Confinement of a tris-aqua Gd(III) complex in silica nanoparticles leads to high stability and high relaxivity and supresses anion binding

Maria Moula Karimdjy 1 Gaylord Tallec 1 Pascal H. Fries 1 Daniel Imbert 1 Marinella Mazzanti 2
1 RICC - Reconnaissance Ionique et Chimie de Coordination
SYMMES - SYstèmes Moléculaires et nanoMatériaux pour l’Energie et la Santé : DRF/INAC/SYMMES
Abstract : The water soluble tris-aqua complex [Gd(dhqN-SO3)(H2O)(3)](3-) based on a hexadentate hydroxyquinoline ligand shows high thermodynamic stability and high relaxivity (12.54 mM(-1) s(-1) at 1.2 T). Its non-covalent confinement in 25 nm silica nanoparticles prevents transmetallation and endogenous anion binding and leads to higher relaxivity over a wide range of magnetic fields.
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Submitted on : Wednesday, March 14, 2018 - 6:03:58 PM
Last modification on : Thursday, October 17, 2019 - 4:42:01 PM

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Maria Moula Karimdjy, Gaylord Tallec, Pascal H. Fries, Daniel Imbert, Marinella Mazzanti. Confinement of a tris-aqua Gd(III) complex in silica nanoparticles leads to high stability and high relaxivity and supresses anion binding. Chemical Communications, Royal Society of Chemistry, 2015, 51 (31), pp.6836-6838. ⟨10.1039/c5cc01352f⟩. ⟨cea-01734604⟩

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