Enhancing NMR of non-relaxing species using a controlled flow motion and a miniaturized circuit

Guillaume Carret 1 Thomas Berthelot 2 Patrick Berthault 1
1 LSDRM - Laboratoire Structure et Dynamique par Résonance Magnétique (LCF)
NIMBE UMR 3685 - Nanosciences et Innovation pour les Matériaux, la Biomédecine et l'Energie (ex SIS2M)
2 LICSEN - Laboratoire Innovation en Chimie des Surfaces et NanoSciences
NIMBE UMR 3685 - Nanosciences et Innovation pour les Matériaux, la Biomédecine et l'Energie (ex SIS2M)
Abstract : In this Article we show that circulation of the sample in a closed-loop circuit combined to micro sized detection can lead to a significant signal NMR enhancement. We present an optimized NMR device based on a mini bubble-pump associated to fluidics and microdetection that can be installed on a commercial NMR spectrometer. In addition to a significant signal enhancement for slowly relaxing nuclei, we show that it enables more precise and frequent monitoring of chemical reactions. An additional modification leads to a stopped-flow system very efficient for instance for 2D NMR experiments with long mixing times.
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Guillaume Carret, Thomas Berthelot, Patrick Berthault. Enhancing NMR of non-relaxing species using a controlled flow motion and a miniaturized circuit. Analytical Chemistry, American Chemical Society, 2017, 89, pp.2995-3000. ⟨http://pubs.acs.org/doi/abs/10.1021/acs.analchem.6b04488⟩. ⟨10.1021/acs.analchem.6b04488⟩. ⟨cea-01449824⟩

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