A Straightforward Access to Cyclotriveratrylene Analogues with C1-Symmetry: Toward the Synthesis of Monofunctionalizable Cryptophanes

Gaëlle Milanole (1) , Grégory Pieters (1) , Bo Gao (1) , Emilie Mari (2) , Bernard Rousseau (1) , Patrick Berthault (2)

1 SCBM - Service de Chimie Bio-Organique et de Marquage
2 LSDRM - Laboratoire Structure et Dynamique par Résonance Magnétique (LCF)

A straightforward and practical access to various C1-symmetric cyclotriveratrylene derivatives from a monohalogenated cyclotriphenolene is described. This unique scaffold can also be used as a precursor for the rapid construction of monofunctionalizable cryptophane-based biosensors for hyperpolarized $^{129}$Xe MRI.

Domains: Chemical Sciences; Material chemistry

Gaëlle Milanole, Grégory Pieters, Bo Gao, Emilie Mari, Bernard Rousseau, et al.. A Straightforward Access to Cyclotriveratrylene Analogues with C1-Symmetry: Toward the Synthesis of Monofunctionalizable Cryptophanes. European Journal of Organic Chemistry, 2017, 47, pp.7091-7100. ⟨10.1002/ejoc.201701353⟩. ⟨cea-01622050⟩