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Standardization of 68Ge / 68Ga using the 4pi beta-gamma coincidence method based on Cherenkov counting

Christophe Bobin 1 Cheick Thiam 1 Jacques Bouchard 1
1 LNHB - Laboratoire National Henri Becquerel
DM2I - Département Métrologie Instrumentation & Information : DRT/LIST/DM2I
Abstract : In the framework of an international BIPM comparison (Bureau International des Poids et Mesures), the activity standardization of 68Ge in a solution of 68Ge/68Ga in equilibrium provided by NIST was carried out at LNHB. This exercise was organized to meet the growing interest in 68Ga as a radiopharmaceutical in nuclear medicine services (e.g. as a surrogate of 18F for PET imaging). Due to the volatility of germanium, the activity standardization of Ge-68 was investigated at LNHB by means of 4 pi beta-gamma coincidence counting based on Cherenkov measurements. This technique was applied to take advantage of the Cherenkov threshold (similar to 260 keV in aqueous solutions) in order to prevent counting from electron-capture events associated with Ge-68 disintegrations. Cherenkov counting was performed using glass and polyethylene vials and the resulting activity concentrations were compared with 4 pi beta-gamma coincidence measurements based on liquid scintillation. The efficiency-extrapolation curve obtained with Cherenkov measurements in glass vials was compared to Monte Carlo simulations based on the Geant4 code.
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Submitted on : Friday, May 25, 2018 - 11:17:47 AM
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Christophe Bobin, Cheick Thiam, Jacques Bouchard. Standardization of 68Ge / 68Ga using the 4pi beta-gamma coincidence method based on Cherenkov counting. Applied Radiation and Isotopes, Elsevier, 2018, 134 (SI), pp.252-256. ⟨10.1016/j.apradiso.2017.06.044⟩. ⟨cea-01799861⟩



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