00601880

R. A. Power and M. Pluess, Heritability estimates of the Big Five personality traits based on common genetic variants, Transl. Psychiatry, vol.5, p.604, 2015.

C. M. Haworth, The heritability of general cognitive ability increases linearly from childhood to young adulthood, Mol. Psychiatry, vol.15, pp.1112-1120, 2010.

I. J. Deary, Genetic contributions to stability and change in intelligence from childhood to old age, Nature, vol.482, pp.212-215, 2012.

S. De-rubeis, Synaptic, transcriptional and chromatin genes disrupted in autism, Nature, vol.515, pp.209-215, 2014.

S. H. Lee, Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis, Hum. Mol. Genet, vol.22, pp.832-841, 2013.

A. Okbay, Genome-wide association study identifies 74 loci associated with educational attainment, Nature, vol.533, pp.539-542, 2016.
URL : https://hal.archives-ouvertes.fr/hal-02017372

D. J. Smith, Genome-wide analysis of over 106 000 individuals identifies 9 neuroticismassociated loci, Mol. Psychiatry, vol.21, pp.749-757, 2016.

P. F. Buckley, B. J. Miller, D. S. Lehrer, and D. J. Castle, Psychiatric comorbidities and schizophrenia, Schizophr. Bull, vol.35, pp.383-402, 2009.

C. G. Lyketsos, Mental and behavioral disturbances in dementia: Findings from the Cache County Study on Memory in Aging, Am. J. Psychiatry, vol.157, pp.708-714, 2000.

, Author manuscript; available in PMC, Science, 2018.

R. Kendell and A. Jablensky, Distinguishing between the validity and utility of psychiatric diagnoses, Am. J. Psychiatry, vol.160, pp.4-12, 2003.

A. S. Cristino, Neurodevelopmental and neuropsychiatric disorders represent an interconnected molecular system, Mol. Psychiatry, vol.19, pp.294-301, 2014.

D. A. Regier, Limitations of diagnostic criteria and assessment instruments for mental disorders. Implications for research and policy, Arch. Gen. Psychiatry, vol.55, pp.109-115, 1998.

T. M. Laursen, E. Agerbo, and C. B. Pedersen, Bipolar disorder, schizoaffective disorder, and schizophrenia overlap: A new comorbidity index, J. Clin. Psychiatry, vol.70, pp.1432-1438, 2009.

N. R. Wray, S. H. Lee, and K. S. Kendler, Impact of diagnostic misclassification on estimation of genetic correlations using genome-wide genotypes, Eur. J. Hum. Genet, vol.20, pp.668-674, 2012.

E. G. Willcutt, A. E. Doyle, J. T. Nigg, S. V. Faraone, and B. F. Pennington, Validity of the executive function theory of attention-deficit/hyperactivity disorder: A meta-analytic review, Biol. Psychiatry, vol.57, pp.1336-1346, 2005.

J. T. Spector, Migraine headache and ischemic stroke risk: An updated meta-analysis, Am. J. Med, vol.123, pp.612-624, 2010.

O. B. Fasmer, A. Halmøy, K. J. Oedegaard, and J. Haavik, Adult attention deficit hyperactivity disorder is associated with migraine headaches, Eur. Arch. Psychiatry Clin. Neurosci, vol.261, p.21394551, 2011.
DOI : 10.1007/s00406-011-0203-9
URL : https://link.springer.com/content/pdf/10.1007%2Fs00406-011-0203-9.pdf

N. Breslau, R. B. Lipton, W. F. Stewart, L. R. Schultz, and K. M. Welch, Comorbidity of migraine and depression: Investigating potential etiology and prognosis, Neurology, vol.60, pp.1308-1312, 2003.

K. R. Merikangas, J. Angst, and H. Isler, Migraine and psychopathology. Results of the Zurich cohort study of young adults, Arch. Gen. Psychiatry, vol.47, pp.849-853, 1990.
DOI : 10.1001/archpsyc.1990.01810210057008

G. Barabas, W. S. Matthews, and M. Ferrari, Tourette's syndrome and migraine, Arch. Neurol, vol.41, pp.871-872, 1984.

R. S. Mcintyre, The prevalence and impact of migraine headache in bipolar disorder: Results from the Canadian Community Health Survey, Headache, vol.46, pp.973-982, 2006.

M. T. Heneka, Neuroinflammation in Alzheimer's disease, Lancet Neurol, vol.14, pp.388-405, 2015.

E. C. Hirsch and S. Hunot, Neuroinflammation in Parkinson's disease: A target for neuroprotection?, Lancet Neurol, vol.8, pp.382-397, 2009.

