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Journal articles

Analysis of shared heritability in common disorders of the brain

Verneri Anttila 1 Brenda Sullivan 1 Hilary Finucane 2 Walter Walters 1 Jose Bras 3 Laramie Duncan 1 Valentina Price 4 Guido Falcone 1 Padhraig Gormley 1 Rainer Malik 5 Pat Patsopoulos 2 Stephan Ripke 1 Wei Wei 6 Dongmei Yu 2 Phil L Lee 2 Patrick Turley 1 Benjamin Grenier-Boley 7 Vincent Chouraki 7 Yoichiro Kamatani 8 Claudine Berr 9 Luc Letenneur 10, 11 Didier Hannequin 12 Philip Amouyel 7 Anne Boland 13 Jean-François Deleuze 13 Emmanuelle Duron 14 N. Vardarajan Chris Reitz 15 Alison Goate 16 Matthew Huentelman M. Ilyas Kamboh 17 Lars Larson 18 Ekaterina Rogaeva 19 Peter St George-Hyslop 19 Hakon Hakonarson 20 Walter Kukull Lindsay Li Lisa Li Thomas Thomas F. Yesim Demirci 17 Eli Head 21 Chris Hulette 22 Gregory Jicha 23 John Kauwe 24 Jeffrey Kaye 25 James Leverenz 26 Allan Levey 27 Andrew Li 28 Vernon Pankratz 29 Wayne Poon 30 Joseph Quinn 31 Andrew Saykin 32 Lon Lo 33 Amanda Smit 34 Joshua So 35 Robert Stern 36 Vivianna van Deerlin 37 Linda Li 21 Denise Harold 38 Giancarlo Russo 39 David C. Rubinsztein 40 Anthony Bayer 41 Magda Tsolaki 42 Petra Proitsi 43 Nick Fox 44 Harald Hampel 45 Michael Owen 46 Simon Sim 47 Peter Passmore 48 Kevin Morgan 49 Mark Markus 50 Jonathan Schott 51, 44 Martin Kauffmann Michel Lupton 52 Per Hoffmann 50 Johannes Kornhuber 53 Brian Lawlor 54 Andrew Mcquillin 55 Ammar Al-Chalabi 43 Joshua Bis 56 Agustin Ruiz Mercè Boada Sudha Seshadri 57 Alexa Beiser 58 Kenneth Rice 18 Sven van Der Lee 59 Philip de Jager 60 Dan Geschwind 61 Matthias Riemenschneider 62 Helle Riedel-Heller 63 Jerome Rotter 64 Gerhard Ran 65 Bradley T. Hyman 66 Carlos Cruchaga 67 Montserrat Alegret Bendik Winsvold 68 Priit Palta 69 Kai-How Farh 2 Ester Cuenca-Leon 1 Nicholas Furlotte 70 Tobias Kurth 71 Lannie Li 72 Gisela Terwindt 73 Tobias Freilinger 74 Carol Ran 75 Scott Scott 52 Guntram Borck 76 Hieab H.H. Adams 59 Terho Lehtimaki 77 Juho Wedenoja 78 Julie Buring 79 Maria Hrafnsdottir 80 Jan Hottenga 72 Brenda Penninx 81 Ville Artto Mari Kaunisto 69 Salli Vepsäläinen Nicholas M Martin 52 Grant W. Montgomery 52 Mitja Kurki 1 Eija Hämäläinen 69 Hailiang Huang 1 Jie Huang 82 Cynthia Sandor 83 Caleb Webb 83 Bertram Müller-Myhsok 84 Stefan Schreiber 85, 86 Veikko Salomaa 87 Eli Lo 88 Hartmut Göbel Alfons Macaya 89 Pat Pozo-Rosich 90 Jaakko Kaprio 87, 69 Andres Metspalu 91 Chris Kubisch 92 Michel Ferrari 73 Andrea Belin 75 Arn M.J.M. van den Maagdenberg 93 John Zwart 68 Dorret I. Boomsma 94 Nicholas Eriksson 70 Ole Olesen 95 Dan Chasman 79 Dale Nyholt 96 Richard Anney 97, 46 Andreja Avbersek 98 Larry Bau 99 Samuel F. Berkovic 100 Jonathan Bradfield Russell Buono 101 Claudia Catarino 98 Patrick Cossette 102 Peter de Jonghe 103 Chantal Depondt 104 Dennis Dlugos 20 Jacqueline French 105 Helle Hjalgrim Jennifer Jamnadas-Khoda 98 Reetta Kälviäinen 106 Wolfram Kunz 107 Holger Lerche 108 Costin Leu 109 Dick Li 110 Warren Lo 111 Dan Lowenstein 112 Mark Mccormack 113 Rikke Møller 114 Anne Molloy 115 Ping-Wing Ng 116 Oliver Oliver 100 Michael Privitera 117 Rodney Radtke 22 Ann-Kathrin Ruppert 118 Steve Schachter 66 Chris Schankin 119 Ingrid E. Scheffer 100 Susan Schoch 107 Sanjay Sisodiya 98 Philip Smit 120 Michael Sperling 121 Pasquale Striano Rainer Surges 107 Frank Visscher