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Self-assembly of porphyrin–DNA hybrids into large flat nanostructures

Abstract : The main aim of nanotechnology is to create functional systems by controlling the matter at the nano-meter level. In this context DNA is a versatile building block for the fabrication of micrometer-scale objects with a subnanometer-scale resolution. Over the last 15 years, DNA nanotechnology has considerably developed with the invention of DNA origami, double crossover structures and molecule/ oligonucleotide hybrids. Our interest is focused on the combination of short complementary DNA sequences with organic molecules with a view to create large self-assembled nanostructures. Here we report on the synthesis of porphyrin derivatives bearing up to four 21-mer oligonucleotides and we demonstrate that the combination of the molecular hybrids containing complementary DNA strands leads to the formation of large nanostructures with micrometer-scale size.
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Contributor : Serge Palacin <>
Submitted on : Wednesday, August 2, 2017 - 2:19:33 PM
Last modification on : Friday, July 10, 2020 - 7:58:54 AM



Grégory Chatelain, Guillaume Clavé, C. Saint-Pierre, D Gasparutto, S Campidelli. Self-assembly of porphyrin–DNA hybrids into large flat nanostructures. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2017, 15, pp.6257 - 6263. ⟨10.1039/c7ob01267e⟩. ⟨cea-01571405⟩



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