Synthesis of a multi-branched porphyrin-oligonucleotide scaffold for the construction of DNA-Based nano-architecture

Grégory Chatelain (1) , Guillaume Clavé (1) , Didier Gasparutto (2) , Eric Le Cam (3) , Olivier Piétrement (3) , Stéphane Campidelli (1)

1 LICSEN UMR 3685 - Laboratoire Innovation en Chimie des Surfaces et NanoSciences
2 LAN - Laboratoire Lésions des Acides Nucléiques
3 UMR8126 - Signalisation, noyaux et innovations en cancérologie

Porphytin-oligonudeotide hybrids containing one to four DNA strands (P1-P4) have been synthesised and fully characterised. The hybrid P4, which inserts one porphyrin and four DNA fragments, was combined with gold nanoparticles and images by electron microscopy.

Domaines: Matériaux

Grégory Chatelain, Guillaume Clavé, Didier Gasparutto, Eric Le Cam, Olivier Piétrement, et al.. Synthesis of a multi-branched porphyrin-oligonucleotide scaffold for the construction of DNA-Based nano-architecture. Collection of Czechoslovak Chemical Communications, 2015, ⟨10.1135/css201414197⟩. ⟨cea-01709773⟩