Chris Whelan 113 Federico Zara Erin Heinzen 60 Anthony Marson 122 Felicitas Becker 123 Hans Stroink Fritz Zimprich 124 Thomas Gasser 123 Raphael Gibbs 125 Peter Heutink 126 Matias Martinez 127 Huw Morris 98 Manu Sharma 123 Mina Ryten 98 Kin Mok 98 Sara Pulit 110 Steve Bevan 128 Eli Holliday 129 John Attia 129 Thomas Battey 1 Giorgio Boncoraglio 130 Vincent Thijs 100 Wei Chen 131 Braxton Mitchell 132 Peter M Rothwell 133 Pankaj Sharma 134 Cathie Cath 135 Astrid M. Vicente 136 Chris Kourkoulis 2 Joana Pera 137 Miriam Mir 2 Vesna Boraska Perica 138 Laura Thornton 139 Laura Huckins 140 N. William Rayner 133 Cathryn Cath Mònica Gratacòs 141 Filip Rybakowski Anna Keski-Rahkonen 78 Anu Raevuori 78 James Hudson 142 Ted Reichborn-Kjennerud 143 Palmiero Monteleone 144 Andreas Karwautz 124 Katrin Männik 91 Jessica Baker 139 Julie O’toole Sara Trace 139 Oliver Davis 145 Sietske Helder Stefan Ehrlich 146 Beate Herpertz-Dahlmann 147 Dan Danner 148 Annemarie van Elburg 148 Maurizio Clementi 149 Monica Forzan Eli Docampo 150 Jolanta Li 151 Joanna Hauser Alfonso Tortorella 152 Mario Maj 153 Fragiskos Gonidakis 154 Konstantinos Tziouvas Hana Papezova 155 Zeynep Yilmaz 139 Gudrun Wagner 156 Sarah Wood 157 Stefan Herms 50 Antonio Julià 90 Raquel Rabionet 141 Dan Dick 158 Samuli Ripatti 69 Andreas Andreassen 159 Thomas Espeseth 159 Astri Lundervold 160 Vidar Steen 160 Dalila Pinto 140 Stephen W. Scherer 161 Harald Aschauer Alexandra Schosser 46, 124 Lars Alfredsson 75 Leonid Padyukov 75 Katherine Halmi 162 James Brian Alexander Mitchell 163 Michael Strober 61 Andrew Bergen 164 Walter Kaye 165 Jin Peng Szatkiewicz 139 Bru Cormand 166 Josep Antoni Ramos 90 Cristina Sánchez-Mora 90 Marta Ribasés 167 Miguel Miguel 89 Amaia Hervás 168 Maria Arranz Jan Haavik 160 Tetyana Zayats 160 Stefan Johansson 169 Nigel Williams 4 Eli Elia 170 Astrid Dempfle 171 Aribert Rothenberger 172 Jonna Kuntsi 173 Robert D. Oades 84 Tobias Banaschewski 174 Barbara Franke 175 Jan Buitelaar 175 Alejandro Arias Vasquez 175 Alysa E. Doyle 1 Andreas Reif 176 Peter Lesch 177 Chris Freitag 176 Olga Rivero Haukur Palmason 80 Marcel Romanos Kate Langley 178 Marcella Rietschel 174 Stephanie Witt 174 Soeren So 179 Anders D. Børglum 179 Irwin Waldman 180 Beth Wilmot 25 Nikolas Molly 181 Claiton H.D. Bau 182 Jennifer Crosbie 183 Russell Schachar 183 Sandra K. Loo 184 James J. Mcgough 61 Eugenio Grevet 185 Sarah M Medland 52 Robin Robinson 1 Wei Weiss 112 Elena Bacchelli 186 Anthony J. Bailey 187 Vanessa Bal 112 Agatino Battaglia 188 Catalina Betancur 189 Patrick F. Bolton 173 Rita M. Cantor 61 Pat So Gerald Dawson 190 Silvia de Rubeis 140 Frederico Duque 191 Andrew Green 192, 193 Sabine M. Klauck 194 Marion Leboyer 195 Pat Levitt 196 Elena Maestrini 186 Shrikant M. Mane 197 Dan De-Luca 198 Jeremy R. Parr 199 Regina Regan 192 Abraham Reichenberg 140 Sven Sandin 200 Jacob Vorstman 183 Thomas H. Wassink 181 Ellen M. Wijsman 201 Edwin H. Cook 202 Susan L. Santangelo 203 Richard Delorme 204 Bernadette Rogé 205 Tiago R. Magalhaes 192 Dan E. Arking 206 Thomas Schulze 207 Robert C. Thompson 208 Jana Strohmaier 209 Matthew Matthews 210 Ingrid Melle 159 Derek Morris 211 Douglas Blackwood 135 Andrew Mcintosh 135 Sarah E. Bergen 75 Martin Schall 75 Stéphane Jamain 195 Anna Maaser 107 Sascha Fischer 212 Céline Reinbold 212 Janice Fullerton 213 Maria Grigoroiu-Serbanescu