Investigation of the response variability of ionization chambers for the standard transfer of SIR-Spheres
Résumé
The present paper addresses the calibration of well-type ionization chambers (ICs) used at LNE-LNHB as standard transfer instruments to calibrate hospitals in the case of SIR-Spheres $^{90}$Y resin microspheres (Sirtex, Australia). Developed for interventional oncology, this radiopharmaceutical is directly injected in the liver for cancer treatment via a selective internal radiation therapy.
The present work was carried out in the framework of the European project “Metrology for molecular radiotherapy” (MetroMRT). As commonly performed in radionuclide metrology for radiopharmaceuticals, the objective is to ensure the metrological traceability of SIR-Spheres to hospitals. Preceding studies were focused on primary measurements of SIR-Spheres based on the TDCR (Triple to Double Coincidence Ratio) method, applied after the dissolution of the $^{90}$Y-labeled resin microspheres. As $^{90}$Y is a high-energy β$^-$-emitter, the IC response strongly depends on the transport of electrons in the radioactive solution and surroundings (vial, chamber liners and materials). The variability of the IC-response due to the geometry dependence is investigated by means of measurements and Monte Carlo simulations in the case of a Vinten IC. The aim of the present study was also to propose a reliable uncertainty for ICs calibrations for the standard transfer of SIR-Spheres to hospitals.
Mots clés
MICROSPHERES
metrology
ionizing radiation
SIMULATION METHOD
Radionuclide metrology
RADIONUCLIDE CALIBRATOR
90Y-labeled resin microspheres
NUCLEAR MEDICINE
SIR-Spheres® standardization
Ionization chamber calibration
Monte Carlo
Y-90
simulation
radioactivity
calibration
Ionization chamber
instrumentation
nuclear instrumentation
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