E. M. Frohman, M. K. Racke, and C. S. Raine, Multiple sclerosis-the plaque and its pathogenesis, N. Engl. J. Med, vol.354, pp.942-955, 2006.

C. Waeber and M. A. Moskowitz, Migraine as an inflammatory disorder, Neurology, vol.64, issue.2, pp.9-15, 2005.
DOI : 10.1212/wnl.64.10_suppl_2.s9

J. Steiner, Increased prevalence of diverse N-methyl-D-aspartate glutamate receptor antibodies in patients with an initial diagnosis of schizophrenia: Specific relevance of IgG NR1a antibodies for distinction from N-methyl-D-aspartate glutamate receptor encephalitis, JAMA Psychiatry, vol.70, pp.271-278, 2013.

L. Jones, Convergent genetic and expression data implicate immunity in Alzheimer's disease, Alzheimers Dement, vol.11, pp.658-671, 2015.

M. De-moor, Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder, JAMA Psychiatry, vol.72, pp.642-650, 2015.

K. S. Kendler, M. Gatz, C. O. Gardner, and N. L. Pedersen, Personality and major depression: A Swedish longitudinal, population-based twin study, Arch. Gen. Psychiatry, vol.63, pp.1113-1120, 2006.

R. E. Ørstavik, K. S. Kendler, N. Czajkowski, K. Tambs, and T. Reichborn-kjennerud, The relationship between depressive personality disorder and major depressive disorder: A population-based twin study, Am. J. Psychiatry, vol.164, pp.1866-1872, 2007.

H. Hemingway and M. Marmot, Evidence based cardiology: Psychosocial factors in the aetiology and prognosis of coronary heart disease. Systematic review of prospective cohort studies, BMJ, vol.318, pp.1460-1467, 1999.

F. J. Mcclernon and S. H. Kollins, ADHD and smoking: From genes to brain to behavior, Ann. N. Y. Acad. Sci, vol.1141, pp.131-147, 2008.

T. Korhonen, Externalizing behaviors and cigarette smoking as predictors for use of illicit drugs: A longitudinal study among Finnish adolescent twins, Twin Res. Hum. Genet, vol.13, pp.550-558, 2010.

D. A. Snowdon, Linguistic ability in early life and cognitive function and Alzheimer's disease in late life. Findings from the Nun Study, JAMA, vol.275, pp.528-532, 1996.

S. Cortese, Association Between ADHD and Obesity: A Systematic Review and MetaAnalysis, Am. J. Psychiatry, vol.173, pp.34-43, 2016.

A. E. Locke, Genetic studies of body mass index yield new insights for obesity biology, Nature, vol.518, pp.197-206, 2015.

L. Mustelin, Long-term outcome in anorexia nervosa in the community, Int. J. Eat. Disord, vol.48, pp.851-859, 2015.

T. Kurth, Prospective study of body mass index and risk of stroke in apparently healthy women, Circulation, vol.111, pp.1992-1998, 2005.

S. R. Korndörfer, Long-term survival of patients with anorexia nervosa: A population-based study in Rochester, Minn. Mayo Clin. Proc, vol.78, pp.278-284, 2003.

P. F. Sullivan, Discrepant results regarding long-term survival of patients with anorexia nervosa?, Mayo Clin. Proc, vol.78, p.34, 2003.

, Author manuscript; available in PMC, Science, 2018.

, References are listed in table S1 and data availability in table S13 PGC-ADD2, Psychiatric Genomics Consortium (PGC) Attention Deficit Disorder Working Group; PGC-ED, PGC Eating Disorder Working Group; ANGST, Anxiety Neuro Genetics STudy; PGC-AUT, PGC Autism Spectrum Disorder Working Group; PGC-BIP2, PGC Bipolar Disorder Working Group; PGC-MDD2, PGC Major Depressive Disorder Working Group; PGC-OCDTS, PGC Obsessive Compulsive Disorder and Tourette Syndrome Working Group, PGC Posttraumatic Stress Disorder Working Group

. Ilae, International League Against Epilepsy Consortium on Complex Epilepsies

, ISGC, International Stroke Genetics Consortium

, METASTROKE, a consortium of the ISGC

, IHGC, International; Headache Genetics Consortium

, IMSGC, International Multiple Sclerosis Genetics Consortium

, International Parkinson's Disease Genomics Consortium. W indicates same as above, IPDGC