José Guzman-Parra Fermin Mayoral Peter R. Schofield 213 Sven Cichon 212 Thomas Mühleisen 214 Franziska Degenhardt 50 Johannes Schumacher 50 Michael Bauer 146 Philip B. Mitchell 215 Elliot S. Gershon 216 John P. Rice 217 James B. Potash 218 Peter P. Zandi 219 Nick Craddock 46 I. Nicol Ferrier 199 Martin Alda 220 Guy A. Rouleau 221 Gustavo Turecki 222 Roel Ophoff 184 Carlos N. Pato 223 Adebayo Anjorin 55 Eli Stahl 140 Mark Leber 224 Piotr M. Czerski Howard J. Edenberg 32 Cristiana Cruceanu 222 Ian R. Jones 46 Dan Posthuma 94 Till F.M. Andlauer 84 Andreas Forstner 107 Fabian Streit 174 Bernhard T. Baune 225 Tracy Air 225 Grant Sinnamon 226 Naomi R. Wray 227 Donald J. Macintyre 135 David Porteous 135 Georg Homuth 228 Margarita Rivera 46 Jakob Grove 179 Chris Middeldorp 229 Ian Hickie 230 Michele Pergadia 67 Divya Mehta 231 Johannes Smit 81 Rick Jansen 81 Eco de Geus 72 Erin Dunn 1 Qingqin Li Matthias Nauck 228 Robert Schoevers 232 Aartjan Tf Beekman 81 James Knowles 223 Alexander Viktorin 75 Paul Arnold 233 Cathy Cath 234 Gabriel Bedoya-Berrio 235 O. Joseph Bienvenu 206 Helena Brentani 236 Chris Burton 183 Beatriz Camarena Carol Cappi 236 Dan Cath 232 Maria Cavallini 237 Dan Cusi Sabrina Darrow 112 Damiaan Denys 238 Eske Derks 52 Andrea Dietrich 239 Thomas Fernandez 240 Martijn Figee 241 Nelson B. Freimer 184 Gloria Gerber 1 Marco Grados 218 Erica Greenberg 1 Gregory Hanna 208 Andreas Hartmann 242 Matthew Hirschtritt 112 Pieter Hoekstra 232 Alden Huang 184 Chaim Huyser 241 Cornelia Illmann 1 Michael Jenike 243 Samuel Kuperman 181 Bennett L. Leventhal 112 Chris Lochner 244 Gholson Lyon 245 Fabio Macciardi 246 Marcos Madruga-Garrido 247 Irene Malaty 248 Athanasios Maras Lauren Mcgrath 249 Eurípedes Miguel 236 Pablo Mir 247 Gerald Nestadt 206 Humberto Nicolini Michael S. Okun 248 Andrew Pakstis 240 Peristera Paschou 250 John Piacentini 61 Chris Pittenger 240 Kerstin Plessen 251 Vasily Ramensky 252 Eliana Ramos 61 Victor Reus 112 Margaret Richter 253 Mark Riddle 206 Robert Robertson 55 Veit Roessner 146 Maria Rosário 254 Jack Samuels 218 Paul Sandor 161 Dan J Stein 244 Fotis Tsetsos 255 Filip van Nieuwerburgh 256 Sarah Weatherall 1 Jens Wendland Tomasz Wolanczyk 257 Yulia Worbe 258 Gwyneth Zai 161 Fernando S. Goes 218 Nicole Mclaughlin 198 Paul Nestadt 218 Hans-Jörgen Grabe 228 Chris Depienne 259 Anuar Konkashbaev 260 Nuria Lanzagorta Ana Valencia-Duarte Elvira Bramon 55 Nancy G. Buccola Wiepke Cahn 110 Murray Murray 129 Siow Chong 261 David Cohen 262 Benedicto Crespo-Facorro 263 James Crowley 139 David Davidson 264 Lynn Delisi 243 Timothy Dinan 265 Gary Donohoe 211 Elodie Drapeau 140 Jubao Duan 266 Lieuwe Haan 241 David Hougaard 267 Sena Karachanak-Yankova 268 Andrey Khrunin 269 Janis Klovins 270 Vaidutis Kučinskas 271 Jim Lee Chee Keong 272 Svetlana Limborska 269 Carmel Loughland 129 Jouko Lönnqvist 87 Brion Maher 219 Manuel Mattheisen 179 Colm Mcdonald 273 Kieran Murphy 113 Robin Murray 173 Igor Nenadic 274 Jim van Os 110 Chris Pantelis 100 Michele T. Pato 223 Tracey Petryshen 2 Digby J. Quested 275 Panos Roussos 140 Alan Sanders 216 Ulrich Schall 276 Sibylle Schwab 277 Kang Sim 261 Hon-Cheong So 278 Elisabeth Stögmann 124 Mythily Subramaniam 261 Draga Toncheva 268 John Waddington 113 James Walters 46 Mark Weiser 264 Wei Cheng 139 Robert C. Cloninger 67 David Curtis 55 Pablo V. Gejman 216 Frans Henskens 129 Morten Mattingsdal 159 Sang-Yun Oh 279 Rodney Scott 129 Bradley Webb 158 Gerome Breen 173 Claire Churchhouse 1 Cynthia Bulik 139 Mark J. Daly 1 Martin Dichgans 5 Stephen V. Faraone 223 Rita Guerreiro 3 Peter Holmans 4 Kenneth Kendler 158 Bobby Koeleman 110 Carol Mathews 248 Alkes Price 2 Jeremiah Scharf 2 Pamela Sklar 140 Julie Williams 4 
