UV-Induced Adenine Radicals Induced in DNA A-Tracts: Spectral and Dynamical Characterization

A. Banyasz 1, 2 T.-M. Ketola 1, 2 A. Muñoz-Losa 2, 1 S. Rishi 3 A. Adhikary 3 M. D. Sevilla 3 L. Martinez-Fernandez 4 R. Improta 4 D. Markovitsi 2, 1
1 DICO - Biomolécules Excitées
IRAMIS - Institut Rayonnement Matière de Saclay, LIDyl - Laboratoire Interactions, Dynamique et Lasers (ex SPAM)
2 LIDyl - Laboratoire Interactions, Dynamique et Lasers (ex SPAM)
3 Department of Chemistry
4 CNR – Istituto di Biostrutture e Bioimmagini
Abstract : Adenyl radicals generated in DNA single and double strands, (dA)20 and (dA)20·(dT)20, by one- and two-photon ionization by 266 nm laser pulses decay at 600 nm with half-times of 1.0 ± 0.1 and 4 ± 1 ms, respectively. Though ionization initially forms the cation radical, the radicals detected for (dA)20 are quantitatively identified as N6-deprotonated adenyl radicals by their absorption spectrum, which is computed quantum mechanically employing TD-DFT. Theoretical calculations show that deprotonation of the cation radical induces only weak spectral changes, in line with the spectra of the adenyl radical cation and the deprotonated radical trapped in low temperature glasses.
Type de document :
Article dans une revue
Journal of Physical Chemistry Letters, American Chemical Society, 2016, 7 (19), pp.3949-3953. 〈10.1021/acs.jpclett.6b01831〉
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https://hal-cea.archives-ouvertes.fr/cea-01426170
Contributeur : Caroline Lebe <>
Soumis le : mercredi 4 janvier 2017 - 11:58:57
Dernière modification le : jeudi 15 mars 2018 - 15:04:27

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CEA | DSM-IRAMIS | IRAMIS-LIDYL | UNIV-PARIS-SACLAY | CEA-DRF | CEA-UPSAY

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A. Banyasz, T.-M. Ketola, A. Muñoz-Losa, S. Rishi, A. Adhikary, et al.. UV-Induced Adenine Radicals Induced in DNA A-Tracts: Spectral and Dynamical Characterization. Journal of Physical Chemistry Letters, American Chemical Society, 2016, 7 (19), pp.3949-3953. 〈10.1021/acs.jpclett.6b01831〉. 〈cea-01426170〉

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