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Tritium labeling of detonation nanodiamonds

Hugues Girard 1 Abdelouahab El-Kharbachi 2 Sébastien Garcia-Argote 2 Tristan Petit 1 Philippe Bergonzo 1 Bernard Rousseau 3, * Jean-Charles Arnault 1, *
* Corresponding author
1 LCD-LIST - Laboratoire Capteurs Diamant
DM2I - Département Métrologie Instrumentation & Information : DRT/LIST/DM2I
2 LMT - Laboratoire de Marquage au Tritium
SCBM - Service de Chimie Bio-Organique et de Marquage : DRF/JOLIOT
Abstract : For the first time, the radioactive labeling of detonation nanodiamonds was efficiently achieved using a tritium microwave plasma. According to our measurements, the total radioactivity reaches 9120 $\pm$ 120 $\mu$Ci mg−1, with 93% of 3H atoms tightly bonded to the surface and up to 7% embedded into the diamond core. Such 3H doping will ensure highly stable radiolabeled nanodiamonds, on which surface functionalization is still allowed. This breakthrough opens the way to biodistribution and pharmacokinetics studies of nanodiamonds, while this approach can be scalable to easily treat bulk quantities of nanodiamonds at low cost.
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Hugues Girard, Abdelouahab El-Kharbachi, Sébastien Garcia-Argote, Tristan Petit, Philippe Bergonzo, et al.. Tritium labeling of detonation nanodiamonds. Chemical Communications, Royal Society of Chemistry, 2014, 50 (22), pp.2916 - 2918. ⟨10.1039/c3cc49653h⟩. ⟨cea-01832109⟩

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