B. Rosenberg, L. Van-camp, T. Krigas, ;. Rosenberg, L. Van-camp et al., Nature, vol.205, p.385, 1965.

B. Lippert, ;. D. Cisplatin, R. Lebwohl, ;. E. Canetta, C. M. Wong et al., Chemistry and biochemistry of a leading anticancer drug, vol.34, p.633, 1998.

F. R. Hartley, The chemistry of platinum and palladium: with particular reference to complexes of the elements, 1973.

N. Farrell, D. M. Kiley, W. Schmidt, M. P. Hacker-;-b, ). J. Landi et al., The same group has also reported the preparation of transdiammine(chloro)(sulfoxyde)platinum complexes, Inorg. Chim. Acta, vol.29, p.1745, 1990.

S. Shamsuddin, S. Al-baker, Z. H. Siddik, and A. R. Khokhar, Inorg. Chim. Acta, vol.241, p.101, 1996.

A. R. Mukhopadhyay and . Khokhar, J. Coord. Chem, vol.56, p.49, 2003.

A. Pasini, G. Alfonso, C. Manzotti, M. Moret, S. Spinelli et al., Inorg. Chem, vol.33, p.4140, 1994.

A. Pasini, P. Perego, M. Balconi, and M. Lupatini, J. Chem. Soc, issue.4, p.579, 1995.

U. Frey, J. Ranford, and P. Sadler, J. Inorg. Biochem, vol.32, p.181, 1993.

F. Legendre, V. Bas, J. Kozelka, and J. Chottard, Chem. Eur. J, vol.6, 2000.

J. H. Lin, Bone, vol.18, p.75, 1996.

T. Klenner, P. Valenzuela-paz, F. Amelung, H. Münch, H. Zahn et al., Metal Complexes in Cancer Chemotherapy. VCH Weinheim, p.85, 1993.

L. S. Hollis, A. V. Miller, A. R. Amundsen, J. E. Schurig, and E. W. Stern, J. Med. Chem, vol.33, p.105, 1990.

M. Laforgia, L. Cerasino, N. Margiotta, M. A. Capozzi, C. Cardellicchio et al., Eur. J. Inorg. Chem, vol.50, p.3434, 2004.

R. Sasanelli, A. Boccarelli, D. Giordano, M. Laforgia, F. Arnesano et al., J. Med. Chem, vol.50, p.3434, 2007.

C. Mauger, M. Vazeux, A. Albinati, and J. Kozelka, Inorg. Chem. Commun, vol.3, p.704, 2000.

J. Kozelka, M. Hamel, S. Rizzato, M. Lecinq, M. Vazeux et al., J. Biol. Inorg. Chem, vol.12, p.5441, 2007.

, Top. Curr. Chem, vol.229, p.161, 2003.

S. Masson, J. Saint-clair, and M. Saquet, Bull. Soc. Chim. Fr, vol.133, p.951, 1993.

P. Lassaux, M. Hamel, M. Gulea, H. Delbrück, P. S. Mercuri et al.,

K. Frère, M. Hoffmann, C. Galleni, and . Bebrone, J. Med. Chem, vol.53, p.4862, 2010.

C. E. Mckenna, M. T. Higa, N. H. Cheung, and M. Mckenna, Tetrahedron Lett, vol.18, p.155, 1977.

A. Holý, Synthesis, p.381, 1998.

P. S. Pregosin, Coord. Chem. Rev, vol.44, p.247, 1982.

N. Nédélec and F. D. Rochon, Inorg. Chim. Acta, vol.319, p.95, 2001.

S. Gladiali, D. Fabbri, L. Kollàr, C. Claver, N. Ruiz et al., Eur. J. Inorg. Chem, p.113, 1998.

J. Sandström, Yield 61%; MP: 112°C (acetone). 1 H NMR (250 MHz, Dynamic NMR Spectroscopy. Academic, London, p.82, 1982.

. Mhz,

, 8 (d, 4 J CP = 2.5); 134.4 (d, 2 J CP = 9.4); 143.2 (d, 2 J CP = 8.8). MSMS m/z (%): 269 (M+Na; 100), vol.132, p.209

, 015 mmol) in acetone (12 mL) was added dropwise an aqueous solution of sodium metaperiodate (239 mg, 1.1 equiv, 1.117 mmol, in 5 mL H 2 O) at 0°C. After complete addition the flask was conserved in the fridge overnight. The precipitate was then filtered, and the residue was crystallized from acetone / diethyl ether 1:1. Yield: 61%; white solid. 1 H NMR (400 MHz

