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Journal articles
Guanine glycation repair by DJ-1/Park7 and its bacterial homologs
Gilbert Richarme
1, 2, *
Cailing Liu
3
Mouadh Mihoub
1
Jad Abdallah
4, 1
Leger Thibaut
1
Nicolas Joly
1, 5
Jean-Claude Liebart
1
Ula Jurkunas
3
Marc Nadal
1
Philippe Bouloc
6, 7
Julien Dairou
2
Aazdine Lamouri
8
*
Corresponding author
Gilbert Richarme 1, 2
Correspondent author
Cailing Liu 3
Author
Mouadh Mihoub 1
Author
Jad Abdallah 4, 1
Author
Leger Thibaut 1
Author IdHAL : thibaut-leger ORCID : https://orcid.org/0000-0002-6304-3433
Nicolas Joly 1, 5
Author IdHAL : nico-joly ORCID : https://orcid.org/0000-0003-2731-3827
Jean-Claude Liebart 1
Author
Ula V. Jurkunas 3
Author
1
IJM (UMR_7592) - Institut Jacques Monod (Université Paris Diderot, Bât. Buffon, 15 rue Hélène Brion, 75205 Paris cédex 13 - France)
- UPD7 - Université Paris Diderot - Paris 7 : UMR_7592 (5 rue Thomas-Mann - 75205 Paris cedex 13 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR_7592 (France)
2
LCBPT - UMR 8601 - Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques (45 Rue des Saints-Pères
75270 PARIS CEDEX 06 - France)
- UPD5 - Université Paris Descartes - Paris 5 : UMR 8601 (12, rue de l'École de Médecine - 75270 Paris cedex 06 - France)
- INC - Institut de Chimie du CNRS (3 Rue Michel-Ange 75 016 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR 8601 (France)
3
Massachusetts Eye and Ear Infirmary (affiliated with Harvard Medical School) (Boston, Massachusetts. - United States)
- Massachusetts Eye and Ear Infirmary (France)
4
LAU - Lebanese American University (Lebanon)
5
Max Planck Institute for the Science of Light (Staudtstraße 2, 91058 Erlangen - Germany)
- Max-Planck-Gesellschaft (Jägerstrasse, 10-11, D-10117 Berlin - Germany)
6
I2BC - Institut de Biologie Intégrative de la Cellule (Bâtiment 21, 1 avenue de la Terrasse, 91198 Gif/Yvette cedex - France)
- CEA - Commissariat à l'énergie atomique et aux énergies alternatives : DRF/I2BC (Centre de Saclay Centre de Grenoble Centre de Cadarache etc - France)
- Université Paris-Saclay (Bâtiment Bréguet, 3 Rue Joliot Curie 2e ét, 91190 Gif-sur-Yvette - France)
- CNRS - Centre National de la Recherche Scientifique : UMR 9198 (France)
7
SRRB - Signalisation et Réseaux de Régulations Bactériens (I2BC, Bâtiment 21, 1 avenue de la Terrasse, 91198 Gif/Yvette cedex - France)
- DBG - Département Biologie des Génomes (I2BC, Bâtiment 21, 1 avenue de la Terrasse, 91198 Gif/Yvette cedex - France)
- I2BC - Institut de Biologie Intégrative de la Cellule (Bâtiment 21, 1 avenue de la Terrasse, 91198 Gif/Yvette cedex - France)
- CEA - Commissariat à l'énergie atomique et aux énergies alternatives : DRF/I2BC (Centre de Saclay Centre de Grenoble Centre de Cadarache etc - France)
- Université Paris-Saclay (Bâtiment Bréguet, 3 Rue Joliot Curie 2e ét, 91190 Gif-sur-Yvette - France)
- CNRS - Centre National de la Recherche Scientifique : UMR 9198 (France)
- I2BC - Institut de Biologie Intégrative de la Cellule (Bâtiment 21, 1 avenue de la Terrasse, 91198 Gif/Yvette cedex - France)
8
ITODYS (UMR_7086) - Interfaces, Traitements, Organisation et Dynamique des Systèmes (Université Paris Diderot, Bâtiment Lavoisier, 15 rue Jean de Baïf, case postale 7090, 75205 Paris Cedex 13 - France)
- UPD7 - Université Paris Diderot - Paris 7 : UMR_7086 (5 rue Thomas-Mann - 75205 Paris cedex 13 - France)
- INC - Institut de Chimie du CNRS (3 Rue Michel-Ange 75 016 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR_7086 (France)
Abstract : DNA damage induced by reactive carbonyls (mainly methylglyoxal and glyoxal), called DNA glycation, is quantitatively as important as oxidative damage. DNA glycation is associated with increased mutation frequency, DNA strand breaks, and cytotoxicity. However, in contrast to guanine oxidation repair, how glycated DNA is repaired remains undetermined. Here, we found that the parkinsonism-associated protein DJ-1 and its bacterial homologs Hsp31, YhbO, and YajL could repair methylglyoxal- and glyoxal-glycated nucleotides and nucleic acids. DJ-1–depleted cells displayed increased levels of glycated DNA, DNA strand breaks, and phosphorylated p53. Deglycase-deficient bacterial mutants displayed increased levels of glycated DNA and RNA and exhibited strong mutator phenotypes. Thus, DJ-1 and its prokaryotic homologs constitute a major nucleotide repair system that we name guanine glycation repair.
Document type :
Journal articles
Domain :
Complete list of metadata
https://hal-cea.archives-ouvertes.fr/cea-01588317
Contributor : Quentin Jaillard Connect in order to contact the contributor
Submitted on : Friday, September 15, 2017 - 2:46:04 PM
Last modification on : Friday, January 7, 2022 - 3:53:41 AM
Contributor : Quentin Jaillard Connect in order to contact the contributor
Submitted on : Friday, September 15, 2017 - 2:46:04 PM
Last modification on : Friday, January 7, 2022 - 3:53:41 AM
Identifiers
- HAL Id : cea-01588317, version 1
- DOI : 10.1126/science.aag1095
- PUBMED : 28596309
Collections
CEA | CNRS | UNIV-PARIS7 | UNIV-PARIS5 | USPC | CEA-UPSAY | I2BC | CEA-DRF | JOLIOT | UNIV-PARIS | UP-SCIENCES | GS-ENGINEERING | GS-BIOSPHERA | IJM | INSTITUT-SCIENCES-LUMIERE | GS-HEALTH-DRUG-SCIENCES | INC-CNRS
Citation
Gilbert Richarme, Cailing Liu, Mouadh Mihoub, Jad Abdallah, Leger Thibaut, et al.. Guanine glycation repair by DJ-1/Park7 and its bacterial homologs. Science, American Association for the Advancement of Science, 2017, 357 (6347), pp.208-211. ⟨10.1126/science.aag1095⟩. ⟨cea-01588317⟩
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