Skip to Main content Skip to Navigation
Journal articles

Enhancing NMR of non-relaxing species using a controlled flow motion and a miniaturized circuit

Guillaume Carret 1 Thomas Berthelot 2 Patrick Berthault 1
1 LSDRM - Laboratoire Structure et Dynamique par Résonance Magnétique (LCF)
NIMBE UMR 3685 - Nanosciences et Innovation pour les Matériaux, la Biomédecine et l'Energie (ex SIS2M)
2 LICSEN - Laboratoire Innovation en Chimie des Surfaces et NanoSciences
NIMBE UMR 3685 - Nanosciences et Innovation pour les Matériaux, la Biomédecine et l'Energie (ex SIS2M)
Abstract : In this Article we show that circulation of the sample in a closed-loop circuit combined to micro sized detection can lead to a significant signal NMR enhancement. We present an optimized NMR device based on a mini bubble-pump associated to fluidics and microdetection that can be installed on a commercial NMR spectrometer. In addition to a significant signal enhancement for slowly relaxing nuclei, we show that it enables more precise and frequent monitoring of chemical reactions. An additional modification leads to a stopped-flow system very efficient for instance for 2D NMR experiments with long mixing times.
Document type :
Journal articles
Complete list of metadatas

Cited literature [17 references]  Display  Hide  Download

https://hal-cea.archives-ouvertes.fr/cea-01449824
Contributor : Serge Palacin <>
Submitted on : Monday, January 30, 2017 - 5:19:03 PM
Last modification on : Monday, February 10, 2020 - 6:13:58 PM

File

Carret_AnalChem2017_VO.pdf
Files produced by the author(s)

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Citation

Guillaume Carret, Thomas Berthelot, Patrick Berthault. Enhancing NMR of non-relaxing species using a controlled flow motion and a miniaturized circuit. Analytical Chemistry, American Chemical Society, 2017, 89, pp.2995-3000. ⟨10.1021/acs.analchem.6b04488⟩. ⟨cea-01449824⟩

Share

Metrics

Record views

226

Files downloads

281