. Mhz,

, Trans-dichlorido-bis-{2-(diisopropylphosphoryl)phenyl methyl sulfide}platinum, p.9

, To 1.5 mL of an aqueous solution of potassium tetrachloroplatinate (128 mg, 1 equiv, 0.308 mmol) was added

6. Yield and . Mp-=-188°c, 1 H NMR (400 MHz

, CDCl, vol.3

C. Nmr, MHz, issue.101

, Trans-dichlorido-bis-{2-(diisopropylphosphoryl)benzyl methyl sulfide}platinum, p.10

, CDCl, vol.3

, PtS 2 (M+H): calculated 870.1314; found 870, 1301.

, Cis-diammine-chlorido-{2-(diisopropylphosphoryl)phenyl methyl sulfide}platinum (II) nitrate 11

, To a slurry methanolic solution of cisplatin (40 mg, 1 equiv, 0.133 mmol) and the sulfide 1 (38 mg, 1 equiv, 0.133 mmol) was added AgNO 3 (22 mg, 1 equiv, 0.133 mmol) dissolved in boiling MeOH

J. Cp-=, 5 (d, 4 J CP = 2.6), vol.134, p.2925

, Cis-diammino-chlorido-{2-(diisopropylphosphoryl)benzyl methyl sulfide}platinum (II) nitrate 12

, CD 3 OD): ? 1.30 (d, 6H, 3 J HH = 6.0); 1.30 (d, 6H, 3 J HH = 6.4), vol.2

. Mhz, CD 3 OD): ? 14.8. 13 C NMR (101 MHz, CD, vol.3, issue.5

, 4 (d, 2 J CP = 5.8), vol.73

J. Cp-=-14, 3 (d, 4 J CP = 2.8), vol.133

, NO 2 ); 1218; 979. MSMS m/z (%): 567 (MH + ; 40); 550 (M-NH 3 ; 100), vol.508, p.466

, HRMS for C 14 H 29 ClN 2 O 3 PPtS (M + ), p.13

. Yield-73%;-white-solid and . Mp, CD 3 OD): ? 1.29 (d, 6H, 3 J HH = 6.0); 1.30 (d, 6H, 3 J HH = 6.4); 1.34 (d, 3H, 3 J HH = 6.0), 172 -174°C. 1 H NMR (400 MHz, vol.1

P. Nmr, CD 3 OD): ? 23.1 (d, 3 J CP = 5.3); 23.2 (d, 3 J CP = 5.8), 161 MHz, CD 3 OD): ? 15.2. 13 C NMR (101 MHz, vol.23

, Neat) cm -1 : 3165 (? N-H); 2979; 1360 (NO 2 ); 1222; 1139 (? S-O); 983. Analysis for C 14 H 29 ClN

, Cis-diammine-{isopropyl 2-(methylsulfanyl)phenylphosphonato}platinum (II) nitrate 14

, Cis-diamminedichloroplatinum (300 mg, 1 mmol, 1.00 equiv) and silver nitrate (334 mg, 1.99 mmol, vol.1, p.99

, ) 2 was added. The reaction was stirred for 5 hours at 65°C. After filtration, the solution was left in the fridge for crystallization. The obtained solid was filtered off, washed with Et 2 O and dried under vacuum, equiv) were dissolved in distilled water. The solution was stirred during 24 hours at room temperature

, D 2 O): ? 1.22 (d, 3H, 3 J HH = 6.2); 1.30 (d, 3H, 3 J HH = 5.8); 2.54 (s, 3H), p.1902

, Cis-diammine-{isopropyl 2-(methylsulfinyl)phenylphosphonato}platinum (II) nitrate 15

, D 2 O): ? 1.30 (d, 3H, 3 J HH = 6.2); 1.40 (d, 3H, 3 J HH = 6.2); 3.10 (s, 3H), p.2390

, Cis-ethylenediammine-{2-(methylsulfanyl)phenylphosphonato}platinum (II) nitrate 16

. Yield-58%;-white-solid and . Mp, D 2 O): ? 2.39 (s, 3H), decomp.). 1 H NMR (400 MHz, vol.7, pp.204-206

, IR (neat) cm -1 : 3157; 2263; 1368; 1123; 1042. MSMS m/z (%): 459 (MH + -NO 3 ; 100), p.379