Enhancing NMR of non-relaxing species using a controlled flow motion and a miniaturized circuit

Guillaume Carret (1) , Thomas Berthelot (2) , Patrick Berthault (1)

1 LSDRM - Laboratoire Structure et Dynamique par Résonance Magnétique (LCF)
2 LICSEN - Laboratoire Innovation en Chimie des Surfaces et NanoSciences

In this Article we show that circulation of the sample in a closed-loop circuit combined to micro sized detection can lead to a significant signal NMR enhancement. We present an optimized NMR device based on a mini bubble-pump associated to fluidics and microdetection that can be installed on a commercial NMR spectrometer. In addition to a significant signal enhancement for slowly relaxing nuclei, we show that it enables more precise and frequent monitoring of chemical reactions. An additional modification leads to a stopped-flow system very efficient for instance for 2D NMR experiments with long mixing times.

Domains: Material chemistry

Guillaume Carret, Thomas Berthelot, Patrick Berthault. Enhancing NMR of non-relaxing species using a controlled flow motion and a miniaturized circuit. Analytical Chemistry, 2017, 89, pp.2995-3000. ⟨10.1021/acs.analchem.6b04488⟩. ⟨cea-01449824⟩