1 Massachusetts General Hospital [Boston]
2 BROAD INSTITUTE - Broad Institute of MIT and Harvard
3 UK DRI - UK Dementia Research Institute
4 School of Psychology [Cardiff University]
5 ISD - Institute for Stroke and Dementia Research
6 NJIT - New Jersey Institute of Technology [Newark]
7 RID-AGE - Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167
8 RIKEN IMS - RIKEN Center for Integrative Medical Sciences [Yokohama]
9 PSNREC - Neuropsychiatrie : recherche épidémiologique et clinique
10 LBMA - Laboratoire de Biotechnologie et Microbiologie Appliquée
11 BPH - Bordeaux population health
12 Service de neurologie [Rouen]
13 JACOB - Institut de Biologie François JACOB
14 Gériatrie générale et aigüe [Paris]
15 Columbia University [New York]
16 Dpt of Neuroscience [New York]
17 PITT - University of Pittsburgh
18 University of Washington [Seattle]
19 Tanz Center Research in Neurodegenerative Diseases [Toronto]
20 CHOP - Children’s Hospital of Philadelphia
21 University of Kentucky
22 School of medicine
23 College of medicine
24 BYU - Brigham Young University
25 OHSU - Oregon Health and Science University [Portland]
26 Cleveland Clinic
27 Department of Neurology
28 Medical School
29 Health sciences center
30 Institute for Memory Impairments and Neurological Disorders [Irvine]
31 Department of Neurology
32 IUPUI - Indiana University - Purdue University Indianapolis
33 Keck School of Medicine [Los Angeles]
34 USF - University of South Florida [Tampa]
35 University of Utah School of Medicine [Salt Lake City]
36 BUSM - Boston University School of Medicine
37 Perelman School of Medicine
38 DCU - Dublin City University [Dublin]
39 Functional Genomics Center Zurich
40 CIMR - Cambridge Institute for Medical Research
41 Cardiff University
42 Aristotle University of Thessaloniki
43 Maurice Wohl Clinical Neuroscience Institut
44 DRC - Dementia Research Centre [London]
45 GRC 21 APM - Alzheimer Precision Medicine [CHU Pitié-Salpétriêre]
46 MRC Centre for Neuropsychiatric Genetics and Genomics
47 MRC Prion Unit [London]
48 QUB - Queen's University [Belfast]
49 School of Life Sciences
50 Rheinische Friedrich-Wilhelms-Universität Bonn
51 CRCM - Centre de Recherche en Cancérologie de Marseille
52 QIMR Berghofer Medical Research Institute
53 FAU - Friedrich-Alexander Universität Erlangen-Nürnberg
54 School of Medicine [Dublin]
55 UCL - University College of London [London]
56 Department of Medicine
57 University of Texas Health Science Center
58 School of Public Health [Boston]
59 Erasmus MC - Erasmus University Medical Center [Rotterdam]
60 CUMC - Columbia University Medical Center
61 David Geffen School of Medicine [Los Angeles]
62 Saarland University [Saarbrücken]
63 Universität Leipzig [Leipzig]
64 School of Medicine [Los Angeles]
65 JKU - Johannes Kepler University Linz [Linz]
66 Department of Neurology [Boston]
67 School of Medecine
68 Oslo University Hospital [Oslo]
69 FIMM - Institute for Molecular Medicine Finland [Helsinki]
70 23andMe Inc.
