Confinement of a tris-aqua Gd(III) complex in silica nanoparticles leads to high stability and high relaxivity and supresses anion binding

Maria Moula Karimdjy (1) , Gaylord Tallec (1) , Pascal H. Fries (1) , Daniel Imbert (1) , Marinella Mazzanti (2)

1 RICC - Reconnaissance Ionique et Chimie de Coordination
2 GGRC-ISIC-EPFL

The water soluble tris-aqua complex [Gd(dhqN-SO3)(H2O)(3)](3-) based on a hexadentate hydroxyquinoline ligand shows high thermodynamic stability and high relaxivity (12.54 mM(-1) s(-1) at 1.2 T). Its non-covalent confinement in 25 nm silica nanoparticles prevents transmetallation and endogenous anion binding and leads to higher relaxivity over a wide range of magnetic fields.

Keywords: MRI Contrast Agents; Gadolinium Complex

Domains: Physics [physics]

Maria Moula Karimdjy, Gaylord Tallec, Pascal H. Fries, Daniel Imbert, Marinella Mazzanti. Confinement of a tris-aqua Gd(III) complex in silica nanoparticles leads to high stability and high relaxivity and supresses anion binding. Chemical Communications, 2015, 51 (31), pp.6836-6838. ⟨10.1039/c5cc01352f⟩. ⟨cea-01734604⟩