 |
Journal articles
Ultrafast Fluorescence Dynamics in Flurbiprofen–Amino Acid Dyads and in the Supramolecular Drug/Protein Complex
Abstract : The interaction dynamics between the drug flurbiprofen (FBP) and human serum albumin (HSA) has been investigated by time-resolved fluorescence spectroscopy, combining femtosecond fluorescence upconversion and picosecond time-correlated single photon counting. In order to obtain additional information on the drug/ protein interaction, several covalently linked model dyads, composed of FBP and tryptophan or tyrosine, were also studied. For all systems, the main feature was a remarkable dynamic FBP fluorescence quenching, more prominent in the dyads than in the protein complex. All systems also displayed a clear stereoselectivity depending on the (S)- or (R)-form of FBP, that was strongly influenced by the conformational arrangement of the investigated chromophores.
https://hal-cea.archives-ouvertes.fr/cea-01507101
Contributor : Caroline Lebe Connect in order to contact the contributor
Submitted on : Wednesday, April 12, 2017 - 3:21:00 PM
Last modification on : Friday, January 7, 2022 - 3:52:08 AM
Contributor : Caroline Lebe Connect in order to contact the contributor
Submitted on : Wednesday, April 12, 2017 - 3:21:00 PM
Last modification on : Friday, January 7, 2022 - 3:52:08 AM