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Journal Articles Analyst Year : 2017

Xe NMR-based sensors: biological applications and recent methods

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Abstract

Xenon is a first-rate sensor of biological events, due to its large polarizable electron cloud inducing significant modification of NMR parameters through slight changes in its local environment. The use of xenon as a sensor is of increasing interest for sensitive magnetic resonance imaging, since its signal can be enhanced by several orders of magnitude, mainly by spin-exchange optical pumping. Furthermore xenon can be vectorized toward targets of interest by using functionalized host systems, enabling their detection at subnanomolar concentrations. Associated with a new generation of detection methods this gives rise to a powerful molecular imaging approach, where xenon can be delivered on purpose several times after introduction of the functionalized host system.
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cea-01573931 , version 1 (11-08-2017)

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Attribution - CC BY 4.0

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E Mari, P Berthault. Xe NMR-based sensors: biological applications and recent methods. Analyst, 2017, 142, pp.3298-3308. ⟨10.1039/C7AN01088E⟩. ⟨cea-01573931⟩
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