71 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
72 Department of Biological Psychology [Amsterdam]
73 Leiden University Medical Center (LUMC)
74 University-Hospital Munich-Großhadern [München]
75 Karolinska Institutet [Stockholm]
76 Universität Ulm - Ulm University [Ulm, Allemagne]
77 Faculty of Medicine and Life Sciences [Tampere]
78 Helsingin yliopisto = Helsingfors universitet = University of Helsinki
79 BWH - Brigham & Women’s Hospital [Boston]
80 Landspitali National University Hospital of Iceland
81 VU University Medical Center [Amsterdam]
82 BVARI - Boston VA Research Institute
83 Department of Physiology, Anatomy and Genetics [Oxford]
84 Max Planck Institute of Psychiatry
85 CAU - Christian-Albrechts-Universität zu Kiel
86 Institute of Clinical Molecular Biology
87 National Institute for Health and Welfare [Helsinki]
88 Harvard T.H. Chan School of Public Health
89 UAB - Universitat Autònoma de Barcelona
90 Vall d'Hebron University Hospital [Barcelona]
91 University of Tartu
92 UKE - Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg]
93 Center for Human and Clinical Genetics
94 VU - Vrije Universiteit Amsterdam [Amsterdam]
95 UCPH - University of Copenhagen = Københavns Universitet
96 IHBI - Institute of Health and Biomedical Innovation
97 Discipline of Psychiatry [Dublin]
98 Institute of Neurology [London]
99 HKU - The University of Hong Kong
100 University of Melbourne
101 CMSRU - Cooper Medical School of Rowan University [Camden]
102 CHUM - Centre Hospitalier de l'Université de Montréal
103 UA - University of Antwerp
104 ULB - Hôpital Erasme [Bruxelles]
105 NYU - New York University School of Medicine
106 University of Eastern Finland
107 UKB - Universitätsklinikum Bonn
108 Hertie Institute for Clinical Brain Research [Tubingen]
109 NIHR Biomedical Research Centre [London]
110 University Medical Center [Utrecht]
111 OSU - Ohio State University [Columbus]
112 UCSF - University of California [San Francisco]
113 RCSI - Royal College of Surgeons in Ireland
114 SDU - University of Southern Denmark
115 Trinity College Dublin
116 UCH - United Christian Hospital [Hong Kong]
117 UC - University of Cincinnati
118 University of Cologne
119 Inselspital Bern
120 University of Wales
121 Jefferson University Hospitals
122 University of Liverpool
123 University of Tübingen
124 Medizinische Universität Wien = Medical University of Vienna
125 NIH - National Institutes of Health [Bethesda]
126 DZNE - German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen
127 IRSD - Institut de Recherche en Santé Digestive
128 University of Lincoln
129 UoN - University of Newcastle [Australia]
130 Fondazione IRCCS Istituto Neurologico "Carlo Besta"
131 University of Virginia [Charlottesville]
132 UMBC - University of Maryland [Baltimore County]
133 University of Oxford [Oxford]
134 RHUL - Royal Holloway [University of London]
135 University of Edinburgh
136 ULISBOA - Universidade de Lisboa = University of Lisbon
137 UJ - Uniwersytet Jagielloński w Krakowie = Jagiellonian University
138 University of Split
139 UNC - University of North Carolina [Chapel Hill]
140 MSSM - Icahn School of Medicine at Mount Sinai [New York]
141 CRG-UPF - Center for Genomic Regulation
142 McLean Hospital [Belmont, Ma.]
143 NIPH - Norwegian Institute of Public Health [Oslo]
144 UNISA - Università degli Studi di Salerno
145 University of Bristol [Bristol]
146 TU Dresden - Technische Universität Dresden = Dresden University of Technology
147 RWTH - Rheinisch-Westfälische Technische Hochschule Aachen
