Radiolysis of phenylalanine in solution with Bragg-Peak energy protons

Abstract : Phenylalanine aqueous solutions were irradiated with Bragg-Peak energy protons (0.6–5.6 MeV). An innovative circulation setup has been developed for the irradiation of these solutions with low-energy protons. Every detectable radiolysis product has been identified and quantified after irradiation. While tyrosines are well-known products of phenylalanine radiolysis, 2,5-dihydroxyphenylalanine and dimers were detected in high quantities, for the first time. The track-yields (G'-values) of all products formed under proton irradiation were determined and compared to those obtained with gamma-rays, and 2,5-dopa and dimers production seems to be specific to accelerated ions. A bi-radical mechanism could explain their higher production with a higher density of energy deposition in the track structure.
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Submitted on : Tuesday, August 7, 2018 - 4:47:41 PM
Last modification on : Thursday, February 7, 2019 - 2:28:25 PM

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N. Ludwig, T. Kusumoto, C. Galindo, P. Peaupardin, S. Pin, et al.. Radiolysis of phenylalanine in solution with Bragg-Peak energy protons. Radiation Measurements, Elsevier, 2018, 116, pp.55 - 59. ⟨10.1016/j.radmeas.2018.07.007⟩. ⟨cea-01855331⟩

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