UV-Induced Adenine Radicals Induced in DNA A-Tracts: Spectral and Dynamical Characterization

A. Banyasz; T.-M. Ketola; A. Muñoz-Losa; S. Rishi; A. Adhikary; M. D. Sevilla; L. Martinez-Fernandez; R. Improta; D. Markovitsi

UV-Induced Adenine Radicals Induced in DNA A-Tracts: Spectral and Dynamical Characterization

A. Banyasz ^{1, 2} T.-M. Ketola ^{1, 2} A. Muñoz-Losa ^{2, 1} S. Rishi ³ A. Adhikary ³ M. D. Sevilla ³ L. Martinez-Fernandez ⁴ R. Improta ⁴ D. Markovitsi ^{2, 1}

1 DICO - Biomolécules Excitées

IRAMIS - Institut Rayonnement Matière de Saclay, LIDyl - Laboratoire Interactions, Dynamique et Lasers (ex SPAM)

2 LIDyl - Laboratoire Interactions, Dynamique et Lasers (ex SPAM)

3 Department of Chemistry

4 CNR – Istituto di Biostrutture e Bioimmagini

Abstract : Adenyl radicals generated in DNA single and double strands, (dA)20 and (dA)20·(dT)20, by one- and two-photon ionization by 266 nm laser pulses decay at 600 nm with half-times of 1.0 ± 0.1 and 4 ± 1 ms, respectively. Though ionization initially forms the cation radical, the radicals detected for (dA)20 are quantitatively identified as N6-deprotonated adenyl radicals by their absorption spectrum, which is computed quantum mechanically employing TD-DFT. Theoretical calculations show that deprotonation of the cation radical induces only weak spectral changes, in line with the spectra of the adenyl radical cation and the deprotonated radical trapped in low temperature glasses.

Document type :

Journal articles

Domain :

Chemical Sciences / Theoretical and/or physical chemistry

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https://hal-cea.archives-ouvertes.fr/cea-01426170
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Submitted on : Wednesday, January 4, 2017 - 11:58:57 AM
Last modification on : Wednesday, August 7, 2019 - 2:26:06 PM

UV-Induced Adenine Radicals Induced in DNA A-Tracts: Spectral and Dynamical Characterization

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UV-Induced Adenine Radicals Induced in DNA A-Tracts: Spectral and Dynamical Characterization

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