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Journal articles
A practical synthesis of valuable strained 8-membered ring derivatives for click chemistry
Abstract : A convenient and cost-effective synthetic access to cyclooctyne and trans-cyclooctene derivatives is described. A cyclopropanation step using copper powder in lieu of Rh₂(OAc)₄ as catalyst and a symmetric diazomalonate enabled to drastically reduce the overall cost of the synthesis. Further derivatizations allowed to characterize, for the first time, the structure of a BCN analogue by X-ray crystallography and obtain a library of derivatives potentially useful for applications in metal free click chemistry.
https://hal-cea.archives-ouvertes.fr/cea-01730661
Contributor : Serge Palacin Connect in order to contact the contributor
Submitted on : Tuesday, March 13, 2018 - 2:41:24 PM
Last modification on : Thursday, July 8, 2021 - 3:51:17 AM
Contributor : Serge Palacin Connect in order to contact the contributor
Submitted on : Tuesday, March 13, 2018 - 2:41:24 PM
Last modification on : Thursday, July 8, 2021 - 3:51:17 AM