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Journal Articles Analytical Chemistry Year : 2017

Enhancing NMR of non-relaxing species using a controlled flow motion and a miniaturized circuit

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Abstract

In this Article we show that circulation of the sample in a closed-loop circuit combined to micro sized detection can lead to a significant signal NMR enhancement. We present an optimized NMR device based on a mini bubble-pump associated to fluidics and microdetection that can be installed on a commercial NMR spectrometer. In addition to a significant signal enhancement for slowly relaxing nuclei, we show that it enables more precise and frequent monitoring of chemical reactions. An additional modification leads to a stopped-flow system very efficient for instance for 2D NMR experiments with long mixing times.
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Dates and versions

cea-01449824 , version 1 (30-01-2017)

Licence

Attribution - CC BY 4.0

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Guillaume Carret, Thomas Berthelot, Patrick Berthault. Enhancing NMR of non-relaxing species using a controlled flow motion and a miniaturized circuit. Analytical Chemistry, 2017, 89, pp.2995-3000. ⟨10.1021/acs.analchem.6b04488⟩. ⟨cea-01449824⟩
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