Azo-polysiloxanes as new supports for cell cultures

Nicolae Hurduc (1) , Alina Macovei (2) , Cristina Paius (1) , Alina Raicu (1) , Ioana Moleavin (3) , Norica Branza-Nichita (2) , Matthieu Hamel (3) , Licinio Rocha (3)

1 "Gheorghe Asachi" Technical University of Iaşi - Faculty of Chemical Engineering and Environmental Protection
2 Institute of Biochemistry of the Romanian Academy
3 LCAE (CEA, LIST) - Laboratoire Capteurs et Architectures Electroniques (CEA, LIST)

The paper introduces a new class of materials with azo-polysiloxanic structure bearing the property to generate nano-structured surfaces by laser irradiation. The ability to modulate the optical response of the film, through a modification of the polymer chemical structure, has been investigated. The azo-materials were tested for their ability to support cell adhesion and growth, with very promising results. A future use of these materials as growth support in cell cultures is of great interest, due to an easy, one step-method to generate the surface relief grating and to the possibility to introduce a large range of chemical modifications due to the presence of the chlorobenzyl groups in the polymeric side-chain.

Mots clés: Surface relief gratings; Laser nano-structuration; Azo-polysiloxanes; Cell cultures; laser, instrumentation

Domaines: Biochimie, Biologie Moléculaire; Polymères; Optique / photonique

Nicolae Hurduc, Alina Macovei, Cristina Paius, Alina Raicu, Ioana Moleavin, et al.. Azo-polysiloxanes as new supports for cell cultures. Materials Science and Engineering: C, 2013, 33 (4), pp.2440 - 2445. ⟨10.1016/j.msec.2013.01.012⟩. ⟨cea-01802293⟩