Biomimetic diamond MEMS sensors based on odorant-binding proteins: Sensors validation through an autonomous electronic system

M. Possas-Abreu (1) , L. Rousseau (1) , F. Ghassemi (1) , G. Lissorgues (1) , M. Habchi (2) , Emmanuel Scorsone (2) , K. Cal (3) , K. Persaud (3)

1 ESYCOM - Electronique, Systèmes de communication et Microsystèmes
2 LCD-LIST - Laboratoire Capteurs Diamant
3 School of Chemical Engineering and Analytical Sciences [Manchester]

Odorant binding proteins (OBPs) have been considered one of the best candidates for conceiving a biosensor to detect biochemical molecules and for odor sensor applications. In the same way, MEMS sensors for chemical and biological applications proved to be a good option for applications requiring high sensitivity. In this context, micro-cantilever sensor is one of the most promising micromechanical sensor. In this paper a grafting method, compatible with MEMS technology, was used for grafting porcine OBPs on polycrystalline diamond cantilevers. These sensors have been tested, for the first time, in combination with an autonomous dedicated electronic system developed to automatically detect sensors response signals. Electronic detection of binding 2-isobutyl-3-methoxypyrazine (IBMP) to OBP was demonstrated.

Keywords: Biomimetics; Diamond; Bins; Grafting (chemical); Nanocantilevers; MEMS; Odors; Proteins; Sensor arrays; Electronic nose; Polycrystalline diamonds; Signal detection; Sensor Array; Sensor read-out; Diamond micro-cantilever; Index Terms-Odorant Binding Proteins; Odorant-binding proteins; Autonomous electronics; Biochemical molecules; Chemical and biologicals; Micro cantilever sensors; Micro-cantilevers; Micromechanical sensors

Domains: Instrumentation and Detectors [physics.ins-det]; Analytical chemistry; Micro and nanotechnologies/Microelectronics; Electromagnetism; Materials; Biomaterials

M. Possas-Abreu, L. Rousseau, F. Ghassemi, G. Lissorgues, M. Habchi, et al.. Biomimetic diamond MEMS sensors based on odorant-binding proteins: Sensors validation through an autonomous electronic system. 2017 ISOCS/IEEE International Symposium on Olfaction and Electronic Nose (ISOEN), May 2017, Montréal, Canada. pp.7968909, ⟨10.1109/ISOEN.2017.7968909⟩. ⟨cea-01809228⟩