148 Utrecht University [Utrecht]
149 Azienda Ospedaliera di Padova
150 Université de Liège
151 MCMCC - Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology
152 UNIPG - Università degli Studi di Perugia
153 Università degli studi della Campania "Luigi Vanvitelli"
154 NKUA - National and Kapodistrian University of Athens
155 CU - Charles University [Prague]
156 SURFACES
IRCELYON - Institut de recherches sur la catalyse et l'environnement de Lyon
157 Flinders University [Adelaide, Australia]
158 VCU - Virginia Commonwealth University
159 UiO - University of Oslo
160 UiB - University of Bergen
161 University of Toronto
162 Weill Medical College of Cornell University [New York]
163 UND - University of North Dakota [Grand Forks]
164 ORI - Oregon Research Institute
165 UC San Diego - University of California [San Diego]
166 UB - Universitat de Barcelona
167 CIBER-SAM - Centro de Investigación Biomédica en Red Salud Mental [Madrid]
168 Hospital Universitario Mutua de Terrassa
169 School of Computer Science and Communication [Stockholm]
170 Jefferson (Philadelphia University + Thomas Jefferson University)
171 Kiel University
172 UMG - University Medical Center Göttingen
173 King‘s College London
174 Universität Heidelberg [Heidelberg]
175 Radboud University Medical Center [Nijmegen]
176 Universitätsklinikum Frankfurt
177 Maastricht University [Maastricht]
178 Institute of Psychological Medicine and Clinical Neurosciences
179 Aarhus University [Aarhus]
180 Emory University [Atlanta, GA]
181 University of Iowa [Iowa City]
182 UFRGS - Universidade Federal do Rio Grande do Sul [Porto Alegre]
183 SickKids - The Hospital for sick children [Toronto]
184 UCLA - University of California [Los Angeles]
185 HCPA - Hospital de Clínicas de Porto Alegre
186 UNIBO - Alma Mater Studiorum Università di Bologna [Bologna]
187 UBC - University of British Columbia
188 IRCCS Fondazione Stella Maris [Pisa]
189 IBPS - Institut de Biologie Paris Seine
190 Duke University [Durham]
191 Universidade de Coimbra [Coimbra]
192 ACoRD - Academic Centre on Rare Diseases
193 OLCHC - Our Lady's Children's Hospital Crumlin
194 DKFZ - German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg]
195 IMRB - Institut Mondor de Recherche Biomédicale
196 Children’s Hospital Los Angeles [Los Angeles]
197 Yale University [New Haven]
198 Brown University
199 ION - Institute of Neuroscience [Newcastle]
200 MEB - Department of Medical Epidemiology and Biostatistics
201 Division of Medical Genetics [Seattle]
202 UIC - University of Illinois [Chicago]
203 MMCRI - Maine Medical Center Research Institute
204 GHFC (UMR_3571 / U-Pasteur_1) - Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions
205 CERPPS - Centre d’Etudes et de Recherches en Psychopathologie et Psychologie de la Santé
206 Johns Hopkins University School of Medicine [Baltimore]
207 LMU - Ludwig Maximilian University [Munich]
208 University of Michigan [Ann Arbor]
209 Department of Genetic Epidemiology in Psychiatry [Mannhein]
210 University of Dundee
211 NUI Galway - National University of Ireland [Galway]
212 University Hospital Basel [Basel]
213 NeuRA - Neuroscience Research Australia
214 Forschungszentrum Jülich GmbH | Centre de recherche de Juliers
215 UNSW Faculty of Medicine [Sydney]
216 University of Chicago
217 WUSTL - Washington University in Saint Louis
218 JHU - Johns Hopkins University
219 Johns Hopkins Bloomberg School of Public Health [Baltimore]
220 Dalhousie University [Halifax]
221 Montreal Neurological Institute and Hospital
222 McGill University = Université McGill [Montréal, Canada]
