Confinement of a tris-aqua Gd(III) complex in silica nanoparticles leads to high stability and high relaxivity and supresses anion binding

Maria Moula Karimdjy; Gaylord Tallec; Pascal H. Fries; Daniel Imbert; Marinella Mazzanti

doi:10.1039/c5cc01352f

Journal articles

Confinement of a tris-aqua Gd(III) complex in silica nanoparticles leads to high stability and high relaxivity and supresses anion binding

Maria Moula Karimdjy ¹ Gaylord Tallec ¹ Pascal H. Fries ¹ Daniel Imbert ¹ Marinella Mazzanti ²

1 RICC - Reconnaissance Ionique et Chimie de Coordination

SYMMES - SYstèmes Moléculaires et nanoMatériaux pour l’Energie et la Santé : DRF/INAC/SYMMES

2 GGRC-ISIC-EPFL

Abstract : The water soluble tris-aqua complex [Gd(dhqN-SO3)(H2O)(3)](3-) based on a hexadentate hydroxyquinoline ligand shows high thermodynamic stability and high relaxivity (12.54 mM(-1) s(-1) at 1.2 T). Its non-covalent confinement in 25 nm silica nanoparticles prevents transmetallation and endogenous anion binding and leads to higher relaxivity over a wide range of magnetic fields.

Keywords : MRI Contrast Agents Gadolinium Complex

Document type :

Journal articles

Domain :

Physics [physics]

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https://hal-cea.archives-ouvertes.fr/cea-01734604
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Submitted on : Wednesday, March 14, 2018 - 6:03:58 PM
Last modification on : Wednesday, December 15, 2021 - 10:01:04 AM

Confinement of a tris-aqua Gd(III) complex in silica nanoparticles leads to high stability and high relaxivity and supresses anion binding

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Confinement of a tris-aqua Gd(III) complex in silica nanoparticles leads to high stability and high relaxivity and supresses anion binding

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