Skip to Main content Skip to Navigation
Journal articles

Impaired fasting blood glucose is associated to cognitive impairment and cerebral atrophy in middle-aged non-human primates

Abstract : Age-associated cognitive impairment is a major health and social issue because of increasing aged population. Cognitive decline is not homogeneous in humans and the determinants leading to differences between subjects are not fully understood. In middle-aged healthy humans, fasting blood glucose levels in the upper normal range are associated with memory impairment and cerebral atrophy. Due to a close evolutional similarity to Man, non-human primates may be useful to investigate the relationships between glucose homeostasis, cognitive deficits and structural brain alterations. In the grey mouse lemur, $Microcebus\ murinus$, spatial memory deficits have been associated with age and cerebral atrophy but the origin of these alterations have not been clearly identified. Herein, we showed that, on 28 female grey mouse lemurs (age range 2.4-6.1 years-old), age correlated with impaired fasting blood glucose (r$_s$=0.37) but not with impaired glucose tolerance or insulin resistance. In middle-aged animals (4.1-6.1 years-old), fasting blood glucose was inversely and closely linked with spatial memory performance (r$_s$=0.56) and hippocampus (r$_s$=-0.62) or septum (r$_s$=-0.55) volumes. These findings corroborate observations in humans and further support the grey mouse lemur as a natural model to unravel mechanisms which link impaired glucose homeostasis, brain atrophy and cognitive processes.
Document type :
Journal articles
Complete list of metadatas

https://hal-cea.archives-ouvertes.fr/cea-01752020
Contributor : Florence Mousson <>
Submitted on : Thursday, March 29, 2018 - 1:31:05 PM
Last modification on : Saturday, September 19, 2020 - 3:34:34 AM

Links full text

Identifiers

Citation

Fathia Djelti, Marc Dhenain, Jérémy Terrien, Jean-Luc Picq, Isabelle Hardy, et al.. Impaired fasting blood glucose is associated to cognitive impairment and cerebral atrophy in middle-aged non-human primates. Aging, Superintendent of Documents, U.S. Government Printing Office, 2016, 9, pp.173 - 186. ⟨10.18632/aging.101148⟩. ⟨cea-01752020⟩

Share

Metrics

Record views

460