223 SUNY - State University of New York
224 University Hospital of Cologne [Cologne]
225 University of Adelaide
226 JCU - James Cook University
227 Institute for Molecular Bioscience
228 Greifswald University Hospital
229 University of Queensland [Brisbane]
230 The University of Sydney
231 QUT - Queensland University of Technology [Brisbane]
232 UMCG - University Medical Center Groningen [Groningen]
233 University of Calgary
234 University Health Network
235 Universidad de Antioquia = University of Antioquia [Medellín, Colombia]
236 USP - Universidade de São Paulo
237 Ospedale San Raffaele
238 UvA - University of Amsterdam [Amsterdam]
239 University of Groningen [Groningen]
240 YSM - Yale School of Medicine [New Haven, Connecticut]
241 AMC - Academic Medical Center - Academisch Medisch Centrum [Amsterdam]
242 CHU Pitié-Salpêtrière [AP-HP]
243 HMS - Harvard Medical School [Boston]
244 University of Cape Town
245 CSHL - Cold Spring Harbor Laboratory
246 UCI - University of California [Irvine]
247 Universidad de Sevilla
248 UF - University of Florida [Gainesville]
249 University of Denver
250 Purdue University [West Lafayette]
251 CHUV - Centre Hospitalier Universitaire Vaudois [Lausanne]
252 MIPT - Moscow Institute of Physics and Technology [Moscow]
253 Sunnybrook Health Sciences Centre
254 IFSP - Federal Institute of São Paulo
255 DUTH - Democritus University of Thrace
256 UGENT - Universiteit Gent = Ghent University [Belgium]
257 Medical University of Warsaw - Poland
258 Sorbonne Université - Faculté de Médecine - Département d'Enseignement et de Recherche en Médecine Générale
259 Uniklinik Essen - Universitätsklinikum Essen [Universität Duisburg-Essen]
260 Vanderbilt University Medical Center [Nashville]
261 Institute of Mental Health [Singapore]
262 SPEA - Service de Psychiatrie de l'Enfant et de l'Adolescent [CHU Pitié-Salpêtrière]
263 Universidad de Cantabria [Santander]
264 Tel Aviv University [Tel Aviv]
265 UCC - University College Cork
266 University of Rochester [USA]
267 Statens Serum Institut [Copenhagen]
268 Софийски университет = Sofia University
269 RAS - Russian Academy of Sciences [Moscow]
270 Latvian Biomedical Research and Study Centre [Rīga]
271 Vilnius University [Vilnius]
272 Nanyang Technological University [Singapour]
273 Department of Life Sciences
274 Jena University Hospital [Jena]
275 Oxford University Hospitals NHS Trust
276 Schizophrenia Research Institute [Sydney]
277 Faculty of Science, Medicine and Health [Wollongong]
278 CUHK - City University of Hong Kong [Hong Kong]
279 LBNL - Lawrence Berkeley National Laboratory [Berkeley]
Abstract : Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology.
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PASTEUR | CEA | UNIV-PARIS7 | RIIP | UPEC-UPEM | UNIV-TLSE2 | CNRS | UNIV-AMU | UNIV-LYON1 | INRA | IRCELYON | RIIP_LILLE | IMRB | UPEC | U1061 | COMUE-NORMANDIE | INC-CNRS | USPC | IBPS | BS | UNIV-MONTPELLIER | JACOB | CEA-DRF | UNIV-LILLE | SORBONNE-UNIVERSITE | CRCM | SU-MEDECINE | SU-SCIENCES | UDL | CERPPS | INRAE | UNIV-PARIS | UP-SCIENCES | SU-TI | IRSD | U1219 | UNIV-UT3 | UT3-TOULOUSEINP

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Verneri Anttila, Brenda Sullivan, Hilary Finucane, Walter Walters, Jose Bras, et al.. Analysis of shared heritability in common disorders of the brain. Science, American Association for the Advancement of Science (AAAS), 2018, 360 (6395), eaap8757. ⟨10.1126/science.aap8757⟩. ⟨cea-01870483⟩

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