Skip to Main content Skip to Navigation
Journal articles

Concurrent Visualization of Acoustic Radiation Force Displacement and Shear Wave Propagation with 7T MRI

Abstract : Manual palpation is a common and very informative diagnostic tool based on estimation of changes in the stiffness of tissues that result from pathology. In the case of a small lesion or a lesion that is located deep within the body, it is difficult for changes in mechanical properties of tissue to be detected or evaluated via palpation. Furthermore, palpation is non-quantitative and cannot be used to localize the lesion. Magnetic Resonance-guided Focused Ultrasound (MRgFUS) can also be used to evaluate the properties of biological tissues non-invasively. In this study, an MRgFUS system combines high field (7T) MR and 3 MHz focused ultrasound to provide high resolution MR imaging and a small ultrasonic interrogation region (~0.5 x 0.5 x 2 mm), as compared with current clinical systems. MR-Acoustic Radiation Force Imaging (MR-ARFI) provides a reliable and efficient method for beam localization by detecting micron-scale displacements induced by ultrasound mechanical forces. The first aim of this study is to develop a sequence that can concurrently quantify acoustic radiation force displacements and image the resulting transient shear wave. Our motivation in combining these two measurements is to develop a technique that can rapidly provide both ARFI and shear wave velocity estimation data, making it suitable for use in interventional radiology. Secondly, we validate this sequence in vivo by estimating the displacement before and after high intensity focused ultrasound (HIFU) ablation, and we validate the shear wave velocity in vitro using tissue-mimicking gelatin and tofu phantoms. Such rapid acquisitions are especially useful in interventional radiology applications where minimizing scan time is highly desirable.
Document type :
Journal articles
Complete list of metadata
Contributor : Marianne Leriche <>
Submitted on : Thursday, June 28, 2018 - 4:12:54 PM
Last modification on : Wednesday, October 14, 2020 - 4:16:01 AM

Links full text




Yu Liu, Brett Fite, Lisa Mahakian, Sarah Johnson, Benoît Larrat, et al.. Concurrent Visualization of Acoustic Radiation Force Displacement and Shear Wave Propagation with 7T MRI. PLoS ONE, Public Library of Science, 2015, 10, pp.139667. ⟨10.1371/journal.pone.0139667⟩. ⟨cea-01825835⟩



Record views