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Ultrafast Fluorescence Dynamics in Flurbiprofen–Amino Acid Dyads and in the Supramolecular Drug/Protein Complex

Abstract : The interaction dynamics between the drug flurbiprofen (FBP) and human serum albumin (HSA) has been investigated by time-resolved fluorescence spectroscopy, combining femtosecond fluorescence upconversion and picosecond time-correlated single photon counting. In order to obtain additional information on the drug/ protein interaction, several covalently linked model dyads, composed of FBP and tryptophan or tyrosine, were also studied. For all systems, the main feature was a remarkable dynamic FBP fluorescence quenching, more prominent in the dyads than in the protein complex. All systems also displayed a clear stereoselectivity depending on the (S)- or (R)-form of FBP, that was strongly influenced by the conformational arrangement of the investigated chromophores.
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https://hal-cea.archives-ouvertes.fr/cea-01507101
Contributor : Caroline Lebe <>
Submitted on : Wednesday, April 12, 2017 - 3:21:00 PM
Last modification on : Monday, February 10, 2020 - 6:14:03 PM

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I. Vaya-Perez, M.C. Jimenez, M. Miranda, A. Chatterjee, T. Gustavsson. Ultrafast Fluorescence Dynamics in Flurbiprofen–Amino Acid Dyads and in the Supramolecular Drug/Protein Complex . CHIMIA, Schweizerische Chemische Gesellschaft, 2017, 71 (1), pp.18-25(8). ⟨10.2533/chimia.2017.18⟩. ⟨cea-01507101⟩

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