Ecocatalyzed Suzuki cross coupling of heteroaryl compounds

Guillaume Clavé (1) , Franck Pelissier (1) , Stéphane Campidelli (2) , Claude Grison (1)

1 ChimEco - Bio-inspired Chemistry and Ecological Innovations
2 LICSEN - Laboratoire Innovation en Chimie des Surfaces et NanoSciences

A bio-based EcoPd was developed for the Suzuki cross coupling of heteroaryl compounds. Based on the ability of $Eichhornia\ crassipes$ to bioconcentrate Pd in its roots, we addressed the transformation of plant-derived Pd metals to green catalysts. The methodology is based on eco-friendly procedures. It allowed the preparation of a wide range of heterocyclic biaryl and heterocyclic–heterocyclic biaryl compounds, with a low Pd catalyst loading. EcoPd was found to have the ideal microstructure to promote complex Suzuki reactions without ligands or additives. For the first time, post-reaction solution was treated by rhizofiltration. The resulting EcoPd has been reused with the same performance. This work has established the ecocatalysis concept as a powerful strategy for Pd sustainability, with the development of homogeneous catalysts that are easily recycled and reused.

Domains: Chemical Sciences; Material chemistry

Guillaume Clavé, Franck Pelissier, Stéphane Campidelli, Claude Grison. Ecocatalyzed Suzuki cross coupling of heteroaryl compounds. Green Chemistry, 2017, International Symposium on Green Chemistry 2017, 19, pp.4093-4103. ⟨10.1039/c7gc01672g⟩. ⟨cea-01577263⟩