Xe NMR-based sensors: biological applications and recent methods

E Mari 1 P Berthault 1
1 LSDRM - Laboratoire Structure et Dynamique par Résonance Magnétique (LCF)
NIMBE UMR 3685 - Nanosciences et Innovation pour les Matériaux, la Biomédecine et l'Energie (ex SIS2M)
Abstract : Xenon is a first-rate sensor of biological events, due to its large polarizable electron cloud inducing significant modification of NMR parameters through slight changes in its local environment. The use of xenon as a sensor is of increasing interest for sensitive magnetic resonance imaging, since its signal can be enhanced by several orders of magnitude, mainly by spin-exchange optical pumping. Furthermore xenon can be vectorized toward targets of interest by using functionalized host systems, enabling their detection at subnanomolar concentrations. Associated with a new generation of detection methods this gives rise to a powerful molecular imaging approach, where xenon can be delivered on purpose several times after introduction of the functionalized host system.
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Analyst, Royal Society of Chemistry, 2017, 142, pp.3298-3308. 〈http://dx.doi.org/10.1039/C7AN01088E〉. 〈10.1039/C7AN01088E〉
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E Mari, P Berthault. Xe NMR-based sensors: biological applications and recent methods. Analyst, Royal Society of Chemistry, 2017, 142, pp.3298-3308. 〈http://dx.doi.org/10.1039/C7AN01088E〉. 〈10.1039/C7AN01088E〉. 〈cea-01573931〉

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